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Tolperisone in the treatment of acute and chronic nonspecific back pain

https://doi.org/10.14412/2074-2711-2020-4-137-142

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Abstract

Nonspecific back pain (NBP) is one of the most common reasons to see a neurologist or therapist. Acute (<4 weeks' duration), subacute (4 to 12 weeks), and chronic (>12 weeks) NBPs are recognized. The diagnosis of NBP is based on anamnestic data, somatic, neurological, and neurologic-and-orthopedic examination findings and on the exclusion of the specific causes of back pain, discogenic radiculopathy, and vertebral canal stenosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants are used in the pharmacotherapy of acute, subacute, and chronic NBP. Tolperisone is widely used as a muscle relaxant in Russia and in the countries of Europe and Asia. Clinical trials have shown the efficacy and good tolerance of tolperisone used alone and in combination with NSAIDs for NBP. The review presents clinical recommendations from different countries on the use of muscle relaxants in the treatment of acute and chronic NBP. It is concluded that a large-scale qualitative randomized trial should be conducted to investigate the efficacy of muscle relaxants, tolperisone in particular, in the treatment of acute, subacute, and chronic NBP.

About the Authors

V. A. Golovacheva
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Veronika Aleksandrovna Golovacheva

Department of Nervous System Diseases and Neurosurgery, Institute of Clinical Medicine

11, Rossolimo St., Build. 1, Moscow 119021



A. A. Golovacheva
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Department of Nervous System Diseases and Neurosurgery, Institute of Clinical Medicine

11, Rossolimo St., Build. 1, Moscow 119021



O. E. Zinovyeva
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Department of Nervous System Diseases and Neurosurgery, Institute of Clinical Medicine

11, Rossolimo St., Build. 1, Moscow 119021



V. L. Golubev
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation

Department of Nervous System Diseases, Institute of Professional Education

86, Shosse Entuziastov, Moscow 1111223



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For citation:


Golovacheva V.A., Golovacheva A.A., Zinovyeva O.E., Golubev V.L. Tolperisone in the treatment of acute and chronic nonspecific back pain. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(4):137-142. (In Russ.) https://doi.org/10.14412/2074-2711-2020-4-137-142

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)