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Biological basis of aggressive behavior

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This scientific review highlights the results of domestic and foreign studies aimed at researching the biological aspects of failure to control aggressive impulses. We analyze the role of serotonergic, dopaminergic, noradrenergic, glutamatergic systems, and neuroendocrine mechanisms in aggression manifestation. We discuss the inconsistency of modern concepts about the neurochemical nature of aggressive behavior. The relevance of evaluating the biomarkers of public danger is substantiated. Finally, questions of psychopharmacotherapy of aggressive behavior are reviewed. 

About the Authors

O. A. Makushkina
V.P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of Russia
Russian Federation

23, Kropotkinskiy per., Moscow 119034

O. I. Gurina
V.P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of Russia
Russian Federation

23, Kropotkinskiy per., Moscow 119034

V. A. Golenkova
V.P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of Russia
Russian Federation

23, Kropotkinskiy per., Moscow 119034


1. Brown GL, Goodwin FK, Ballenger JC, et al. Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res. 1979 Oct;1(2):131-9. doi: 10.1016/0165-1781(79)90053-2

2. Duke AA, Bеgue L, Bell R, Eisenlohr-Moul T. Revisiting the serotoninaggression relation in humans: a meta-analysis. Psychol Bull. 2013 Sep;139(5):1148-72. doi: 10.1037/a0031544. Epub 2013 Feb 4.

3. Moller SE, Mortensen EL, Breum L, et al. Aggression and personality: association with amino acids and monoamine metabolites. Psychol Med. 1996 Mar;26(2):323-31. doi: 10.1017/s0033291700034711

4. Prochazka H, Agren H. Self-rated aggression and cerebral monoaminergic turnover. Sex differences in patients with persistent depressive disorder. Eur Arch Psychiatry Clin Neurosci. 2003 Aug;253(4):185-92. doi: 10.1007/s00406-003-0423-8

5. Kogan BM, Drozdov AZ. Pathogenetic mechanisms in the development of depressive disorders. Sistemnaya psikhologiya i sotsiologiya. 2013;(7):46-50 (In Russ.).

6. Coccaro EF, Lee R. Cerebrospinal fluid 5- hydroxyindolacetic acid and homovanillic acid: reciprocal relationships with impulsive aggression in human subjects. J Neural Transm (Vienna). 2010 Feb;117(2):241-8. doi: 10.1007/s00702-009-0359-x

7. Soderstrom H, Blennow K, Manhem A, Forsman A. CSF studies in violent offenders. I. 5-HIAA as a negative and HVA as a positive predictor of psychopathy. J Neural Transm (Vienna). 2001;108(7):869-78. doi: 10.1007/s007020170036

8. Coccaro EF, Fanning JR, Phan KL, et al. Serotonin and impulsive aggression. CNS Spectr. 2015 Jun;20(3):295-302. doi: 10.1017/S1092852915000310

9. Hagenbeek FA, Kluft C, Hankemeier T, et al. Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry. Am J Med Genet B Neuropsychiatr Genet. 2016 Jul;171(5):719-32. doi: 10.1002/ajmg.b.32435. Epub 2016 Feb 23.

10. Comai S, Bertazzo A, Vachon J, et al. Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: markers for aggression. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Oct 3;70:8-16. doi: 10.1016/j.pnpbp.2016.04.012. Epub 2016 Apr 23.

11. Tiihonen J, Virkkunen M, Rasanen P, et al. Free L-tryptophan plasma levels in antisocial violent offenders. Psychopharmacology (Berl). 2001 Oct;157(4):395-400. doi: 10.1007/s002130100842

12. Soderstrom H, Blennow K, Forsman A, et al. A controlled study of tryptophan and cortisol in violent offenders. J Neural Transm (Vienna). 2004 Dec;111(12):1605-10. doi: 10.1007/s00702-004-0219-7

13. Manchia M, Comai S, Pinna M, et al. Biomarkers in aggression. Adv Clin Chem. 2019;93:169-237. doi: 10.1016/bs.acc.2019.07.004. Epub 2019 Sep 11.

14. Narvaes R, Martins de Almeida RM. Aggressive behavior and three neurotransmitters: dopamine, GABA, and serotonin – A review of the last 10 years. Psychol Neurosci. 2014 Jun;7(4):601-7. doi: 10.3922/j.psns.2014.4.20

15. Rosell DR, Siever LJ. The neurobiology of aggression and violence. CNS Spectr. 2015 Jun;20(3):254-79. doi: 10.1017/S109285291500019X. Epub 2015 May 4.

16. Giotakos O, Markianos M, Vaidakis N, et al. Aggression, impulsivity, plasma sex hormones, and biogenic amine turnover in a forensic population of rapists. J Sex Marital Ther. May-Jun 2003;29(3):215-25. doi: 10.1080/00926230390155113

17. Ramirez-Bermudez J, Perez-Neri I, Montes S, et al. Imbalance between nitric oxide and dopamine may underly aggression in acute neurological patients. Neurochem Res. 2010 Oct;35(10):1659-65. doi: 10.1007/s11064-010-0227-y. Epub 2010 Aug 1.

18. Daderman AM, Lidberg L. Relapse in violent crime in relation to cerebrospinal fluid monoamine metabolites (5-HIAA, HVA and HMPG) in male forensic psychiatric patients convicted of murder: a 16-year followup. Acta Psychiatr Scand. 2002;(412):71-4. doi: 10.1034/j.1600-0447.106.s412.16.x

19. Terbeck S, Savulescu J, Chesterman LP, Cowen PJ. Noradrenaline effects on social behavior, intergroup relations, and moral decisions. Neurosci Biobehav Rev. 2016 Jul;66:54- 60. doi: 10.1016/j.neubiorev.2016.03.031. Epub 2016 Apr 25.

20. Comai S, Tau M, Gobbi G. The psychopharmacology of aggressive behavior: a translational approach: part 1: neurobiology. J Clin Psychopharmacol. 2012 Feb;32(1):83-94. doi: 10.1097/JCP.0b013e31823f8770

21. Cheng J, Xiong Z, Duffney LJ, et al. Methylphenidate exerts dose-dependent effects on glutamate receptors and behaviors. Biol Psychiatry. 2014 Dec 15;76(12):953-62. doi: 10.1016/j.biopsych.2014.04.003. Epub 2014 Apr 12.

22. Coccaro EF, Lee R, McCloskey M. Norepinephrine Function in Personality Disorder: Plasma Free MHPG Correlates Inversely with Life History of Aggression. CNS Spectr. 2003 Oct;8(10):731-6. doi: 10.1017/s1092852900019106 23. Chichinadze KN, Domianidze TR, Matitaishvili TTs, et al. Possible relation of plasma testosterone level to aggressive behavior of male prisoners. Bull Exp Biol Med. 2010 Jul;149(1):7-9. doi: 10.1007/s10517-010-0861-z

23. Miczek KA, DeBold JF, Gobrogge K, et al. The Role of Neurotransmitters in Violence and Aggression. In: Sturmey P, editor. The Wiley Handbook of Violence and Aggression. New York; 2017. P. 1-13. doi: 10.1002/9781119057574.whbva019

24. Gulsun M, Oznur T, Aydemir E, et al. Possible relationship between amino acids, aggression and psychopathy. Int J Psychiatry Clin Pract. 2016;20(2):91-100. doi: 10.3109/13651501.2016.1144771. Epub 2016 Mar 16.

25. Kibitov AO, Kuznetsova MN. Molecular mechanism of alcohol addiction: the role of glutamate receptors of the brain. Voprosy narkologii. 2019;5(176):58-98. doi: 10.47877/0234-0623_2019_5_58 (In Russ.).

26. Coccaro EF, Lee R, Vezina P. Cerebrospinal fluid glutamate concentration correlates with impulsive aggression in human subjects. J Psychiatr Res. 2013 Sep;47(9):1247-53. doi: 10.1016/j.jpsychires.2013.05.001. Epub 2013 Jun 18.

27. Bjork JM, Moeller FG, Kramer GL, et al. GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder. Psychiatry Res. 2001 Mar 25;101(2):131-6. doi: 10.1016/s0165-1781(01)00220-7

28. Lee R, Petty F, Coccaro EF. Cerebrospinal fluid GABA concentration: relationship with impulsivity and history of suicidal behavior, but not aggression, in human subjects. J Psychiatr Res. 2009 Jan;43(4):353-9. doi: 10.1016/j.jpsychires.2008.04.004. Epub 2008 May 19.

29. Miczek KA, Fish EW, De Bold JF. Neurosteroids, GABAA receptors, and escalated aggressive behavior. Horm Behav. 2003 Sep;44(3):242-57. doi: 10.1016/j.yhbeh.2003.04.002

30. Yu YZ, Shi JX. Relationship between levels of testosterone and cortisol in saliva and aggressive behaviors of adolescents. Biomed Environ Sci. 2009 Feb;22(1):44-9. doi: 10.1016/S0895-3988(09)60021-0

31. Horn M, Potvin S, Allaire JF, et al. Male inmate profiles and their biological correlates. Can J Psychiatry. 2014 Aug;59(8):441-9. doi: 10.1177/070674371405900807

32. Pajer K, Tabbah R, Gardner W, et al. Adrenal androgen and gonadal hormone levels in adolescent girls with conduct disorder. Psychoneuroendocrinology. 2006 Nov;31(10):1245- 56. doi: 10.1016/j.psyneuen.2006.09.005

33. Maras A, Laucht M, Gerdes D, et al. Association of testosterone and dihydrotestosterone with externalizing behavior in adolescent boys and girls. Psychoneuroendocrinology. 2003 Oct;28(7):932-40. doi: 10.1016/s0306-4530(02)00119-1

34. Dmitrieva TN, Oades RD, Hauffa BP, Eggers C. Dehydroepiandrosterone sulphate and corticotropin levels are high in young male patients with conduct disorder: comparisons for growth factors, thyroid and gonadal hormones. Neuropsychobiology. 2001;43(3):134-40. doi: 10.1159/000054881

35. Archer J, Graham-Kevan N, Davies M. Testosterone and aggression: A reanalysis of Book, Starzyk, and Quinsey's (2001) study. Aggress Violent Behav. 2005 Feb;10(2):241-61. doi: 10.1016/j.avb.2004.01.001

36. Uzbekov MG, Maksimova NM, Brilliantova VV, et al. On the issue of biological markers of efficiency of therapy of mental and neurological diseases. Sibirskiy vestnik psikhiatrii i narkologii. 2018;2(99):5-14. doi: 10.26617/1810-3111- 2018-2(99)-5-14 (In Russ.).

37. Terburg D, Morgan B, van Honk J. The testosterone-cortisol ratio: A hormonal marker for proneness to social aggression. Int J Law Psychiatry. Jul-Aug 2009;32(4):216-23. doi: 10.1016/j.ijlp.2009.04.008. Epub 2009 May 15.

38. Montoya ER, Terburg D, Bos PA, van Honk J. Testosterone, cortisol, and serotonin as key regulators of social aggression: A review and theoretical perspective. Motiv Emot. 2012 Mar;36(1):65-73. doi: 10.1007/s11031-011-9264-3. Epub 2011 Nov 25.

39. Lane SD, Kjome KL, Moeller FG. Neuropsychiatry of aggression. Neurol Clin. 2011 Feb;29(1):49-64, vii. doi: 10.1016/j.ncl.2010.10.006

40. Frogley C, Taylor D, Dickens G, Picchioni M. A systematic review of the evidence of clozapine's anti-aggressive effects. Int J Neuropsychopharmacol. 2012 Oct;15(9):1351- 71. doi: 10.1017/S146114571100201X. Epub 2012 Feb 20.

41. Siegel A, Bhatt S, Bhatt R, Zalcman SS. The neurobiological bases for development of pharmacological treatments of aggressive disorders. Curr Neuropharmacol. 2007;5(2):135- 47. doi: 10.2174/157015907780866929

42. Trifu SC, Tudor A, Radulescu I. Aggressive behavior in psychiatric patients in relation to hormonal imbalance (Review). Exp Ther Med. 2020 Oct;20(4):3483-7. doi: 10.3892/etm.2020.8974. Epub 2020 Jul 7.

43. Makushkina OA, Gurina OI, Vyatkina AI. Study of serotonin, dopamine and hormone profile indicators in individuals with mental disorders with aggressive illegal behavior. Rossiyskiy psikhiatricheskiy zhurnal = Russian Journal of Psychiatry. 2020;(2):46-54. doi: 10.24411/1560-957X-2020-10206 (In Russ.).


For citations:

Makushkina O.A., Gurina O.I., Golenkova V.A. Biological basis of aggressive behavior. Neurology, Neuropsychiatry, Psychosomatics. 2022;14(1):76-81. (In Russ.)

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)