Emotional stress-induced transient global amnesia with bilateral hippocampal ischemic lesion
https://doi.org/10.14412/2074-2711-2019-2-89-92
Abstract
The paper describes a clinical case of transient global amnesia (TGA) in a male patient who has experienced prolonged stress at work and at home. The middle-aged man was admitted to hospital disoriented, constantly repeating the same questions. The patient did not remember what had happened that morning before his admission to the hospital. Brain magnetic resonance imaging revealed bilateral punctate hippocampal DWI hyperintensity. The patient has not been observed to have risk factors for cerebrovascular events. Neuropsychological examination has shown that the patient does not have adequate strategies to cope with the sequels of long-term intense stress accompanied with emotion suppression. The described case confirms that psychological instability may be one of the precipitating factors for TGA.
About the Authors
R. Perkovic
Josip Juraj Strossmayer University Medical Center
Croatia
Croatia
Romana Perkovic
Department of Neurology
4, J. Huttlera, Osijek 31000, Croatia
K. Buljan
Josip Juraj Strossmayer University Medical Center
Croatia
Croatia
Department of Neurology
4, J. Huttlera, Osijek 31000, Croatia
M. Vladetic
Josip Juraj Strossmayer University Medical Center
Croatia
Croatia
Department of Neurology
4, J. Huttlera, Osijek 31000, Croatia
F. Katic
Josip Juraj Strossmayer University Medical Center
Croatia
Croatia
Department of Radiology
4, J. Huttlera, Osijek 31000, Croatia
S. Misevic
Josip Juraj Strossmayer University Medical Center
Croatia
Croatia
Department of Neurology
4, J. Huttlera, Osijek 31000, Croatia
S. Butkovic Soldo
Josip Juraj Strossmayer University Medical Center
Croatia
Croatia
Department of Neurology
4, J. Huttlera, Osijek 31000, Croatia
References
1. Hodges JR, Warlow CP. The aetiology of transient global amnesia. A case-control study of 114 cases with prospective follow-up. Brain. 1990 Jun;113 ( Pt 3):639-57.
2. Sander D, Winbeck K, Etgen T, et at. Disturbance of venous flow patterns in patients with transient global amnesia. Lancet. 2000 Dec 9;356(9246):1982-4.
3. Spiegel DR, Smith J, Wade RR, et al. Transient global amnesia: current perspectives. Neuropsychiatr Dis Treat. 2017 Oct 24;13: 2691-2703. doi: 10.2147/NDT.S130710. eCollection 2017.
4. Lin KH, Chen YT, Fuh JL, et al. Migraine is associated with a higher risk of transient global amnesia: a nationwide cohort study. Eur J Neurol. 2014 May;21(5):718-24. doi: 10.1111/ene.12346. Epub 2014 Feb 13.
5. Zeman AZ, Boniface SJ, Hodges JR. Transient epileptic amnesia: a description of the clinical and neuropsychological features in 10 cases and a review of the literature. J Neurol Neurosurg Psychiatry. 1998 Apr;64(4):435-43.
6. Butler CR, Zeman AZ. Recent insights into the impairment of memory in epilepsy: transient epileptic amnesia, accelerated long-term forgetting and remote memory impairment. Brain. 2008 Sep;131(Pt 9):2243-63. doi: 10.1093/brain/awn127. Epub 2008 Jul 9.
7. Rosler A, Mras GJ, Frese A, et al. Precipitating factors of transient global amnesia. J Neurol. 1999 Jan;246(1):53-4.
8. Miller Fischer C. Transient Global Amnesia. Precipitating Activities and Other Observations. Arch Neurol. 1982 Oct;39(10):605-8.
9. Inzitari D, Pantoni L, Lamassa M, et al. Emotional arousal and phobia in transient global amnesia. Arch Neurol. 1997 Jul;54(7):866-73.
10. Dohring J, Schmuck A, Bartsch T. Stressrelated factors in the emergence of transient global amnesia with hippocampal lesion. Front Behav Neurosci. 2014 Aug 29;8:287. doi: 10.3389/fnbeh.2014.00287. eCollection 2014.
11. Szabo K, Forster A, Jager T, et al. Hippocampal lesion patterns in acute posterior cerebral artery stroke: clinical and MRI findings. Stroke. 2009 Jun;40(6):2042-5. doi: 10.1161/STROKEAHA.108.536144. Epub 2009 Apr 9.
12. Bartsch T, Alfke K, Deuschl G, et al. Evolution of hippocampal CA-1 diffusion lesions in transient global amnesia. Ann Neurol. 2007 Nov;62(5):475-80.
13. Kim JJ, Diamond DM. The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci. 2002 Jun;3(6):453-62. doi:10.1038/nrn849
14. McEwen BS. Physiology and neurobiology of stress and adaptation: Central role of the brain. Physiol Rev. 2007 Jul;87(3):873-904. doi: 10.1152/physrev.00041.2006
15. Joels M, Krugers H, Karst H. Stress-induced changes in hippocampal function. Prog Brain Res. 2008;167:3-15. doi: 10.1016/S0079-6123(07)67001-0
16. Joels M. Stress, the hippocampus and epilepsy. Epilepsia. 2009 Apr;50(4):586-97. doi: 10.1111/j.1528-1167.2008.01902.x. Epub 2008 Nov 19.
17. Ay H, Furie KL, Yamada K, et al. Diffusion-weighted MRI characterizes the ischemic lesion in transient global amnesia. Neurology. 1998 Sep;51(3):901-3.
18. Dipu B, Jayeta C, Hrishikesh C, et al. Transient global amnesia: A hippocampal phenomenon: Case report. Pakistan Journal of Medical Sciences. 2014;4(2):56-8.
19. Mohr JP, Leicester J, Stoddard LT, et al. Right hemianopia with memory and color deficits in circumscribed left posterior cerebral artery territory infarction. Neurology. 1971 Nov; 21(11):1104-13.
20. Takahashi S, Higano S, Kurihara N, et al. Correlation of lesions in the hippocampal region noted on MR images with clinical features. Eur Radiol. 1997;7(2):281-6. doi: 10.1007/s003300050151
21. Insausti R, Annese J, Amaral DG, et al. Human amnesia and the medial temporal lobe illuminated by neuropsychological and neurohistological findings for patient E. P. Proc Natl Acad Sci U S A. 2013 May 21;110(21): E1953-62. doi: 10.1073/pnas.1306244110. Epub 2013 Apr 25.
22. Damasio AR, Geschwind N. The Neural Basis of Language. Annu Rev Neurosci. 1984; 7:127-47.
Review
For citations:
Perkovic R., Buljan K., Vladetic M., Katic F., Misevic S., Butkovic Soldo S. Emotional stress-induced transient global amnesia with bilateral hippocampal ischemic lesion. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(2):89-92. (In Russ.) https://doi.org/10.14412/2074-2711-2019-2-89-92
Views: 1184
Email this article 