Fortelyzin in the treatment of acute ischemic stroke due to basilar-artery occlusion: data from the observational study FORPI registry
https://doi.org/10.14412/2074-2711-2026-2-36-44
Abstract
The approach to reperfusion therapy for acute ischemic stroke (AIS) in cases of basilar artery occlusion (BAO) remains a matter of debate.
Objective: to assess the safety and efficacy of Fortelyzin in patients with BAO in real-world clinical practice, based on data from the FORPI registry.
Material and methods. The FORPI registry is an open-label, prospective, non-interventional observational study of Fortelyzin in patients with ischaemic stroke. An analysis was conducted of the safety and efficacy of Fortelyzin in a group of patients with basilar artery occlusion who underwent intravenous thrombolytic therapy (IVT) and bridging therapy. The safety endpoint was the incidence of symptomatic intracranial haemorrhage (SICH) as defined by ECASS III and SITS-MOST, as well as all-cause mortality at 90 days. The efficacy endpoint was defined as good functional recovery, defined as a score of 0–2 on the modified Rankin Scale (MRS) at 90 days.
Results. This analysis included 1910 patients who underwent IVT and 53 patients who underwent bridging therapy. The median National Institutes of Health Stroke Scale (NIHSS) scores at admission were 9 and 12 points, respectively (p = 0.01). SICH incidence (ECASS III criteria) was significantly higher in the bridging therapy group compared to IVT group (6 % vs 1 %, p = 0.01). All-cause mortality at day 90 did not differ significantly between the groups (9 % and 7 %, respectively, p = 0.52). Good functional recovery at day 90 was achieved by 69 % of patients in the IVT group and 60 % of patients in the bridging therapy group (p = 0.31).
Conclusion. The use of Fortelyzin in AIS patients with BAO may be considered an effective and safe form of reperfusion therapy, as well as a component of bridging therapy aimed at increasing the number of favorable functional outcomes.
About the Authors
N. A. ShamalovRussian Federation
Nikolay Anatolyevich Shamalov
117997; 1, Ostrovityanova St.; 1, Ostrovityanova St., Build. 10; Moscow
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M. Yu. Martynov
Russian Federation
117997; 1, Ostrovityanova St.; 1, Ostrovityanova St., Build. 10; Moscow
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N. A. Marskaya
Russian Federation
117997; 1, Ostrovityanova St.; Moscow
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D. R. Khasanova
Russian Federation
420012; 49, Butlerova St.; Kazan
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E. B. Yarovaya
Russian Federation
119991; 1, Leninskie Gory; Moscow
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I. A. Voznuk
Russian Federation
197022; 6-8, L'va Tolstogo St.; St. Petersburg
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L. V. Timchenko
Russian Federation
350086; 167, 1 Maya St.; Krasnodar
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A. M. Alasheev
Russian Federation
620102; 185, Volgogradskaya St.; Yekaterinburg
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N. V. Khalo
Russian Federation
660123; 12, Instrumentalnaya St.; Krasnoyarsk
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M. D. Bogatyreva
Russian Federation
355029; 1, Semashko St.; Stavropol
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D. S. Khan
Russian Federation
690091; 57, Aleutskaya St.; Vladivostok
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L. L. Korsunskaya
Russian Federation
295007; 4, Akademika Vernadskogo Prosp.; Simferopol
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V. N. Nesterova
Russian Federation
603093; 190, Rodionova St.; Nizhny Novgorod
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Zh. Yu. Chefranova
Russian Federation
308015; 85, Pobedy St.; Belgorod
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T. V. Kharitonova
Russian Federation
192242; 3, Budapeshtskaya St., lit. A; Saint Petersburg
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M. V. Sutormin
Russian Federation
129110; 61/2, Shchepkina St.; Moscow
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O. E. Furman
Russian Federation
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A. A. Kulesh
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N. V. Zhukovskaya
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K. V. Khoroshavina
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170036; 105, Peterburgskoe Sh.; Tver
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I. V. Korobeynikov
Russian Federation
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D. N. Shamalova
Russian Federation
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O. E. Ivlev
Russian Federation
119991; 1, Leninskie Gory; 101000; 10, Petroverigsky Lane; Moscow
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119270; 6, Luzhnetskaya Nab., Build. 1; Moscow
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I. M. Shirshova
Russian Federation
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S. V. Ivanov
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Yu. A. Romashova
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E. I. Gusev
Russian Federation
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Review
For citations:
Shamalov NA, Martynov MY, Marskaya NA, Khasanova DR, Yarovaya EB, Voznuk IA, Timchenko LV, Alasheev AM, Khalo NV, Bogatyreva MD, Khan DS, Korsunskaya LL, Nesterova VN, Chefranova ZY, Kharitonova TV, Sutormin MV, Furman OE, Kulesh AA, Zhukovskaya NV, Khoroshavina KV, Korobeynikov IV, Androphagina OV, Bulanov AA, Shamalova DN, Ermachenko NE, Kutsenko VA, Ivlev OE, Soplenkova AG, Guseva MK, Karpova EA, Semenov AM, Semenov MP, Shirshova IM, Ivanov SV, Romashova YA, Beregovykh VV, Markin SS, Gusev EI. Fortelyzin in the treatment of acute ischemic stroke due to basilar-artery occlusion: data from the observational study FORPI registry. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2026;18(2):36-44. (In Russ.) https://doi.org/10.14412/2074-2711-2026-2-36-44
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