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Diabetic peripheral neuropathy therapy-induced activation of humoral serotonin and endogenous neurotrophins

https://doi.org/10.14412/2074-2711-2013-2333

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Abstract

The indicators of pain and psychological status, the concentrations of serum serotonin and blood platelets, and the levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor were studied in 82 patients with diabetic peripheral neuropathy (DPN). Along with conventional treatment aimed to normalize carbohydrate metabolism, 30 patients with DPN received actovegin in an intravenous, jetwise dose of 10.0 ml for 10 days. Prior to treatment, their pain intensity was 5.94±1.2 and 29.6±6.24 scores according to a visual analogue scale (VAS) and PainDETECT, respectively. The subclinical level of anxiety and depression was noted. The amount of serotonin in the serum (90.39±55.43 ng/ml) and blood platelets (298.13±80.33 ng/ml) was lower than that in the control. The content of serum BDNF in DPN was also substantially lower (419.27±132.7 pg/ml; p<0.04) than that in the control. After treatment, the actovegin group showed a more significant reduction in pain syndrome according to the VAS (3.5±0.6 cm; p=0.005) and PainDETECT (19.4±4.1 scores, p=0.005), a decrease in the degree of anxiety and depression according to the Beck inventory (11.4±1.4 scores; p=0.001), and an increase in BDNF levels up to 979.71±289.9 pg/ml. Serum serotonin and blood platelets increased up to 206.13±78.3 and 477.06±114.45 ng/ml, respectively; which is indicative of the correct choice of the treatment for DPN.

About the Authors

Yuulia Vladimirovna Karakulova
Department of Neurology, Prof. V.P. Pervushin Faculty of Therapeutics, Acad. E.A. Vagner Perm State Medical Academy, Ministry of Health of Russia
Russian Federation


N B Kaigorodova
Department of Neurology, Prof. V.P. Pervushin Faculty of Therapeutics, Acad. E.A. Vagner Perm State Medical Academy, Ministry of Health of Russia
Russian Federation


E A Batueva
Department of Neurology, Prof. V.P. Pervushin Faculty of Therapeutics, Acad. E.A. Vagner Perm State Medical Academy, Ministry of Health of Russia
Russian Federation


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For citation:


Karakulova Y.V., Kaigorodova N.B., Batueva E.A. Diabetic peripheral neuropathy therapy-induced activation of humoral serotonin and endogenous neurotrophins. Neurology, Neuropsychiatry, Psychosomatics. 2013;5(3):13-17. (In Russ.) https://doi.org/10.14412/2074-2711-2013-2333

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)