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Association of polymorphic marker Val158Met of COMT gene with depression in an open population 25–44 years old (WHO international program MONICA, epidemiological study)

https://doi.org/10.14412/2074-2711-2021-2-19-25

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Abstract

Objective: to investigate the association of the polymorphic marker Val158Met in the catechol-O-methyl transferase (COMT) gene with depression in an open population aged 25–44 years.

Patients and methods. A representative sample of the  population living in Oktjabr'skij district of Novosibirsk aged 25– 44 years (427 men, median age – 34±0.4 years, response rate –  71%; 548 women, median age 35±0.4 years, response rate –  72%) was screened in 2013–2016 (budget framework № 0324- 2018-0001, Reg. № AAAA-A17-117112850280-2). In addition to  the standard epidemiological examination, screening participants underwent psychological testing, which determined  the level of depression. Study participants who  underwent COMT Val158Met (rs4680) polymorphism genotyping were randomly assigned to a cohort of 224 men  and 217 women. Pearson's χ2 test was used to test the  statistical significance of differences between these groups;  p≤0.05 was considered statistically significant in all types of  analysis.

 Results and discussion. In an open population aged 25–44 years, the prevalence of severe depression (SD) was 13.2%,  moderate depression – 24.4%. SD was more prevalent in COMT G/G genotype carriers (61.8%), compared to A/A genotype carriers (38.2%; χ2=6.097; df=2, p=0.047); the G allele carriers  also had a higher prevalence of SD (55.3%), compared to A  allele carries (44.7%; χ2=5.408; df=1; p=0.02).  SD was less prevalent among male COMT A/A genotype carriers (15.8%), compared to G/A genotype carriers (84.2%; χ2=4.603; df=1; p=0.032). SD was more prevalent in female G/G genotype  carriers (65.5%), compared to A/A genotype carriers (34.5%;  χ2=4.769; df=1; p=0.029). The G allele was more common among women with SD (58.2%) than the A allele (41.8%;  χ2=6.658; df=2; p=0.01). In a logistic regression model, COMT Val/Val genotype in the studied population [Relative risk (RR) 1.594], as well as G (Val) allele in the studied population  (RR=1.378) and women (RR=1.557), significantly increased the  risk of depression. 

Conclusion. The data allows us to assume that COMT G/G  polymorphism may be linked to a high depression level.  

About the Authors

V. V. Gafarov
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center «Research Institute of Cytology and Genetics» Siberian Branch, Russian Academy of Sciences; Collaborative Laboratory of Cardiovascular Diseases Epidemiology
Russian Federation

 175/1, Boris Bogatkov St., Novosibirsk 630089, Russia 



E. A. Gromova
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center «Research Institute of Cytology and Genetics» Siberian Branch, Russian Academy of Sciences; Collaborative Laboratory of Cardiovascular Diseases Epidemiology
Russian Federation

 175/1, Boris Bogatkov St., Novosibirsk 630089, Russia 



D. O. Panov
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center «Research Institute of Cytology and Genetics» Siberian Branch, Russian Academy of Sciences; Collaborative Laboratory of Cardiovascular Diseases Epidemiology
Russian Federation

 175/1, Boris Bogatkov St., Novosibirsk 630089, Russia 



V. N. Maksimov
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center «Research Institute of Cytology and Genetics» Siberian Branch, Russian Academy of Sciences
Russian Federation

 175/1, Boris Bogatkov St., Novosibirsk 630089, Russia 



I. V. Gagulin
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center «Research Institute of Cytology and Genetics» Siberian Branch, Russian Academy of Sciences; Collaborative Laboratory of Cardiovascular Diseases Epidemiology
Russian Federation

 175/1, Boris Bogatkov St., Novosibirsk 630089, Russia 



A. V. Gafarova
Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center «Research Institute of Cytology and Genetics» Siberian Branch, Russian Academy of Sciences; Collaborative Laboratory of Cardiovascular Diseases Epidemiology
Russian Federation

 175/1, Boris Bogatkov St., Novosibirsk 630089, Russia 



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For citation:


Gafarov V.V., Gromova E.A., Panov D.O., Maksimov V.N., Gagulin I.V., Gafarova A.V. Association of polymorphic marker Val158Met of COMT gene with depression in an open population 25–44 years old (WHO international program MONICA, epidemiological study). Neurology, Neuropsychiatry, Psychosomatics. 2021;13(2):19-25. https://doi.org/10.14412/2074-2711-2021-2-19-25

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