Personalized therapy of chronic pain syndromes in patients with multiple sclerosis

In patients with multiple sclerosis (MS), chronic pain syndromes (CPS), which vary in terms of their etiology, clinical symptoms and localization, occur with high frequency even in the early stages of the disease. As a rule, these are pathogenetically linked to the underlying disease and result from focal lesions in the central nervous system and/or the neurological disorders developing in patients. CPS significantly reduce quality of life, impair social adaptation and exacerbate disability in patients with MS. This article provides a brief overview of the pathogenesis, clinical manifestations and diagnostic principles of the CPS most commonly observed in patients with MS (central neuropathic pain, trigeminal neuralgia, Lhermitte's sign, painful tonic spasms, spasticity pain). Particular attention is paid to modern approaches to the treatment of CPS in patients with MS, management strategies tailored to the individual characteristics of the course of CPS and the 'response' to therapy, as well as the presence of comorbid psycho-emotional disorders and associated somatic pathology.

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