Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Brain bioelectrical activity changes in patients with poststroke depression and apathy

https://doi.org/10.14412/2074-2711-2015-2-10-15

Full Text:

Abstract

Objective: to study the specific features of brain bioelectrical activity in patents with poststroke apathy and depressive disorders.

Patients and methods. The investigation enrolled 175 patients (84 men and 91 women) with new-onset cerebral stroke at different sites. A total of 107 (61%) patients of them were observed to have depressive disorders (n=41 (38%)) and apathy (n=66 (62%)) within a year after disease onset. A control group included 68 (39%) patients without poststroke affective disorders. The mean age of the study group patients was 66±10 years and that of the control patients was 68±11 years. The severity and magnitude of neurological deficit were evaluated using the U.S. National Institutes of Health Stroke Scale (NIHSS). The patients underwent electroencephalography (EEG), brain computed tomography and magnetic resonance imaging. The investigators used diagnostic and statistical manual of mental disorders (DSM-IV) criteria to diagnose depression and the Hamilton depression rating scale (HAM-D) and the mini-mental status examination (MMSE) to evaluate the mental status. The basic rhythmic power indices in the affected and unaffected hemispheres were calculated, as well as anteroposterior alpha rhythm distribution coefficient and interhemispheric asymmetry coefficient. 

Results and discussion. The computer EEG analysis was shown to identify the hallmark characteristics of brain bioelectric activity in patients with different types of affective disorders in the acute, early and late recovery periods of stroke. The patients with affective disorders were found to have brain bioelectrical activity changes predominantly in the rapid frequency sub-band on EEG, suggesting midbrain structural dysfunction. In the patients with poststroke depression, depressive disorder scale scores were related to the power of bioelectric activity in the slow and alpha frequency bands manly in the acute stroke period whereas those were correlated with the EEG beta band power in the delayed period.

About the Authors

I. V. Kichuk
Department of Fundamental and Clinical Neurology and Neurosurgery, Research Institute of Cerebrovascular Pathology and Stroke, N.I. Pirogov Russian National Research Medical University, Moscow, Russia 1, Ostrovityanov St., Moscow 117513
Russian Federation


E. A. Petrova
Department of Fundamental and Clinical Neurology and Neurosurgery, Research Institute of Cerebrovascular Pathology and Stroke, N.I. Pirogov Russian National Research Medical University, Moscow, Russia 1, Ostrovityanov St., Moscow 117513
Russian Federation


N. A. Georgievskaya
Department of Fundamental and Clinical Neurology and Neurosurgery, Research Institute of Cerebrovascular Pathology and Stroke, N.I. Pirogov Russian National Research Medical University, Moscow, Russia 1, Ostrovityanov St., Moscow 117513
Russian Federation


References

1. Боголепова АН. Депрессивные расстройства у больных с цереброваскулярной патологией. В кн.: Справочник поликлинического врача. Москва; 2003. С. 23–7. [Bogolepova AN. Depressive disorders in patients with cerebrovascular disease. In: Spravochnik poliklinicheskogo vracha [Directory of outpatient physician]. Moscow; 2003. P. 23–7.]

2. Давыдов АТ, Литвинцев СВ, Бутко ДЮ и др. Опыт диагностики и лечения тревожного расстройства в постинсультном периоде у больных, перенесших ишемический инсульт. Русский Медицинский Журнал. 2008;(5):266–70. [Davydov AT, Litvintsev SV, Butko DYu, et al. The experience of diagnosis and treatment of anxiety disorders in poststroke period in patients after ischemic stroke. Russkii Meditsinskii Zhurnal. 2008;(5):266–70. (In Russ.)].

3. Вейн АМ, Вознесенская ТГ, Голубев ВЛ, Дюкова ГМ. Депрессии в неврологической практике. Москва: МИА; 2007. 208 с. [Vein AM, Voznesenskaya TG, Golubev VL, Dyukova GM. Depressii v nevrologicheskoi praktike [Depression in neurological practice]. Moscow: MIA; 2007. 208 p.]

4. Narushima K, Kosier JT, Robinson RG. A reappraisal of poststroke depression, intraand inter-hemispheric lesion location using meta-analysis. J Neuropsychiatry Clin Neurosci. 2003 Fall;15(4):422–30.

5. Парфенов ВА. Постинсультная депрессия: распространенность, патогенез, диагностика и лечение. Неврология, нейропсихиатрия, психосоматика. 2012;4(4):84–8. [Parfenov VA. Poststroke depression: prevalence, pathogenesis, diagnosis, and treatment. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2012;4(4):84–8. (In Russ.)]. DOI: http://dx.doi.org/10.14412/2074-2711- 2012-428

6. Бочкарев ВК, Панюшкина СВ. Электроэнцефалографические исследования при пограничных состояниях. В кн.: Пограничные психические расстройства. Москва; 2000. С. 120–33. [Bochkarev VK, Panyushkina SV. Electroencephalographic studies in the border states. In: Pogranichnye psikhicheskie rasstroistva [Borderline mental disorders]. Moscow; 2000. P. 120–33.]

7. Петрова ЕА, Савина МА, Георгиевская НА и др. Постинсультные аффективные расстройства. Журнал неврологии и психиатрии им. С.С. Корсакова. 2011;(10):12–7. [Petrova EA, Savina MA, Georgievskaya NA, et al. Post-stroke affective disorders. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2011;(10):12–7. (In Russ.)].

8. Mayberg HS. Frontal lobe dysfunction in secondary depression. J Neuropsychiatry Clin Neurosci. 1994 Fall;6(4):428–42.

9. Murphy BE. Steroids and depression. J Steroid Biochem Mol Biol. 1991 May;38(5):537–59.

10. Ressler KJ, Nemeroff CB. Role of serotonergic and noradrenergic systems in the athophysiology of depression and anxiety disorders. Depress Anxiety. 2000;12 Suppl 1:2–19.

11. Петрова ЕА, Брусов ОС, Кичук ИВ. Патогенетические аспекты развития депрессивных и тревожных расстройств у больных с церебральным инсультом. Нервые болезни. 2014;(1):26–31. [Petrova EA, Brusov OS, Kichuk IV. Pathogenetic aspects of the development of depressive and anxiety disorders in patients with cerebral stroke. Nervye bolezni. 2014;(1):26–31. (In Russ.)].

12. Shakesby AC, Anwyl R, Rowan MJ. Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antide pressant agents. J Neurosci. 2002 May 1;22(9):3638–44.

13. Пирлик ГП, Скворцова ВИ, Гнездицкий ВВ. Разработка системы контроля функционального состояния головного мозга больных с инсультами полушарной локализации на основе методов картирования и трехмерной локализации источников ЭЭГ. Москва; 2000. 107 с. [Pirlik GP, Skvortsova VI, Gnezditskii VV. Razrabotka sistemy kontrolya funktsional'nogo sostoyaniya golovnogo mozga bol'nykh s insul'tami polusharnoi lokalizatsii na osnove metodov kartirovaniya i trekhmernoi lokalizatsii istochnikov EEG [Development of a system for monitoring the functional state of the brain of patients with hemispheric stroke localization on the basis of methods of three-dimensional mapping and ocalization of EEG sources]. Moscow; 2000. 107 p.]

14. Robinson RG, Starkstein SE. Current research in affective disorders following stroke. J europsychiatry Clin Neurosci. 1990 Winter;2(1):1–14.

15. Yamada M, Kimura M, Mori T, Endo S. EEG power and coherence in presenile and senile depression. Characteristic findings related to differences between anxiety type and etardation type. Nihon Ika Daigaku Zasshi. 1995 Apr;62(2):176–85.

16. Савина МА, Петрова ЕА. Соотношение постинсультных депрессий с другими постинсультными психическими расстройствами. Материалы IV Международного конгресса «Нейрореабилитация-2012». Москва; 2012. С. 98–9. [Savina MA, Petrova EA. Sootnoshenie postinsul'tnykh depressii s drugimi postinsul'tnymi psikhicheskimi asstroistvami. Materialy IV Mezhdunarodnogo kongressa «Neiroreabilitatsiya-2012» [The ratio of poststroke depression with other post-stroke mental disorders. Proceedings of the IV International Congress «Neurorehabilitation-2012»]. Moscow; 2012. P. 98–9.]

17. Изнак АФ, Чаянов НВ. Модуляция сенсомотроной деятельности человека на фоне альфа ритма. В кн.: Проблемы развития научных исследований в области психического здоровья. Москва: ВНЦПЗ АМН СССР; 1989. С. 3–24. [Iznak AF, Chayanov NV. Modulation of sensomotoric human activities on the background alpha rhythm. In: Problemy razvitiya nauchnykh issledovanii v oblasti psikhicheskogo zdorov'ya [Problems of development of scientific research in the field of mental health]. Moscow: VNTsPZ AMN SSSR; 1989. P. 3–24]

18. McAllister-Williams RH, Alhaj HA, Massey A, et al. Somatodendritic 5- ydroxytryptamine1A (5-HT1A) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone. Psychol Med. 2014 Mar;44(4):767–77. doi: 10.1017/S0033291713001475. Epub 2013 Jul 1.

19. Lieber AL. Diagnosis and subtyping of depressive disorders by quantitative lectroencephalography. Hillside J Clin Psychiatry. 1988;10(1):84–97.

20. Ohmatsu S, Nakano H, Tominaga T, et al. Activation of the serotonergic system by edaling exercise changes anterior cingulate cortex activity and improves negative emotion. Behav Brain Res. 2014 Aug 15;270:112–7. doi: 10.1016/j.bbr.2014.04.017. Epub 2014 May 6.

21. Kostyalik D, Kаtai Z, Vas S, et al. Chronic escitalopram treatment caused dissociative adaptation in serotonin (5-HT) 2C receptor antagonist-induced effects in REM sleep, wake and theta wave activity. Exp Brain Res. 2014 Mar;232(3):935–46. doi: 10.1007/s00221-013- 3806-8. Epub 2014 Jan 7.

22. Maletic V, Robinson M, Oakes T, et al. Neurobiology of depression: an integrated view of key findings. Int J Clin Pract. 2007 Dec;61(12):2030–40. Epub 2007 Oct 17.

23. Drevets WC. Neuroplasticity in mood disorders. Dialogues Clin Neurosci. 2004 Jun;6(2):199–216.

24. Muthukumaraswamy SD. The use of magnetoencephalography in the study of psychopharmacology (pharmaco-MEG). J Psychopharmacol. 2014 Sep;28(9):815–29. doi: 10.1177/0269881114536790. Epub 2014 Jun 11.


For citation:


Kichuk I.V., Petrova E.A., Georgievskaya N.A. Brain bioelectrical activity changes in patients with poststroke depression and apathy. Neurology, Neuropsychiatry, Psychosomatics. 2015;7(2):10-15. (In Russ.) https://doi.org/10.14412/2074-2711-2015-2-10-15

Views: 996


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)