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Investigation of the anticonvulsant and remyelinating potential of dexketoprofen on a rat model of primary generalized seizures

https://doi.org/10.14412/2074-2711-2020-4-84-90

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Abstract

Objective: to investigate the effect of dexketoprofen on the severity of seizures on a rat model of primary generalized seizures caused by thiosemicarbazide; to evaluate the neuroprotective effect of the drug.

Material and methods. The investigation was conducted on 72 male albino rats weighing 200–300 g. The animals were given dexketoprofen and/or comparison drugs (gabapentin, sodium valproate) for 5 days, after which the seizure model was reproduced. The effects of the drugs were evaluated from a set of neurological tests and the results of a histopathological examination of the brain.

Results and discussion. Dexketoprofen reduced the severity, duration, and number of primary generalized seizures and potentiated the anticonvulsant effects of gabapentin and sodium valproate. Histopathological and morphometric examinations of the rat brain showed that dexketoprofen inhibited the formation of irreversible neuronal changes (27.2%; control, 55.7%), by transferring them into reversible changes (47.7%; control, 21.8%).

Conclusion. The investigation made it possible to conclude that dexketoprofen had a moderate neuroprotective effect neurologically and morphometrically verified.

About the Authors

O. A. Gromova
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Center for Big Data Storage and Analysis, National Center for Digital Economy, M.V. Lomonosov Moscow State University
Russian Federation

Olga Alekseevna Gromova

44, Vavilov St., Build. 2, Moscow 119333
27, Lomonosovsky Prospect, Build. 1, Moscow 117997 



V. I. Demidov
Ivanovo State Medical Academy, Ministry of Health of Russia
Russian Federation
8, Sheremetevsky Prosp., Ivanovo 153012


A. G. Kalacheva
Ivanovo State Medical Academy, Ministry of Health of Russia
Russian Federation
8, Sheremetevsky Prosp., Ivanovo 153012


I. Yu. Torshin
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Center for Big Data Storage and Analysis, National Center for Digital Economy, M.V. Lomonosov Moscow State University
Russian Federation
44, Vavilov St., Build. 2, Moscow 119333
27, Lomonosovsky Prospect, Build. 1, Moscow 117997


T. R. Grishina
Ivanovo State Medical Academy, Ministry of Health of Russia
Russian Federation
8, Sheremetevsky Prosp., Ivanovo 153012


T. E. Bogacheva
Ivanovo State Medical Academy, Ministry of Health of Russia
Russian Federation
8, Sheremetevsky Prosp., Ivanovo 153012


References

1. Dydyk AM, Givler A. Central Pain Syndrome. 2020 Apr 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan. PMID: 31971703.

2. Vuilleumier PH, Schliessbach J, Curatolo M. Current evidence for central analgesic effects of NSAIDs: an overview of the literature. Minerva Anestesiol. 2018 Jul;84(7):865-70. doi: 10.23736/S0375-9393.18.12607-1. Epub 2018 May 9.

3. Veltmeijer MTW, Veeneman D, Bongers CCCW, et al. The impact of central and peripheral cyclooxygenase enzyme inhibition on exercise-induced elevations in core body temperature. Int J Sports Physiol Perform. 2017 May;12(5):662-7. doi: 10.1123/ijspp.20160382. Epub 2016 Sep 26.

4. Auriel E, Regev K, Korczyn AD. Nonsteroidal anti-inflammatory drugs exposure and the central nervous system. Handb Clin Neurol. 2014;119:577-84. doi: 10.1016/B978-07020-4086-3.00038-2

5. Balashov AM, Shakhbazyan IE. Central mechanisms of analgesic action of non-steroidal antiinflammatory drugs. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2005;43(2):47-53 (In Russ.).

6. Torshin IYu, Gromova OA, Stakhovskaya LV, et al. Differential chemoreactome analysis of synergistic combinations of tolperisone and nonsteroidal anti-inflammatory drugs. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2019;11(2):78-85. doi: 10.14412/2074-27112019-2-78-85 (In Russ.)].

7. Torshin IYu. Optimal dictionaries output information based on the criterion of Solvability and their applications in Bioinformatics. Pattern Recognit Image Anal. 2013;23(2):319-27. doi: 10.1134/S1054661813020156

8. Torshin IYu, Rudakov KV. On the application of the combinatorial theory of solvability to the analysis of chemographs. Part 1: Fundamentals of modern chemical bonding theory and the concept of the chemograph. Pattern Recognit Image Anal. 2014;24(1):11-23. doi: 10.1134/S1054661814010209

9. Torshin IYu, Rudakov KV. On the application of the combinatorial theory of solvability to the analysis of chemographs. Part 2: Local completeness of invariants of chemographs in view of the combinatorial theory of solvability. Pattern Recognit Image Anal. 2014;24(2):196-208. doi: 10.1134/S1054661814020151

10. Gromova OA, Torshin IYu, Putilina MV, et al. Chemoreactom analysis of central mechanisms of non-steroidal anti-inflammatory drugs. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2020;120(1):70-7. doi: 10.17116/jnevro202012001170 (In Russ.).

11. Torshin IYu, Gromova OA, Fedotova LE, Gromov AN. Comparative chemoreactome analysis of dexketoprofen, ketoprofen and diclofenac. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):47-54. doi: 10.14412/2074-2711-2018-1-47-54 (In Russ.).

12. Gromova OA, Kalacheva AG, Grishina TR, et al. Modulating the effect of anticonvulsants with micronutrients in the experiment. RMJ. 2016;24(13):874-8 (In Russ.).

13. Gromova OA, Kalacheva AG, Grishina TR, et al. Neurotrophic peptides of cerebrolysin as a basis for anticonvulsant effect of the drug. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116(3):55-62 (In Russ.).

14. Kalacheva AG, Bogacheva TE, Gromova OA, et al. Study of the effects of magnesium orotate on a model of primary generalized seizures in rats. Farmakokinetika i farmakodinamika = Pharmacokinetics and Pharmacodynamics. 2017;(4):7-11 (In Russ.).

15. Kalacheva AG, Gromova OA, Grishina TR, et al. An experimental study of anticonvulsant effects of myo-inositol and folic acid. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116(9)56-61. doi: 10.17116/jnevro20161169156-61 (In Russ.).

16. Mironov AN, editor. Rukovodstvo po provedeniy doklinicteskih issledovanyi lekarstvennih sredstv [Guidelines for preclinical studies of drugs]. Part one. Moscow: Grif and K; 2013. P. 235-50 (In Russ.).


For citation:


Gromova O.A., Demidov V.I., Kalacheva A.G., Torshin I.Yu., Grishina T.R., Bogacheva T.E. Investigation of the anticonvulsant and remyelinating potential of dexketoprofen on a rat model of primary generalized seizures. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(4):84-90. (In Russ.) https://doi.org/10.14412/2074-2711-2020-4-84-90

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)