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Value of determining the cerebrospinal fluid protein markers of amyloidosis and neurodegeneration in the diagnosis of vascular and neurodegenerative cognitive impairments

https://doi.org/10.14412/2074-2711-2013-2450

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Abstract

The article presents data on different forms of moderate cognitive impairments (MCI) and the specific features of their transformation to dementia. Cerebrospinal fluid (CSF) was investigated in 60 patients with the amnestic and neurodynamic types of MCI, in 15 patients with vascular dementia (VD), 50 patients with Alzheimer’s disease (AD), and 23 patients with mixed vascular and neurodegenerative dementia (MVND). The specific features of β-amyloid and τ-protein concentrations were established in the preclinical stages of dementia, which reflects the main components of the pathogenesis of neurodegeneration. In the amnestic form of MCI and AD, there was drastically decreased Aβ-42 and increased τ-protein levels in SCF. As cognitive impairments progressed, there was a rise in the concentration of τ-protein; its level correlated with the severity of dementia. In MND, the level of Aβ-42 was significantly reduced while the concentration of τ-protein was much increased; moreover, to a greater extent than in AD and VD. Cerebrovascular damage and neurodegeneration were related to each other and mutually worsened clinical and pathogenic effects.

About the Authors

Vladimir Yuryevich Lobzin
Department of Nervous System Diseases, S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint-Petersburg
Russian Federation


A Yu Emelin
Department of Nervous System Diseases, S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint-Petersburg


M M Odinak
Department of Nervous System Diseases, S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint-Petersburg


L A Alekseeva
Department of Nervous System Diseases, S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint-Petersburg


N E Monakhova
Department of Nervous System Diseases, S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint-Petersburg


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For citation:


Lobzin V.Y., Emelin A.Y., Odinak M.M., Alekseeva L.A., Monakhova N.E. Value of determining the cerebrospinal fluid protein markers of amyloidosis and neurodegeneration in the diagnosis of vascular and neurodegenerative cognitive impairments. Neurology, Neuropsychiatry, Psychosomatics. 2013;5(4):21-27. (In Russ.) https://doi.org/10.14412/2074-2711-2013-2450

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