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Anxiety-depressive spectrum disorders in cervical dystonia

https://doi.org/10.14412/2074-2711-2022-4-38-43

Abstract

A decrease in the quality of life (QoL) in cervical dystonia (CD) is often due to anxiety and depressive manifestations. However, the change in the emotional state of patients with CD after botulinum therapy has not been studied enough.
Objective: a comparative analysis of the severity of anxiety and depressive disorders in CD and their dynamics during the year with a decrease in movement disorders during botulinum therapy.
Patients and methods. 25 patients with CD (9 men and 16 women) and 25 healthy volunteers (11 men and 14 women) were examined. The severity of CD was assessed using the Tsui Rating Scale. To assess the level of anxiety, the GAD-7 scales were used, depression – PHQ-9. The EQ-5D questionnaire was used to assess the quality of life. The emotional state was assessed before and after 4, 8 and 12 months of the correction of movement disorders using botulinum therapy. The control group was examined at similar time intervals.
Results and discussion. Patients with CD have a significant increase in anxiety (13.5±3.6) and depression (7.72±5.2), as well as a decrease in QoL (66.6±11.0) compared with the control group (p<0.001). Anxiety symptoms show a significant dependence on the clinical severity of CD symptoms and regress against the background of successful botulinum therapy – from 13.50±3.6 at the time of the first visit to 8.20±2.9 (p<0.001) by the fourth visit. Depressive symptoms do not depend on the motor manifestations of CD and do not improve as a result of successful botulinum therapy, tending to increase from 7.72±5.2 to 10.12±5.8 (p<0.05).
Conclusion. The persistence of depression after successful botulinum therapy in CD indicates its role as an emotional manifestation of the disease independent of motor disorders.

About the Authors

V. A. Tolmacheva
Department of Nervous Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Violetta Aleksandrovna Tolmacheva
119021, Moscow, Rossolimo St., 11, Build. 1


Competing Interests:

There are no conflicts of interest.



P. G. Yuzbashyan
Department of Psychiatry and Psychosomatics, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

115522, Moscow, Kashirskoe Sh., 34


Competing Interests:

There are no conflicts of interest.



D. S. Petelin
Department of Psychiatry and Psychosomatics, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

115522, Moscow, Kashirskoe Sh., 34


Competing Interests:

There are no conflicts of interest.



B. A. Volel
Department of Psychiatry and Psychosomatics, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Mental Health Research Center
Russian Federation

115522, Moscow, Kashirskoe Sh., 34


Competing Interests:

There are no conflicts of interest.



N. I. Salouhina
Institute of Experimental Medicine
Russian Federation

197376, Saint Petersburg, Academika Pavlova St., 12


Competing Interests:

There are no conflicts of interest.



M. R. Nodel
Department of Nervous Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

119021, Moscow, Rossolimo St., 11, Build. 1


Competing Interests:

There are no conflicts of interest.



D. V. Romanov
Department of Psychiatry and Psychosomatics, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Mental Health Research Center
Russian Federation

115522, Moscow, Kashirskoe Sh., 34


Competing Interests:

There are no conflicts of interest.



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For citations:


Tolmacheva VA, Yuzbashyan PG, Petelin DS, Volel BA, Salouhina NI, Nodel MR, Romanov DV. Anxiety-depressive spectrum disorders in cervical dystonia. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2022;14(4):38-43. (In Russ.) https://doi.org/10.14412/2074-2711-2022-4-38-43

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ISSN 2074-2711 (Print)
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