Витамины и другие нутриенты, поддерживающие гомеостаз оксида азота и противодействующие формированию эндотелиопатии

Регуляция уровней оксида азота (NO) в крови – неотъемлемый компонент поддержки цереброваскулярного и сердечно-сосудистого кровотока. На выработку NO в эндотелии сосудов влияют многочисленные факторы, в том числе обеспеченность макро- и микронутриентами. В работе представлены результаты систематизации данных о связях обмена NO с нутриентными факторами. Особое внимание уделено влиянию витаминов группы В (фолаты, витамины В1, В2, В7 и В12) и микробиома на эндотелиальную функцию сосудов, активность NO-синтетазы и предотвращение оксидативно-нитрозативного стресса. Коррекция дефицитов соответствующих витаминов (группы В, А, С, Е, D3), магния и кальция служит важным компонентом профилактики стрессовых состояний и широкого круга заболеваний нервной системы, связанных с эндотелиальной дисфункцией.

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