nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2018-4-4-12nnp-990Research ArticleLECTURESЛЕКЦИЯSerotonin and norepinephrine reuptake inhibitor antidepressants: a look through the prism of their 30-year historyАнтидепрессанты - ингибиторы обратного захвата серотонина и норадреналина: взгляд через призму 30-летней историиДаниловД. С.DanilovD. S.

Дмитрий Сергеевич Данилов

Москва, 119021, Москва, ул. Россолимо, 11, стр. 9

Dmitry Sergeevich Danilov

Moscow, 11, Rossolimo St., Build. 9, Moscow 119021

clinica2001@inbox.ruКлиника психиатрии им. С.С. Корсакова Университетской клинической больницы №3; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)» Минздрава РоссииРоссияS.S. Korsakov Clinic of Psychiatry; University Clinical Hospital Three, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian Federation201813122018104412Copyright © Danilov D.S., 20182018Данилов Д.С.Danilov D.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/990

Based on the data available in the literature, the author has first systematized in detail the main stages of the design and clinical introduction of serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressants. Theoretical prerequisites for their emergence are described. The evaluation of the efficiency of depression therapy with drugs of this group in clinical trials and post-marketing studies is analyzed in the historical context. The reasons for temporary restrictions on their wide use are considered. There are data on the design of novel representatives of SNRI antidepressants.

На основании анализа данных литературы впервые подробно систематизированы основные этапы создания и введения в клиническую практику антидепрессантов — ингибиторов обратного захвата серотонина и норадреналина (ИОЗСН). Описаны теоретические предпосылки для их появления. В историческом контексте проанализирована оценка эффективности терапии депрессии препаратами этой группы на этапе клинических испытаний и в постмаркетинговый период. Рассмотрены причины временного введения ограничений для их широкого использования. Представлены данные о создании новых представителей антидепрессантов — ИОЗСН.

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The authors declare that there are no conflicts of interest present.