Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Experience in using sulpiride in non-psychotic endogenous depressive-hypochondriacal disorders

https://doi.org/10.14412/2074-2711-2012-365

Full Text:

Abstract

Objective: to study the efficacy of sulpiride in different types of non-psychotic types of endogenous depressive-hypochondriacal syndrome. Patients and methods. Forty-seven patients (36 women and 11 men) with a depressive episode (n = 15), recurrent depressive disorder (n = 14), and slowly progressive schizophrenia (SPS) (n = 18) were examined clinically and using the psychometric scales: the Clinical Global Impression Scale; Montgomery-Esberg Depression Rating Scale (MADRS), the Hamilton Anxiety Rating Scale (HARS), and Udvalg for Kliniske Undersшgelser Side Effect Rating Scale. Sulpiride was given in an initial dose of50—100 mg/day; the dose was, if required, increased up to 400—600 mg/day. Results. After 2 months of treatment in the patients with affective disorders, the MADRS and HARS scores showed reductions from 28.7+2.3 to 14.3+1.7 and from 14.8+2.1 to 7.4+2.7, respectively. The reductions in the symptoms of depression and anxiety were 50.2 and 50.0%, respectively. In SPS, the mean MADRS and HARS scores decreased from 21.4+3.7 to 13.7ё1.8 and from 10.2+1.5 to 6.4+3.2, respectively. There were generally 40 and 37.3% reductions in the symptoms of depression and anxiety, respectively. Conclusion. In patients with affective disorders, the efficacy of sulpiride is predominantly due to its antidepressant and anti-anxiety activities in depressive-hypochondriacal syndrome and to its antipsychotic and activating activities in SPS.

About the Authors

Nina Arkadyevna Tyuvina

Department of Psychiatry and Medical Psychology


V. V. Balabanova

Department of Psychiatry and Medical Psychology


E M Goncharova

Department of Psychiatry and Medical Psychology


References

1. <div><p>Блейлер Э. Руководство по психиатрии. Берлин: Врачь, 1920;128.</p><p>Карвасарский В.Д. Неврозы. Рук-во для врачей. М.: Медицина, 1980;448 с.</p><p>Свядощ А.М. Неврозы. Изд. 3-е. М.: Медицина, 1982;367 с.</p><p>Снежневский А.В. Клиническая психопатология. В кн.: Руководство по психиатрии. Т. 1, 2. М.: Медицина, 1983;16-97.</p><p>Чан Вьет Нги, Тювина Н.А. Клинические закономерности формирования ипохондрических расстройств в рамках различных психических заболеваний. Журн неврол и психиатр 1987;6:880-5.</p><p>Тювина Н.А., Прохорова С.В., Максимова Т.Н. Эффективность и особенности действия сульпирида при вялотекущей шизофрении. Журн псих расстр в общ мед 2011;1:51-6.</p><p>Волель Б.А. Небредовая ипохондрия (обзор литературы). Журн псих расстр в общ мед 2009;2:49-62.</p><p>Sattes H. Die Hypochondrische Depression. Halle, 1955;82S.</p><p>Овсянников С.А. История и эпистемология пограничной психиатрии. М.: Альпари, 1995;205 с.</p><p>Авербух Е.С. Рaсстройства психической деятельности в позднем возрасте. Л.: Медицина, 1969;483 с.</p><p>Lopes Ibor J.J., Depressive equivalents. In: Masked depression. Stuttgart, 1973;97—112.</p><p>Ануфриев А.К. Скрытые эндогенные депрессии. Сообщение II: клиническая симптоматика. Журн невропат и психиатр 1978;9:1202-8.</p><p>Weitbrecht H.J. Depressive und Manische endogene Psychosen. In: Psychiatrie der Gegenwart. Bd.II/1. Berlin—Heidelberg—New York, 1972;83—140.</p><p>Serra G., Forgione A., D’Aguila P.S. Possible mechanism of antidepressant effect of L-sulpiride. Clin Neuropharmacol 1990;13(1):76—83.</p><p>Смирнова М.Л., Мунчаева Э.Р., Тихонов В.В. Применение эглонила в психиатрической практике. Клин вестн 1994;2:35-7.</p><p>Дробижев М.Ю. Сульпирид: механизм действия и возможность клинического использования. Психиатр и психофармакотер 2004;6(4):173-9.</p><p>Petit M., Zann M., Lesieur P. et al. The effect of sulpiride on negative symptoms of schizophrenia. Br J Psychiatry 1987;150:270-1.</p><p>Kawakami K., Sasaki D., Sobma M. et al. Experience with Dogmatyl (sulpiride) in psychosomatic disease and neurosis. II Results of a double blind study (in Japanese). Med Treatment 1974;7:69-78.</p><p>Костюкова Е.Г. Сульпирид (эглонил) в лечении острых и хронических психозов. Соц и клин психиатр 2001;2:24-8.</p><p>Mucci A., Nolfe G., Maj M. Levosulpiride: a review of its clinical use in psychiatry. Pharmacol Res 1995;31(2):95-101.</p></div><br />


For citation:


Tyuvina N.A., Balabanova V.V., Goncharova E.M. Experience in using sulpiride in non-psychotic endogenous depressive-hypochondriacal disorders. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(1):67-71. (In Russ.) https://doi.org/10.14412/2074-2711-2012-365

Views: 507


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)