Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Chronic functional dizziness: rational approaches to diagnosis and treatment in outpatient practice

https://doi.org/10.14412/2074-2711-2025-5-104-112

Abstract

Functional dizziness (FD) is defined as persistent postural perceptual dizziness and is the most common cause of chronic non-rotatory dizziness. In routine clinical practice, there are difficulties and errors in both the diagnosis and treatment of patients with FD. This article presents clinical observations of patients with FD and discusses manifestations, approaches to diagnosis and therapy in outpatient practice. Management of patients with FD should be based on effective communication between the physician and the patient using psychotherapy methods, the creation of an individual treatment strategy that includes vestibular exercises, rehabilitation, and the use of evidence-based pharmacotherapy, with justification of the pathogenetic mechanisms of the leading role of the serotonergic system in neurotransmitter imbalance. Based on the evidence presented in the scientific literature and clinical experience, it is considered appropriate to prescribe Vespireit® to all groups of patients with FD to reduce symptoms of dizziness and instability, restore a sense of balance, and reduce anxiety and vegetative symptoms.

About the Authors

A. L. Guseva
N.I. Pirogov Russian Research Medical University, Ministry of Health of Russia; N.I. Pirogov City Clinical Hospital No.1, Healthcare Department of Moscow
Russian Federation

Acad. B.S. Preobrazhensky Department of Otorhinolaryngology, Faculty of General Medicine

18A, Zagorodnoe Shosse, Build. 2, Moscow 117152,

28, Leninsky Prosp., Moscow 119048


Competing Interests:

The conflict of interests did not affect the results of the study



O. V. Kosivtsova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Russian Federation

Department of Nervous Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine

11, Rossolimo St., Build. 1, Moscow 119021


Competing Interests:

The conflict of interests did not affect the results of the study



V. A. Parfenov
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Russian Federation

Vladimir Anatolyevich Parfenov, Department of Nervous Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine

11, Rossolimo St., Build. 1, Moscow 119021


Competing Interests:

The conflict of interests did not affect the results of the study



References

1. Guseva AL. Vertigo attacks: differential diagnosis and approaches to therapy. Effective Pharmacotherapy. 2021;17(34):16-21. (In Russ.) doi: 10.33978/2307-3586-2021-17-34-16-21

2. Kosivtsova OV, Zamergrad MV. Vertigo in neurological practice (common problems of diagnosis and treatment). Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2012;4(1):48-51. (In Russ.) doi: 10.14412/2074-2711-2012-361

3. Zamergrad MV. Age-Related Aspects of Diagnosis and Treatment of Dizziness: Dis. ... Doct. Med. Sci. Moscow; 2015. (In Russ.)

4. Abdulina OV. Frequency, Causes, Treatment, and Prognosis of Acute Vestibular Dizziness in Emergency Neurology: Dis. ... Cand. Med. Sci. Moscow; 2007. (In Russ.)

5. Makarov SA, Guseva AL. Diagnosis and treatment of dizziness and vertigo in clinical practice. Medical Alphabet. 2023;(21):23-9. (In Russ.) doi: 10.33667/2078-5631-2023-21-23-29

6. Kosivtsova OV, Starchina YuA, Shoev BA. Comorbid disorders and their possible prevention in patients with vestibular vertigo. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2024;16(6):112-7. (In Russ.) doi: 10.14412/2074-2711-2024-6-112-117

7. Samorodskaya IV, Andreev EM, Zaratyants OV, et al. Cerebrovascular disease mortality rates in the population over 50 years of age in Russia and the USA over a 15-year period. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2017;9(2):15-24. (In Russ.) doi: 10.14412/2074-2711-2017-2-15-24

8. Zastenskaya EN, Antonenko LM. Comorbid disorders and therapy of persistent postural perceptual dizziness. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(4):66-73. (In Russ.) doi: 10.14412/2074-2711-2023-466-73

9. Lopez-Gentili LI, Kremenchutzky M, Salgado P. Analisis estadistico de 1.300 pacientes con mareo vertigo. Causas mas frecuentes [A statistical analysis of 1300 patients with dizziness-vertigo. Its most frequent causes]. Rev Neurol. 2003 Mar 1-15;36(5):417-20. (In Spanish)

10. Zamergrad MV, Parfenov VA, Ostroumova OD, et al. Functional dizziness: from diagnostic criteria to clinical profiles and therapy. Expert consensus. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2024;16(4):4-13. (In Russ.) doi: 10.14412/2074-2711-2024-4-4-13

11. Makarov SA. Functional dizziness associated with benign paroxysmal positional vertigo: a prospective clinical and psychological study: Dis. ... Cand. Med. Sci. Moscow; 2022. (In Russ.)

12. Yardley L. Overview of psychologic effects of chronic dizziness and balance disorders. Otolaryngol Clin North Am. 2000 Jun;33(3):603-16. doi: 10.1016/s0030-6665(05)70229-2

13. Lahmann C, Henningsen P, Brandt T, et al. Psychiatric comorbidity and psychosocial impairment among patients with vertigo and dizziness. J Neurol Neurosurg Psychiatry. 2015 Mar;86(3):302-8. doi: 10.1136/jnnp-2014-307601

14. Heinrichs N, Edler C, Eskens S, et al. Predicting continued dizziness after an acute peripheral vestibular disorder. Psychosom Med. 2007 Sep-Oct;69(7):700-7. doi: 10.1097/PSY.0b013e318151a4dd

15. Habs M, Strobl R, Grill E, et al. Primary or secondary chronic functional dizziness: does it make a difference? A DizzyReg study in 356 patients. J Neurol. 2020;267(Suppl 1):212-22. doi: 10.1007/s00415-020-10150-9

16. Bittar RS, Lins EM. Clinical characteristics of patients with persistent postural-perceptual dizziness. Braz J Otorhinolaryngol. 2015 May-Jun;81(3):276-82. doi: 10.1016/j.bjorl.2014.08.012

17. Castro P, Bancroft MJ, Arshad Q, Kaski D. Persistent Postural-Perceptual Dizziness (PPPD) from Brain Imaging to Behaviour and Perception. Brain Sci. 2022 Jun 8;12(6):753. doi: 10.3390/brainsci12060753

18. Li K, Si L, Cui B, et al. Altered intra- and inter-network functional connectivity in patients with persistent postural-perceptual dizziness. Neuroimage Clin. 2020;26:102216. doi: 10.1016/j.nicl.2020.102216

19. Soto E, Vega R, Sesena E. Neuropharmacological basis of vestibular system disorder treatment. J Vestib Res. 2013;23(3):119-37. doi: 10.3233/VES-130494

20. Han L, Wu KL, Kwan PY, et al. 5-HT1A receptor-mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function. J Physiol. 2021 Jan;599(1):253-67. doi: 10.1113/JP282313

21. McCall AA, Miller DM, Yates BJ. Descending Influences on Vestibulospinal and Vestibulosympathetic Reflexes. Front Neurol. 2017 Mar 27;8:112. doi: 10.3389/fneur.2017.00112

22. Dieterich M, Brandt T. Central vestibular networking for sensorimotor control, cognition, and emotion. Curr Opin Neurol. 2024 Feb 1;37(1):74-82. doi: 10.1097/WCO.0000000000001233

23. Staab JP. Chronic subjective dizziness. Continuum (Minneap Minn). 2012 Oct;18(5 Neuro-otology):1118-41. doi: 10.1212/01.CON.0000421622.56525.58

24. Popkirov S, Staab JP, Stone J. Persistent postural-perceptual dizziness (PPPD): a common, characteristic and treatable cause of chronic dizziness. Pract Neurol. 2018 Feb;18(1):5-13. doi: 10.1136/practneurol-2017-001809

25. Bisdorff A, Von Brevern M, Lempert T, Newman-Toker DE. Classification of vestibular symptoms: towards an international classification of vestibular disorders. J Vestib Res. 2009;19(1-2):1-13. doi: 10.3233/VES-2009-0343

26. Bronstein AM. Visual vertigo syndrome: clinical and posturography findings. J Neurol Neurosurg Psychiatry. 1995 Nov;59(5):472-6. doi: 10.1136/jnnp.59.5.472

27. Dyukova GM, Kryukov AI, Makarov SA, et al. A method for prediction functional dizziness after benign paroxysmal positional vertigo. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(5):120-5. (In Russ.) doi: 10.17116/jnevro2021121051120

28. Staab JP, Eckhardt-Henn A, Horii A, et al. Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): Consensus document of the committee for the Classification of Vestibular Disorders of the Barany Society. J Vestib Res. 2017;27(4):191-208. doi: 10.3233/VES-170622

29. Tarnutzer AA, Kerkeni H, Diener S, et al. Diagnosis and treatment of vertigo and dizziness: Interdisciplinary guidance paper for clinical practice. HNO. 2025 Jun 17. (In Engl.) doi: 10.1007/s00106-025-01599-z

30. Pal'chun VT, Guseva AL, Chistov SD, Levina IuV. The otoneurological examination of a patient suffering from dizziness. Russian Bulletin of Otorhinolaryngology. 2015;80(5):60-6. (In Russ.) doi: 10.17116/otorino201580560-66

31. Amelin AV, Lilenko SV, Zamergrad MV, et al. Patient management with complaints of vertigo at the first visit. Russian Medical Inquiry. 2023;7(10):658-65. (In Russ.) doi: 10.32364/2587-6821-2023-7-10-8

32. Helmchen C, Klinkenstein JC, Krüger A, et al. Structural brain changes following peripheral vestibulo-cochlear lesion may indicate multisensory compensation. J Neurol Neurosurg Psychiatry. 2011 Mar;82(3):309-16. doi: 10.1136/jnnp.2010.204925

33. Ivanova GE, Kunelskaya NL, Parfenov VA, et al. Vestibular rehabilitation in complex therapy of vestibular vertigo (consensus of experts). Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2024;16(1):114-21. (In Russ.) doi: 10.14412/2074-2711-2024-1-114-121

34. General characteristics of the medicinal product (GCMP) of Vespirate®, prolongedrelease tablets 15 mg. LP-No. (002822)-(RG-RU). (In Russ.)

35. Zamergrad MV, Parfenov VA, Agafina AS, et al. Efficacy and safety of Vespireit® (buspirone) prolonged-release tablets (PR) 15 mg in the therapy of patients with functional dizziness: results of the double-blind, placebo-controlled, multicenter, randomized, phase 3 clinical trial. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(5):20-34. (In Russ.) doi: 10.14412/2074-2711-2023-5-20-34

36. Loane C, Politis M. Buspirone: what is it all about? Brain Res. 2012 Jun 21;1461:111-8. doi: 10.1016/j.brainres.2012.04.032


Review

For citations:


Guseva AL, Kosivtsova OV, Parfenov VA. Chronic functional dizziness: rational approaches to diagnosis and treatment in outpatient practice. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2025;17(5):104-112. (In Russ.) https://doi.org/10.14412/2074-2711-2025-5-104-112

Views: 15


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)