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Clinical case of Spina bifida in a Child Born to a Mother with Epilepsy Receiving Carbamazepine

https://doi.org/10.14412/2074-2711-2014-1S-39-44

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Abstract

This article presents a literature review on teratogenic effects of carbamazepine and a clinical case of spina bifida in a child whose mother had epilepsy and was receiving carbamazepine during pregnancy. 

About the Authors

E. O. Ovchinnikova
Children’s City Hospital No125, Moscow Health Department Northeastern administrative district, Moscow, Moscow
Russian Federation


M. B. Mironov
St. Luka's Institute of Child Neurology and Epilepsy, Moscow
Russian Federation


K. Yu. Mukhin
St. Luka's Institute of Child Neurology and Epilepsy, Moscow
Russian Federation


T. M. Krasil’shchikova
Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, Moscow
Russian Federation
Division of Neurology, Neurosurgery and Medical Genetics, Pediatric Department


D. N. Smirnov
Perinatal Center, City Clinical Hospital No7, Moscow
Russian Federation


References

1. Aicardi J. Epilepsy in children. In: Procopis PG, Rapin I, editors. The International Review of Child Neurology. New York: Raven Press; 1994.

2. Guberman AH, Bruni, J. Essentials of Clinical Epilepsy. 2nd ed. Boston: Butterworth Heinemann; 1999. P. 3–10.

3. Власов ПН, Карлов ВА, Петрухин АС, Болотнов МА. Медикаментозная терапия эпилепсии у беременных. Фарматека. Меж- дународный медицинский журнал. 2005;(9):38–43. [Vlasov PN, Karlov VA, Petrukhin AS, Bolotnov MA. Medikamentoznaya terapiya epilepsii u bere- mennykh. Farmateka.IMM International Medical Magazine. 2005;(9):38–43.]

4. Карлов ВА. Эпилепсия у детей и взрос- лых женщин и мужчин: Руководство для врачей. Москва: Медицина; 2010.

5. [Karlov VA. Epilepsiya u detei i vzroslykh zhen- shchin i muzhchin: Rukovodstvo dlya vrachei. Moscow: Meditsina; 2010.]

6. Стуров НВ. Эпилепсия и беременность: контроль тератогенности противоэпилепти- ческих препаратов. Трудный пациент. 2007;5(1):50–4. [Sturov NV. Epilepsiya i bere- mennost': kontrol' teratogennosti protivoepilep- ticheskikh preparatov. Trudnyi patsient. 2007;5(1):50–4.]

7. Жидкова ИА. Гендерные аспекты эпилеп- сии. Вестник эпилептологии. 2013;(1):8–12. [Zhidkova IA. Gendernye aspekty epilepsii. Vestnik epileptologii. 2013;(1):8–12.]

8. Ушкалова ЕА. Проблемы безопасности лекарственных средств во время беременно- сти. Трудный пациент. 2005;3(2):4–6. [Ushkalova EA. Problemy bezopasnosti lekarstvennykh sredstv vo vremya beremennosti. Trudnyi patsient. 2005;3(2):4–6.]

9. Власов ПН. Беременность при эпилеп- сии. Эпилепсия и пароксизмальные состоя- ния. 2009;1(1):8–13. [Vlasov PN. Pregnancy in epilepsy. Epilepsiya i paroksizmal'nye sostoy- aniya. 2009;1(1):8–13.]

10. Holmes LB, Wyszynski DF. North American antiepileptic drug pregnancy registry. Epilepsia.

11. ;45(11):1465. DOI: http://dx.doi.org/10.1111/j.0013- 9580.2004.451102.x.

12. Vajda F, Lander C, O’Brien T, et al. Australian pregnancy registry of women taking antiepileptic drugs. Epilepsia. 2004;45(11):1466. DOI: http://dx.doi.org/10.1111/j.0013- 9580.2004.451103.x.

13. Шток ВН. Фармакотерапия в невроло- гии. Практическое руководство. Москва: Медицинское информационное агентство (МИА); 2010. 536 с. [Shtok VN. Farmakoterapiya v nevrologii. Prakticheskoe rukovodstvo. Moscow: Meditsinskoe informat- sionnoe agentstvo (MIA); 2010. 536 p.]

14. Петрухин АС. Клиническая детская нев- рология. Руководство. Москва: Медицина; 2008. 1088 с. [Petrukhin AS. Klinicheskaya det- skaya nevrologiya. Rukovodstvo. Moscow: Meditsina; 2008. 1088 p.]

15. Воронкова КВ, Пылаева ОА, Косякова ЕС и др. Современные принципы терапии эпилепсии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2010;110(6):24–36. [Voronkova KV, Pylaeva OA, Kosiakova ES, et al. Modern principles of epilepsy therapy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2010;110(6):24–36.]

16. Harden CL, Pennell PB, Koppel BS, et al. Practice parameter update: management issues for women with epilepsy-focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology. 2009;73(2):142–9. DOI: 10.1212/WNL.0b013e3181a6b325. Epub 2009 Apr 27.

17. Кожокару АБ, Карлов ВА, Жидкова ИА, Серкина АВ. Стигмы дизэмбриогенеза и физическое развитие у детей, рожденных от матерей, страдающих эпилепсией. Журнал неврологии и психиатрии имени С.С. Корсакова. 2011;111(S5):52–7. [Kozhokaru AB, Karlov VA, Zhidkova IA, Serkina AV. Stigmy dizembriogeneza i fizicheskoe razvitie u detei, rozhdennykh ot materei, stradayushchikh epilepsiei. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2011;111(S5):52–7.]

18. Eroglu E, Gö kcil Z, Bek S, et al. Pregnancy and teratogenicity of antiepileptic drugs. Acta Neurol Belg. 2008;108(2):53–7.

19. Школьник ВМ, Бараненко АН, Кальбус АИ. Беременность и эпилепсия. Международный неврологический журнал. 2010;6(36):135–7. [Shkolnik VM, Baranenko AN, Kalbus AI. Pregnancy and Epilepsy. Mezhdunarodnyi nevrologicheskii zhurnal. 2010;6(36):135–7.]

20. Matalon S, Schechtman S, Goldzweig G, Ornoy A. The teratogenic effect of carba- mazepine: a meta-analysis of 1255 exposures. Reprod Toxicol. 2002;16(1):9–17. DOI: http://dx.doi.org/10.1016/S0890- 6238(01)00199-X.

21. Kirke PN, Molloy AM, Daly LE, et al. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med. 1993;86(11):703–8.

22. Morrow J, Russell A, Guthrie E, et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry. 2006;77(2):193–8. DOI: http://dx.doi.org/10.1136/jnnp.2005.074203.

23. Assaad F., Hasan K., Saleh Y. Effects of car- bamazepine on serum levels of folic acid and homocystein. Pan Arab J Neurosurgery. 2010;14(1):108–11.

24. Jentink J, Dolk H, Loane MA, et al. Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study. BMJ. 2010;341:6581. DOI: 10.1136/bmj.c6581.

25. Wald N. Prevention of neural tube defects: results of the Medical Research Council Vitamin study. Lancet.1991;338(8760):131–7. DOI: http://dx.doi.org/10.1016/0140- 6736(91)90133-A.

26. Berry RJ, Li Z, Erickson JD, et al. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med. 1999;341(20):1485–90. DOI: http://dx.doi.org/10.1056/NEJM1999111134 12001.

27. Mosley BS, Hobbs CA, Flowers BS, et al. Folic acid and the decline in neural tube defects in Arkansas. J Ark Med Soc. 2007 Apr;103(10):247–50.

28. Hernandez-Diaz S, Werler MM, Walker AM, Mitchell AA. Neural Tube Defects in Relation to Use of Folic Acid Antagonists during Pregnancy. Am J Epidemiol. 2001;153(10):961–8. DOI: http://dx.doi.org/10.1093/aje/153.10.961.

29. Jones KL, Lacro RV, Johnson KA, Adams J. Pattern of Malformations in the Children of Women Treated with Carbamazepine during Pregnancy. N Engl J Med. 1989;320(25):1661–6. DOI: http://dx.doi.org/10.1056/NEJM198906223202 505.

30. Afshar M. Preventive effect of vitamin B6 on developmental toxicity of carbamazepine in mice. Iranian J Basic Med Scien. 2011;14(2):99–106.

31. Dodd S, Berk M. The safety of medica- tions for the treatment of bipolar disorder during pregnancy and the puerperium. Curr Drug Saf. 2006;1(1):25–33. DOI: http://dx.doi.org/10.2174/157488606775252 692.

32. Werler MM, Ahrens KA, Bosco JL, et al. Use of antiepileptic medications in pregnancy in relation to risks of birth defects. Ann Epidemiol. 2011;21(11):842–50. DOI: http://dx.doi.org/10.1016/j.annepi- dem.2011.08.002.

33. Никифоров АС, Коновалов АН, Гусев ЕИ. Клиническая неврология. Т. 1. Москва: Медицина; 2002. С. 531–4. [Nikiforov AS, Konovalov AN, Gusev EI. Klinicheskaya nevrologiya. T. 1. Moscow: Meditsina; 2002. P. 531–4.]

34. Еликбаев ГМ, Хачатрян ВА, Карабеков АК. Врожденные спинальные па- тологии у детей. Шымкент: ЮКГМА; 2008; 80 с. [Elikbaev GM, Khachatryan VA, Karabekov AK. Vrozhdennye spinal'nye patologii u detei. Shymkent: YuKGMA; 2008; 80 p.]

35. Rosa F. Spina bifida in infants of women treated with carbamazepine during pregnancy. N Engl J Med. 1991;324(10):674–7. DOI: http://dx.doi.org/10.1056/NEJM19910307324 1006.

36. Carrie L, Ernst MD, Joseph F. Goldberg MD. The reproductive safety profile of mood stabiliz- ers, atypical antipsychotics, and broad-spec- trum psychotropics. J Clin Psychiatry. 2002;63 Suppl 4:42–55.

37. Battino D, Tomson T. Management of epilepsy during pregnancy. Drugs. 2007;67(18):27–46. DOI: http://dx.doi.org/10.2165/00003495- 200767180-00007.

38. Бочкарева ЕВ, Холодова ИН, Коваль ГС и др. Влияние эпилепсии и антиэпилепти- ческой терапии на репродуктивную функ- цию женщин и состояние здоровья детей, родившихся у женщин с эпилепсией: основ- ные факторы риска (обзор литературы). Русский журнал детской неврологии. 2011;6(4):27–46. [Bochkareva EV,

39. Kholodova IN, Koval GS, et al. Influence of epilepsy and antiepileptic therapy on reproduc- tive health and the health of children, who were born from women with epilepsy: main rist fac- tors (a review). Russkii zhurnal detskoi nevrologii. 2011;6(4):27–46.]


For citation:


Ovchinnikova E.O., Mironov M.B., Mukhin K.Yu., Krasil’shchikova T.M., Smirnov D.N. Clinical case of Spina bifida in a Child Born to a Mother with Epilepsy Receiving Carbamazepine. Neurology, Neuropsychiatry, Psychosomatics. 2014;6(1S):39-44. (In Russ.) https://doi.org/10.14412/2074-2711-2014-1S-39-44

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