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Fortelyzin in the treatment of acute ischemic stroke due to basilar-artery occlusion: data from the observational study FORPI registry

https://doi.org/10.14412/2074-2711-2026-2-36-44

Abstract

   The approach to reperfusion therapy for acute ischemic stroke (AIS) in cases of basilar artery occlusion (BAO) remains a matter of debate.

   Objective: to assess the safety and efficacy of Fortelyzin in patients with BAO in real-world clinical practice, based on data from the FORPI registry.

   Material and methods. The FORPI registry is an open-label, prospective, non-interventional observational study of Fortelyzin in patients with ischaemic stroke. An analysis was conducted of the safety and efficacy of Fortelyzin in a group of patients with basilar artery occlusion who underwent intravenous thrombolytic therapy (IVT) and bridging therapy. The safety endpoint was the incidence of symptomatic intracranial haemorrhage (SICH) as defined by ECASS III and SITS-MOST, as well as all-cause mortality at 90 days. The efficacy endpoint was defined as good functional recovery, defined as a score of 0–2 on the modified Rankin Scale (MRS) at 90 days.

   Results. This analysis included 1910 patients who underwent IVT and 53 patients who underwent bridging therapy. The median National Institutes of Health Stroke Scale (NIHSS) scores at admission were 9 and 12 points, respectively (p = 0.01). SICH incidence (ECASS III criteria) was significantly higher in the bridging therapy group compared to IVT group (6 % vs 1 %, p = 0.01). All-cause mortality at day 90 did not differ significantly between the groups (9 % and 7 %, respectively, p = 0.52). Good functional recovery at day 90 was achieved by 69 % of patients in the IVT group and 60 % of patients in the bridging therapy group (p = 0.31).

   Conclusion. The use of Fortelyzin in AIS patients with BAO may be considered an effective and safe form of reperfusion therapy, as well as a component of bridging therapy aimed at increasing the number of favorable functional outcomes.

About the Authors

N. A. Shamalov
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of Russia
Russian Federation

Nikolay Anatolyevich Shamalov

117997; 1, Ostrovityanova St.; 1, Ostrovityanova St., Build. 10; Moscow


Competing Interests:

There are no conflicts of interest. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors



M. Yu. Martynov
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of Russia
Russian Federation

117997; 1, Ostrovityanova St.; 1, Ostrovityanova St., Build. 10; Moscow


Competing Interests:

There are no conflicts of interest. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors



N. A. Marskaya
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

117997; 1, Ostrovityanova St.; Moscow


Competing Interests:

There are no conflicts of interest. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors



D. R. Khasanova
Kazan State Medical University, Ministry of Health of Russia
Russian Federation

420012; 49, Butlerova St.; Kazan


Competing Interests:

There are no conflicts of interest. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors



E. B. Yarovaya
M.V. Lomonosov Moscow State University
Russian Federation

119991; 1, Leninskie Gory; Moscow


Competing Interests:

There are no conflicts of interest. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors



I. A. Voznuk
Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation

197022; 6-8, L'va Tolstogo St.; St. Petersburg


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There are no conflicts of interest. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors



L. V. Timchenko
Research Institute – S.V. Ochapovsky Regional Clinical Hospital No. 1
Russian Federation

350086; 167, 1 Maya St.; Krasnodar


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A. M. Alasheev
Sverdlovsk State Regional Clinical Hospital No 1
Russian Federation

620102; 185, Volgogradskaya St.; Yekaterinburg 


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N. V. Khalo
I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital No. 20
Russian Federation

660123; 12, Instrumentalnaya St.; Krasnoyarsk


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M. D. Bogatyreva
Stavropol Regional Clinical Hospital
Russian Federation

355029; 1, Semashko St.; Stavropol


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D. S. Khan
Primorsky Regional Clinical Hospital No. 1
Russian Federation

690091; 57, Aleutskaya St.; Vladivostok


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L. L. Korsunskaya
V.I. Vernadsky Crimean Federal University
Russian Federation

295007; 4, Akademika Vernadskogo Prosp.; Simferopol


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V. N. Nesterova
N.A. Semashko Nizhny Novgorod Regional Clinical Hospital
Russian Federation

603093; 190, Rodionova St.; Nizhny Novgorod


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Zh. Yu. Chefranova
Belgorod State National Research University
Russian Federation

308015; 85, Pobedy St.; Belgorod


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T. V. Kharitonova
I.I. Dzhanelidze St. Petersburg Research Institute of Emergency Medicine
Russian Federation

192242; 3, Budapeshtskaya St., lit. A; Saint Petersburg


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M. V. Sutormin
M.F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation

129110; 61/2, Shchepkina St.; Moscow


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O. E. Furman
M.F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation

129110; 61/2, Shchepkina St.; Moscow


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A. A. Kulesh
Acad. E.A. Vagner Perm State Medical University, Ministry of Health of Russia; City Clinical Hospital Four
Russian Federation

614990; 26, Petropavlovskaya St.; 614107; 2, KIM St.; Perm


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N. V. Zhukovskaya
Leningrad Regional Clinical Hospital
Russian Federation

194291; 45/2, Lunacharskogo Prosp.; St. Petersburg


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K. V. Khoroshavina
Tver Regional Clinical Hospital
Russian Federation

170036; 105, Peterburgskoe Sh.; Tver


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I. V. Korobeynikov
0Irkutsk Regional Clinical Hospital, winner of the “Mark of the Honor” award
Russian Federation

664049; 100, Yubileyny Microdistrict; Irkutsk


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O. V. Androphagina
V.D. Seredavin Samara Regional Clinical Hospital
Russian Federation

443095; 159, Tashkentskaya St.; Samara


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N.N. Burdenko Penza Regional Clinical Hospital
Russian Federation

440026; 28, Lermontova St.; Penza


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D. N. Shamalova
Federal Center of Brain and Neurotechnologies, FMBA of Russia
Russian Federation

117997; 1, Ostrovityanova St., Build. 10; Moscow


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N. E. Ermachenko
Krasnodar Regional Clinical Emergency Hospital
Russian Federation

350042; 14, 40-Letiya Pobedy St.; Krasnodar


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V. A. Kutsenko
National Medical Research Center for Therapy and Preventive Medicine, Ministry of Health of Russia
Russian Federation

101000; 10, Petroverigsky Lane; Moscow


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O. E. Ivlev
M.V. Lomonosov Moscow State University; National Medical Research Center for Therapy and Preventive Medicine, Ministry of Health of Russia
Russian Federation

119991; 1, Leninskie Gory; 101000; 10, Petroverigsky Lane; Moscow


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A. G. Soplenkova
M.V. Lomonosov Moscow State University; National Medical Research Center for Therapy and Preventive Medicine, Ministry of Health of Russia
Russian Federation

119991; 1, Leninskie Gory; 101000; 10, Petroverigsky Lane; Moscow


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M. K. Guseva
V.N. Orekhovich Institute of Biomedical Chemistry
Russian Federation

119121; 10, Pogodinskaya St., Build. 8; Moscow


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E. A. Karpova
V.N. Orekhovich Institute of Biomedical Chemistry
Russian Federation

119121; 10, Pogodinskaya St., Build. 8; Moscow


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A. M. Semenov
SuperGene LLC
Russian Federation

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M. P. Semenov
SuperGene LLC
Russian Federation

119270; 6, Luzhnetskaya Nab., Build. 1; Moscow


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I. M. Shirshova
SuperGene LLC
Russian Federation

119270; 6, Luzhnetskaya Nab., Build. 1; Moscow


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S. V. Ivanov
V.N. Orekhovich Institute of Biomedical Chemistry; SuperGene LLC
Russian Federation

119121; 10, Pogodinskaya St., Build. 8; 119270; 6, Luzhnetskaya Nab., Build. 1; Moscow


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Yu. A. Romashova
V.N. Orekhovich Institute of Biomedical Chemistry
Russian Federation

119121; 10, Pogodinskaya St., Build. 8; Moscow


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V. V. Beregovykh
V.N. Orekhovich Institute of Biomedical Chemistry
Russian Federation

119121; 10, Pogodinskaya St., Build. 8; Moscow


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S. S. Markin
V.N. Orekhovich Institute of Biomedical Chemistry; SuperGene LLC
Russian Federation

119121; 10, Pogodinskaya St., Build. 8; 119270; 6, Luzhnetskaya Nab., Build. 1; Moscow


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E. I. Gusev
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of Russia
Russian Federation

117997; 1, Ostrovityanova St.; 1, Ostrovityanova St., Build. 10; Moscow


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For citations:


Shamalov NA, Martynov MY, Marskaya NA, Khasanova DR, Yarovaya EB, Voznuk IA, Timchenko LV, Alasheev AM, Khalo NV, Bogatyreva MD, Khan DS, Korsunskaya LL, Nesterova VN, Chefranova ZY, Kharitonova TV, Sutormin MV, Furman OE, Kulesh AA, Zhukovskaya NV, Khoroshavina KV, Korobeynikov IV, Androphagina OV, Bulanov AA, Shamalova DN, Ermachenko NE, Kutsenko VA, Ivlev OE, Soplenkova AG, Guseva MK, Karpova EA, Semenov AM, Semenov MP, Shirshova IM, Ivanov SV, Romashova YA, Beregovykh VV, Markin SS, Gusev EI. Fortelyzin in the treatment of acute ischemic stroke due to basilar-artery occlusion: data from the observational study FORPI registry. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2026;18(2):36-44. (In Russ.) https://doi.org/10.14412/2074-2711-2026-2-36-44

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