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The characteristics of chronic inflammatory demyelinating polyneuropathy in patients with diabetes mellitus

https://doi.org/10.14412/2074-2711-2020-3-24-29

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Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) in patients with diabetes mellitus (DM) occurs approximately 9—11 times more frequently than in the general population.

Objective: to assess the characteristics of CIDP in the presence of DM.

Patients and methods. A total of 109 patients with CIDP diagnosed according to the international EFNS/PNS criteria were examined. Seventeen patients had type 1 or 2 DM; the remaining 92 patients did not.

Results and discussion. The patients with CIDP and DM were found to have significantly more obvious neurological deficit, lower levels of selfservice, and a shorter time to diagnose CIDP than those with CIDP without DM.

The concurrence of CIDP and DM is ambiguously assessed. On the one hand, there are indications of a strict correlation between these conditions, and on the other, the absence of this association. Our study showed that more obvious neurological deficit in DM can be related to the additional damaging impact of chronic hyperglycemia as impaired metabolism of nerve fibers and deterioration of their trophism. The autoimmune nerve damage occurring in CIDP is superimposed on the already existing impairments in the microcirculation and dysfunction of peripheral nerves, thereby increasing their damage.

Conclusion. The course of CIDP in the presence of DM differs from that of «pure» CIDP, which should be taken into account in managing these patients.

About the Authors

R. A. Gapeshin
Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation

6—8, Lev Tolstoy St., Saint Petersburg 197022.



E. R. Barantsevich
Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation

6—8, Lev Tolstoy St., Saint Petersburg 197022.



D. I. Rudenko
Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia; City Multidisciplinary Hospital Two
Russian Federation

6—8, Lev Tolstoy St., Saint Petersburg 197022; 5, Uchebnyi Lane, M. Ozerki, Saint Petersburg 194354.



T. R. Stuchevskaya
Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia; City Multidisciplinary Hospital Two
Russian Federation

6—8, Lev Tolstoy St., Saint Petersburg 197022; 5, Uchebnyi Lane, M. Ozerki, Saint Petersburg 194354.



A. A. Yakovlev
Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Russian Federation

6—8, Lev Tolstoy St., Saint Petersburg 197022; 41, Kirochnaya St., Saint Petersburg 191015.



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For citation:


Gapeshin R.A., Barantsevich E.R., Rudenko D.I., Stuchevskaya T.R., Yakovlev A.A. The characteristics of chronic inflammatory demyelinating polyneuropathy in patients with diabetes mellitus. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(3):24-29. (In Russ.) https://doi.org/10.14412/2074-2711-2020-3-24-29

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)