nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2011-337nnp-97Research ArticleLECTURESЛЕКЦИЯNew criteria for diagnosing Alzheimer's diseaseНовые критерии диагностики болезни АльцгеймераЕмелинА. Ю.EmelinA. Yu.

Кафедра нервных болезней

Санкт-Петербург

Department of Nervous Diseases

Saint Petersburg

emelinand@rambler.ruВМА им. С.М. КироваРоссияS.M. Kirov Military Medical AcademyRussian Federation20111412201134NO4 (2011)58Copyright © Emelin A.Y., 20112011Емелин А.Ю.Emelin A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/97

The paper gives an analysis of new diagnostic criteria for different stages of Alzheimer Х s disease (AD), which is proposed by the U.S. National Institute on Aging. It considers possibilities for the early diagnosis of AD, including its preclinical diagnosis using the laboratory and neuroimaging markers beta-amyloid, neuronal damage.

Представлен анализ новых критериев диагностики разных стадий болезни Альцгеймера (БА), предложенный Национальным институтом старения США. Рассмотрены возможности ранней диагностики БА, включая доклиническую диагностику с использованием лабораторных и нейровизуализационных маркеров бета-амилоида, нейронального повреждения.

когнитивные нарушениядеменцияболезнь Альцгеймеракритерии диагностикиcognitive impairmentsdementiaAlzheimer's diseasediagnostic criteriaReferences<div><p>Яхно Н.Н., Захаров В.В., Локшина А.Б. и др. Деменции: рук-во для врачей. 3-е изд. М.: МЕДпресс-информ, 2011;272 с.</p><p>Международная статистическая классификация болезней и проблем, связанных со здоровьем. Десятый пересмотр (МКБ10). Т.1 (часть 1). Женева: ВОЗ;1995:315;510–51.</p><p>McKhann G., Drachman D., Folstein M. et al. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS–ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984;34(7):939–44.</p><p>McKhann G.M., Knopman D.S., Chertkow H. et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheim dement 2011;7(3):263–9.</p><p>Davis D.G., Schmitt F.A., Wekstein D.R. et al. Alzheimer neuropathologic alterations in aged cognitively normal subjects. J neuropathol exp neurol 1999;58(4):376–88.</p><p>Knopman D.S., Parisi J.E., Salviati A. et al. Neuropathology of cognitively normal elderly. J neuropathol exp neurol 2003;62(11):1087–95.</p><p>Bennett D.A., Schneider J.A., Arvanitakis Z. et al. Neuropathology of older persons without cognitive impairment from two community–based studies. Neurology 2006;66(12):1837–44.</p><p>Sperling R.A., Aisen P.S., Beckett L.A. et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheim dement 2011;7(3):280–92.</p><p>Jack C.R., Albert M.S., Knopman D.S. et al. Introduction to the recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheim dement 2011;7(3):257–62.</p><p>Емелин А.Ю., Одинак М.М., Труфанов Г.Е. и др. Возможности позитронной эмиссионной томографии в дифференциальной диагностике деменций. Вестн Рос Воен мед акад 2010;4(32):46–51.</p><p>Blennow K., Hampel H., Weiner M. et al. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat rev neurol 2010;6(3):131–44.</p><p>Mintun M.A., Larossa G.N., Sheline Y.I. et al.C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 2006;67(3):446–52.</p><p>Stern Y. Cognitive reserve. Neuropsychologia 2009;47:2015–28.</p><p>Tapiola T., Alafuzoff I., Herukka S.K. et al. Cerebrospinal fluid β-amyloid 42 and tau proteins as biomarkers of Alzheimer–type pathologic changes in the brain. Arch neurol 2009;66(3):382–89.</p><p>Albert M.S., DeKosky S.T., Dickson D. et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheim Dement 2011;7(3):270–9.</p><p>Jack C.R. Knopman D.S., Jagust W.J. et al. Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet neurol 2010;9(1):119–28.</p><p>Sheline Y.I., Morris J.C., Snyder A.Z. et al. APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Abeta42. J neurosci 2010;30(50):17035–40.</p><p>Vemuri P., Wiste H.J., Weigand S.D. et al. Serial MRI and CSF biomarkers in normal aging, MCI, and AD. Neurology 2010;75(2):143–51.</p><p>Яхно Н.Н., Локшина А.Б., Захаров В.В. Легкие и умеренные когнитивные расстройства при дисциркуляторной энцефалопатии. Клин геронтол 2005;11(9):38–9.</p><p>Dubois B., Feldman H., Jacova C. et al. Revising the definition of Alzheimer's disease: a new lexicon. Lancet neurol 2010;9(11):1118–27.</p><p>Petersen R.C. Mild cognitive impairment. J int med 2004;256(3):183–94.</p><p>Petersen R.C., Smith G.E., Waring S.C. et al. Mild Cognitive Impairment: Clinical Characterization and Outcome. Arch neurol 1999;56(3):303–8.</p><p>Одинак М.М., Емелин А.Ю., Декан В.С. и др. Современные возможности нейровизуализации в диагностике деменций. Психиатрия 2009;1(37):57–61.</p><p>Одинак М.М., Емелин А.Ю., Лобзин В.Ю. и др. Церебральная перфузия и когнитивные нарушения у больных с сосудистой деменцией. Мед акад журн 2011;11(1):58–64.</p><p>Atiya M., Hyman B., Albert M. et al. Structural magnetic resonance imaging in established and prodromal Alzheimer’s disease: a review. Alzheim dis ass dis 2003;17(3):177–95.</p><p>Jagust W. Positron emission tomography and magnetic resonance imaging in the diagnosis and prediction of dementia. Alzheim dement 2006;2(1):36–42.</p><p>Kantarci K., Jack C. Neuroimaging in Alzheim&lt;None&gt;er’s disease: an evidenced–based review. Neuroimag clin north am 2003;13(2):197–209.</p><p>Dubois B., Albert M.L. Amnestic MCI or prodromal Alzheimer’s disease- Lancet neurol 2004;3(4):246–48.</p><p>Sohrabi H., Weinborn M., Badcock J. et al. New lexicon and criteria for the diagnosis of Alzheimer's disease. Lancet neurol 2011;10(4):299–300.</p><p>Iversen L.L. Differences between early and late–onset Alzheimer's disease. Neurobiol aging 1987;8(6):554–5.</p></div><br /><div><p>Яхно Н.Н., Захаров В.В., Локшина А.Б. и др. Деменции: рук-во для врачей. 3-е изд. М.: МЕДпресс-информ, 2011;272 с.</p><p>Международная статистическая классификация болезней и проблем, связанных со здоровьем. Десятый пересмотр (МКБ10). Т.1 (часть 1). Женева: ВОЗ;1995:315;510–51.</p><p>McKhann G., Drachman D., Folstein M. et al. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS–ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984;34(7):939–44.</p><p>McKhann G.M., Knopman D.S., Chertkow H. et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheim dement 2011;7(3):263–9.</p><p>Davis D.G., Schmitt F.A., Wekstein D.R. et al. Alzheimer neuropathologic alterations in aged cognitively normal subjects. J neuropathol exp neurol 1999;58(4):376–88.</p><p>Knopman D.S., Parisi J.E., Salviati A. et al. Neuropathology of cognitively normal elderly. J neuropathol exp neurol 2003;62(11):1087–95.</p><p>Bennett D.A., Schneider J.A., Arvanitakis Z. et al. Neuropathology of older persons without cognitive impairment from two community–based studies. Neurology 2006;66(12):1837–44.</p><p>Sperling R.A., Aisen P.S., Beckett L.A. et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheim dement 2011;7(3):280–92.</p><p>Jack C.R., Albert M.S., Knopman D.S. et al. Introduction to the recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheim dement 2011;7(3):257–62.</p><p>Емелин А.Ю., Одинак М.М., Труфанов Г.Е. и др. Возможности позитронной эмиссионной томографии в дифференциальной диагностике деменций. Вестн Рос Воен мед акад 2010;4(32):46–51.</p><p>Blennow K., Hampel H., Weiner M. et al. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat rev neurol 2010;6(3):131–44.</p><p>Mintun M.A., Larossa G.N., Sheline Y.I. et al.C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 2006;67(3):446–52.</p><p>Stern Y. Cognitive reserve. Neuropsychologia 2009;47:2015–28.</p><p>Tapiola T., Alafuzoff I., Herukka S.K. et al. Cerebrospinal fluid β-amyloid 42 and tau proteins as biomarkers of Alzheimer–type pathologic changes in the brain. Arch neurol 2009;66(3):382–89.</p><p>Albert M.S., DeKosky S.T., Dickson D. et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheim Dement 2011;7(3):270–9.</p><p>Jack C.R. Knopman D.S., Jagust W.J. et al. Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet neurol 2010;9(1):119–28.</p><p>Sheline Y.I., Morris J.C., Snyder A.Z. et al. APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Abeta42. J neurosci 2010;30(50):17035–40.</p><p>Vemuri P., Wiste H.J., Weigand S.D. et al. Serial MRI and CSF biomarkers in normal aging, MCI, and AD. Neurology 2010;75(2):143–51.</p><p>Яхно Н.Н., Локшина А.Б., Захаров В.В. Легкие и умеренные когнитивные расстройства при дисциркуляторной энцефалопатии. Клин геронтол 2005;11(9):38–9.</p><p>Dubois B., Feldman H., Jacova C. et al. Revising the definition of Alzheimer's disease: a new lexicon. Lancet neurol 2010;9(11):1118–27.</p><p>Petersen R.C. Mild cognitive impairment. J int med 2004;256(3):183–94.</p><p>Petersen R.C., Smith G.E., Waring S.C. et al. Mild Cognitive Impairment: Clinical Characterization and Outcome. Arch neurol 1999;56(3):303–8.</p><p>Одинак М.М., Емелин А.Ю., Декан В.С. и др. Современные возможности нейровизуализации в диагностике деменций. Психиатрия 2009;1(37):57–61.</p><p>Одинак М.М., Емелин А.Ю., Лобзин В.Ю. и др. Церебральная перфузия и когнитивные нарушения у больных с сосудистой деменцией. Мед акад журн 2011;11(1):58–64.</p><p>Atiya M., Hyman B., Albert M. et al. Structural magnetic resonance imaging in established and prodromal Alzheimer’s disease: a review. Alzheim dis ass dis 2003;17(3):177–95.</p><p>Jagust W. Positron emission tomography and magnetic resonance imaging in the diagnosis and prediction of dementia. Alzheim dement 2006;2(1):36–42.</p><p>Kantarci K., Jack C. Neuroimaging in Alzheim&lt;None&gt;er’s disease: an evidenced–based review. Neuroimag clin north am 2003;13(2):197–209.</p><p>Dubois B., Albert M.L. Amnestic MCI or prodromal Alzheimer’s disease- Lancet neurol 2004;3(4):246–48.</p><p>Sohrabi H., Weinborn M., Badcock J. et al. New lexicon and criteria for the diagnosis of Alzheimer's disease. Lancet neurol 2011;10(4):299–300.</p><p>Iversen L.L. Differences between early and late–onset Alzheimer's disease. Neurobiol aging 1987;8(6):554–5.</p></div><br />

The authors declare that there are no conflicts of interest present.