SSRI-associated apathy in Alzheimer's disease: a case series
https://doi.org/10.14412/2074-2711-2022-4-51-53
Abstract
Apathy is one of the most common manifestations of neurodegenerative pathology, including Alzheimer's disease (AD). Despite such a significant role of apathy in the course of the disease, there are no unambiguous recommendations for the treatment and prevention of this symptom complex. Some classes of psychotropic drugs commonly prescribed for AD, such as antidepressants of the SSRI class, may themselves cause apathy. The authors present a series of clinical observations describing four cases of deterioration in the condition of patients with AD during SSRI therapy. The features of the clinical course of the disease are discussed, new strategies for drug therapy are proposed.
About the Authors
D. S. Petelin
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
Dmitry Sergeevich Petelin
119991, Moscow, Bolshaya Pirogovskaya St., 2, Build. 4
Competing Interests:
There are no conflicts of interest.
A. N. Gamirova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
119991, Moscow, Bolshaya Pirogovskaya St., 2, Build. 4
Competing Interests:
There are no conflicts of interest.
O. N. Voskresenskaya
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
119991, Moscow, Bolshaya Pirogovskaya St., 2, Build. 4
Competing Interests:
There are no conflicts of interest.
B. A. Volel
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
119991, Moscow, Bolshaya Pirogovskaya St., 2, Build. 4
Competing Interests:
There are no conflicts of interest.
References
1. Sofi F, Marcucci R, Gori AM, et al. Residual platelet reactivity on aspirin therapy and recurrent cardiovascular events – a meta-analysis. Int J Cardiol. 2008 Aug 18;128(2):166-71. doi:10.1016/j.ijcard.2007.12.010. Epub 2008 Feb 1.
2. Ishii S, Weintraub N, Mervis JR. Apathy: a common psychiatric syndrome in the elderly. J Am Med Dir Assoc. 2009 Jul;10(6):381-93. doi:10.1016/j.jamda.2009.03.007
3. Barnhart WJ, Makela EH, Latocha MJ. SSRI-induced apathy syndrome: a clinical review. J Psychiatr Pract. 2004 May;10(3):196-9. doi:10.1097/00131746-200405000-00010
4. Pan X, Kaminga AC, Wen SW, et al. Dopamine and Dopamine Receptors in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis. Front Aging Neurosci. 2019 Jul 11;11:175. doi:10.3389/fnagi.2019.00175
5. Sansone RA, Sansone LA. SSRI-Induced Indifference. Psychiatry (Edgmont). 2010 Oct;7(10):14-8.
Review
For citations:
Petelin DS, Gamirova AN, Voskresenskaya ON, Volel BA. SSRI-associated apathy in Alzheimer's disease: a case series. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2022;14(4):51-53. (In Russ.) https://doi.org/10.14412/2074-2711-2022-4-51-53
Views:
615
Email this article 