Visual evoked potentials in examining the visual analyzer in patients with multiple sclerosis
Abstract
Objective: to study the neurophysiological features of the visual analyzer in patients with multiple sclerosis (MS) to optimize the early diagnosis of the disease.
Patients and methods. Seventy-nine patients (57 women and 22 men, mean age 34.31±4.7 years) diagnosed as having MS were examined. The mean duration of the disease with consideration for its clinical form was 3.3±2.2 years in relapsing-remitting MS (RRMS), 9.1±4.2 years in secondary progressive MS (SPMS), and 2.7±1.9 years in primary progressive MS (PPMS).
Results and discussion. The neurophysiological examination indicated that demyelination processes in MS proceeded differently in response to dissimilar lights in the structures of the visual analyzer. The most marked significant (p<0.01) deviations in the values of visual evoked potentials (VEPs) to the black-white tessellated pattern (TP) were observed in the patients with SPMS and in those with PPMS. The latency of the P100 wave increased dramatically and differed significantly (p<0.001) from those in the control group (127.09 msec for RRMS, 128.3 msec for SPMS, 124.5 msec for PPMS, and 106.1 msec in the control). Amplitude analysis could reveal a significant decrease in the force of a N75–N100 wave response to the black-white stimulus in all the clinical groups, averaging 3.3 μW (8.5 μW in the control). The latency of the P100 wave to the red-yellow TP increased considerably and differed significantly (p<0.001) from that in the control group, by comprising
147.29±1.19 msec for RRMS, 150.23±1.49 msec for SPMS, and 144.38±2.11 msec for PPMS. There were the same changes that to the greenblack TP. Examination of 25 patients with MS established higher levels of IgG antibodies against myelin basic protein. The most significant latency increase occurs in response to the color spectrum of visible light against the black-white background, which may serve as an early diagnostic criterion for MS. These changes lead to a sharp decrease in a cortical feedback. The use of the color pattern will largely contribute to the improved early diagnosis of MS.
About the Authors
S. M. Karpov
Stavropol State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Stavropol, Russia 310, Mir St., Stavropol 355017
Z. B. Pazhigova
Stavropol State Medical University, Ministry of Health of Russia
Russian Federation
Stavropol, Russia 310, Mir St., Stavropol 355017
Russian Federation
Stavropol, Russia 310, Mir St., Stavropol 355017
E. N. Karpova
Stavropol State Medical University, Ministry of Health of Russia
Russian Federation
Stavropol, Russia 310, Mir St., Stavropol 355017
Russian Federation
Stavropol, Russia 310, Mir St., Stavropol 355017
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Review
For citations:
Karpov S.M., Pazhigova Z.B., Karpova E.N. Visual evoked potentials in examining the visual analyzer in patients with multiple sclerosis. Neurology, Neuropsychiatry, Psychosomatics. 2014;6(3):27-31. (In Russ.) https://doi.org/10.14412/2074-2711-2014-3-27-31
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