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Clinical topographical correlation upon brain tumors in children

https://doi.org/10.14412/2074-2711-2014-1-21-25

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Abstract

The aim of the study was to explore the most characteristic clinical manifestations of brain tumors in children, depending on their localization, and to detect the earliest of them.
Patients and methods. A total of 56 children (32 boys and 24 girls) with brain tumor, aged from 1.5 months to 15 years, were examined. The time elapsed between the onset of disease to the emergence of clinical symptoms was assessed. Neurological symptomatology was compared to the localization of a tumor diagnosed using neuroimaging techniques (computed tomography or magnetic resonance imaging) and during surgery. Surgery was performed in 18 children (in all of them, localization of the process was observed in the posterior cranial fossa, PCF). Results. The highest incidence of brain tumors was revealed in children aged 3–13 years; most patients became ill at the age between 3 and 6 years.
Tumors of the PCF predominated in terms of their localization (67.9% of cases). Intracerebral tumors of the hemispheres or vermis were observed in most (63.2%) patients with tumors of the PCF.
In 11 (61%) of the 18 operated children with subtentorial tumors, astrocytomas of various degrees of differentiation and medulloblastomas were detected using the histological examination. Tumors of the IV ventricle were ependymal. Tumors of the cerebral hemispheres (19.6%), of the pineal and chiasmosellar regions (8.9%) predominated among supratentorial tumors.
The time between the emergence of initial symptoms of a disease and admission to hospital ranged from 1 month to 3 years. The most characteristic and earliest symptoms for tumors of the PCF and brain ventricles were headache, nausea and vomiting. For tumors of the cerebellar vermis and hemispheres, these symptoms included impairment of the coordination of movements and the muscle tone change. For brain stem tumors, these symptoms included dysfunction of the cranial nerves. For tumors of the cerebral hemispheres, these were seizures and motor and sensory disturbances in the limbs. 

About the Authors

A.M. Dolgov
Department of Neurology and Medical Genetics, Orenburg State Medical Academy, the Ministry of Health of the Russian Federation, Orenburg, Russia;
Russian Federation


S.V. Ishkov
Regional Clinical Hospital, Department of Neurosurgery, Orenburg, Russia
Russian Federation


N.V. Aptikeeva
Department of Neurology and Medical Genetics, Orenburg State Medical Academy, the Ministry of Health of the Russian Federation, Orenburg, Russia
Russian Federation


T.M. Yakubova
Department of Neurology and Medical Genetics, Orenburg State Medical Academy, the Ministry of Health of the Russian Federation, Orenburg, Russia; Regional Children Clinical Hospital, Orenburg, Russia
Russian Federation


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For citation:


Dolgov A., Ishkov S., Aptikeeva N., Yakubova T. Clinical topographical correlation upon brain tumors in children. Neurology, Neuropsychiatry, Psychosomatics. 2014;6(1):21-25. (In Russ.) https://doi.org/10.14412/2074-2711-2014-1-21-25

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)