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Epileptic spasms: Nosological characteristics and approaches to therapy

https://doi.org/10.14412/2074-2711-2013-2484

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Abstract

Objective: to study the incidence, anamnestic, clinical, electroencephalographic, and neuroimaging features of epileptic syndromes associated with epileptic spasms (ES) and the efficiency of antiepileptic therapy in patients with these conditions.
Patients and methods. The study covered 1261 patients with epileptic seizures in the history with their onset from the first day of life to 18 years.
Results. A history of ES was recorded in 112 patients, which accounted for 8.9% of cases among all the forms of epilepsy with its onset less than 18 years of age. ES was detected in 47.1% of the patients with seizure onset in the first year of life. There was a slight male preponderance: 59 (52.7%) versus 53 (47.3%). Epilepsy with ES onset occurred in the first 6 months of life in 57.9% of cases. The West syndrome was found in 58.9% of the patients with ES-associated epilepsy, which amounted to 5.2% of all forms of epilepsy developing at the age of less than 18 years; Ohtahara syndrome in 32.1% (2.9% of all forms of epilepsy), early myoclonic encephalopathy in 0.9% (0.08%) and symptomatic focal epilepsy with periodic spasms in 8.1% (0.7% of all forms of epilepsy). Antiepileptic therapy led to complete remission in 45.5% of ES-associated epilepsy cases. There was a 50% or more reduction in the rate of seizures in 35.7% of the patients treated with antiepileptic drugs. No effect was seen in 18.8% of cases.

About the Authors

M. B. Mironov
St. Luke Institute of Pediatric Neurology and Epilepsy, Moscow
Russian Federation


K. Yu. Mukhin
St. Luke Institute of Pediatric Neurology and Epilepsy, Moscow
Russian Federation


References

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For citation:


Mironov M.B., Mukhin K.Yu. Epileptic spasms: Nosological characteristics and approaches to therapy. Neurology, Neuropsychiatry, Psychosomatics. 2013;5(1S):23-28. (In Russ.) https://doi.org/10.14412/2074-2711-2013-2484

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ISSN 2074-2711 (Print)
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