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Прогностическая значимость умеренных когнитивных нарушений у пациентов с высоким и очень высоким кардиоваскулярным риском

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Abstract

Aim. To assess the prognostic significance of cognitive impairments detected using the MMSE scale in patients at high and very high cardiovascular risk (CVR).

Patients and methods. The study included men and women aged 40-75 years at high and very high CVR, determined in accordance with the recommendations of the European Society of Cardiology on cardiovascular prevention in 2016. The study included 111 patients at high and very high CVR. High CVR was established in 30 (27,0%) patients. Very high CVR was established in 81 (73,0%) patients. The median MMSE score in the studied group of patients was 28,0 (27,0-28,0). 71 (63,9%) patients scored ≥28 points on the MMSE scale. Mild cognitive impairment (MCI) were detected in 40 (36,1%) people. Among the examined patients there were no patients with dementia. The duration of the observation period was 24,6 (14,4-34,5) months. The combined end point was cardiovascular death, nonfatal myocardial infarction or unstable angina, requiring hospitalization, nonfatal stroke, coronary revascularization.

Results. Events constituting the combined endpoint occurred in 40 (36,0%) patients. According to the results of the Kaplan-Meier analysis, patients with MCI differed significantly lower survival over the observation period of more than 2 years. According to the Cox regression data, MCI was associated with an increase in the relative risk of adverse cardiovascular events constituting the end point, by 2,56 times (95% CI 1,22-5,33; p = 0,013).

Conclusion. The presence of mild cognitive impairment was associated with an increase in the relative risk of adverse cardiovascular events.

About the Authors

В. В. Генкель
ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России
Russian Federation
454092, Челябинск, ул. Воровского, 64


А. С. Кузнецова
ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России
Russian Federation
454092, Челябинск, ул. Воровского, 64


А. О. Салашенко
ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России
Russian Federation
454092, Челябинск, ул. Воровского, 64


Е. В. Лебедев
ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России
Russian Federation
454092, Челябинск, ул. Воровского, 64


И. И. Шапошник
ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России
Russian Federation
454092, Челябинск, ул. Воровского, 64


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For citation:


Генкель В.В., Кузнецова А.С., Салашенко А.О., Лебедев Е.В., Шапошник И.И. Прогностическая значимость умеренных когнитивных нарушений у пациентов с высоким и очень высоким кардиоваскулярным риском. Neurology, Neuropsychiatry, Psychosomatics. 0;. (In Russ.)

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)