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Herpesvirus-associated central and peripheral nervous system involvement: two clinical cases

https://doi.org/10.14412/2074-2711-2015-2-28-34

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Abstract

Herpesviruses can directly affect the structure of the nervous system, resulting in encephalitis, and also induce immune-mediated disorders of the peripheral nervous system as sensory-predominant chronic inflammatory demyelinating polyneuropathy (CIDP). Patients with immunodeficiency may simultaneously develop two pathological processes, determining the severity of the condition. Parainfectious limbic encephalitis (PILE) associated with viruses from the family Herpes viridae is a form of chronic herpes encephalitis, which is characterized by dysfunction of the limbic system and by a long-term course with exacerbations. CIDP is a dysimmune disease leasing to peripheral nervous system involvement, which belongs to a class of myelinopathies. The paper describes two clinical cases of a concurrence of chronic PILE and CIDP in middle-aged men who have symptomatic status epilepticus and iatrogenic complications. It characterizes difficulties in diagnosis and the clinical features of chronic herpes infection involving the central and peripheral nervous systems. The given clinical cases suggest that not only neurologists
and epileptologists, but also resuscitation specialists and ngiosurgeons should be particularly alert to the pathology in question.

About the Authors

T. E. Popova
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia 1, Partisan Zheleznyak St., Krasnoyarsk 660022
Russian Federation


N. A. Shnayder
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia 1, Partisan Zheleznyak St., Krasnoyarsk 660022 Clinical Hospital Fifty-One, Federal Biomedical Agency of the Russian Federation, Zheleznogorsk, Russia 5, Kirov St., Zheleznogorsk 662971
Russian Federation


M. M. Petrova
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia 1, Partisan Zheleznyak St., Krasnoyarsk 660022
Russian Federation


T. Ya. Nikolaeva
M.K. Amosov North-Eastern Federal University, Ministry of Education of Russia, Yakutsk, Russia 27, Oiunsky St., Yakutsk 677000
Russian Federation


E. A. Kantimirova
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia 1, Partisan Zheleznyak St., Krasnoyarsk 660022
Russian Federation


N. V. Isaeva
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia 1, Partisan Zheleznyak St., Krasnoyarsk 660022 Territorial Clinical Hospital, Krasnoyarsk, Russia 3, Partisan Zheleznyak St., Krasnoyarsk 660022
Russian Federation


V. A. Shnayder
Territorial Clinical Hospital, Krasnoyarsk, Russia 3, Partisan Zheleznyak St., Krasnoyarsk 660022
Russian Federation


Yu. S. Panina
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia 1, Partisan Zheleznyak St., Krasnoyarsk 660022
Russian Federation


A. V. Dyuzhakova
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia 1, Partisan Zheleznyak St., Krasnoyarsk 660022
Russian Federation


S. K. Dyuzhakov
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia 1, Partisan Zheleznyak St., Krasnoyarsk 660022
Russian Federation


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For citation:


Popova T.E., Shnayder N.A., Petrova M.M., Nikolaeva T.Y., Kantimirova E.A., Isaeva N.V., Shnayder V.A., Panina Y.S., Dyuzhakova A.V., Dyuzhakov S.K. Herpesvirus-associated central and peripheral nervous system involvement: two clinical cases. Neurology, Neuropsychiatry, Psychosomatics. 2015;7(2):28-34. (In Russ.) https://doi.org/10.14412/2074-2711-2015-2-28-34

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ISSN 2074-2711 (Print)
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