nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2018-4-13-22nnp-991Research ArticleLECTURESЛЕКЦИЯSporadic cerebral non-amyloid microangiopathy: pathogenesis, diagnosis, and features of treatment policyЦеребральная спорадическая неамилоидная микроангиопатия: патогенез, диагностика и особенности лечебной тактикиКулешА. А.KuleshA. A.

Алексей Александрович Кулеш

614990, Пермь, ул. Петропавловская, 26

Aleksey Aleksandrovich Kulesh

Perm, 26, Petropavlovskaya St., Perm 614990

aleksey.kulesh@gmail.comДробахаВ. Е.DrobakhaV. E.

614990, Пермь, ул. Петропавловская, 26

Perm, 26, Petropavlovskaya St., Perm 614990

ШестаковВ. В.ShestakovV. V.

614990, Пермь, ул. Петропавловская, 26

Perm, 26, Petropavlovskaya St., Perm 614990

ФГБОУВО «Пермский государственный медицинский университет им. акад. Е.А. Вагнера» Минздрава РоссииРоссияAcad. E.A. Vagner Perm State Medical University, Ministry of Health of RussiaRussian Federation2018131220181041322Copyright © Kulesh A.A., Drobakha V.E., Shestakov V.V., 20182018Кулеш А.А., Дробаха В.Е., Шестаков В.В.Kulesh A.A., Drobakha V.E., Shestakov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/991

The paper is devoted to the most common variant of cerebral small-vessel disease Р sporadic cerebral non-amyloid microangiopathy (SCNAMA) in the context of acute and chronic cerebral circulatory disorders. It highlights the topical issues of neuropathology and pathogenesis of the disease. The paper presents the current neuroimaging markers of SCNAMA with a detailed discussion of lacunar infarcts, cerebral microinfarctions, and microbleeds. It considers the clinical manifestations of the chronic form of the disease, including cognitive impairment. The problem in the differential diagnosis of SCNAMA and cerebral amyloid angiopathy is highlighted. The current possibilities of minimizing risks and improving the efficiency of treatment in this category of patients are discussed.

Статья посвящена самому частому варианту церебральной болезни мелких сосудов — спорадической церебральной неамилоидной микроангиопатии (СНАМА) в контексте острого и хронического нарушения мозгового кровообращения. Освещены актуальные вопросы невропатологии и патогенеза заболевания. Представлены современные нейровизуализационные маркеры СНАМА с подробным обсуждением лакунарных инфарктов, церебральных микроинфарктов и микрокровоизлияний. Рассмотрены клинические проявления хронической формы заболевания, в том числе когнитивные нарушения. Освещена проблема дифференциальной диагностики СНАМА и церебральной амилоидной ангиопатии. Обсуждены современные возможности минимизации рисков и повышения эффективности лечения данной категории пациентов.

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The authors declare that there are no conflicts of interest present.