nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2018-3-108-115nnp-958Research ArticleREVIEWSОБЗОРЫPlacebo analgesiaПлацебо-аналгезияТабееваГ. Р.TabeevaG. R.

Кафедра нервных болезней и нейрохирургии лечебного факультета

Department of Nervous System Diseases and Neurosurgery, Faculty of General Medicine

grtabeeva@gmail.comФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)» Минздрава России, МоскваРоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, MoscowRussian Federation201808112018103108115Copyright © Tabeeva G.R., 20182018Табеева Г.Р.Tabeeva G.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/958

Placebos are drugs, devices, or other treatments that are physically and pharmacologically inert. The placebo effects are therapeutic responses to the context of the treatment process. They are mediated by factors, such as training of a patient, his/her expectations associated with treatment, as well as social conditions, the features of cognitive functioning, etc. and can affect the clinical and physiological responses caused by the health status. The analgesic effects of placebo in different types of pain syndromes reach 25–80%. The formation of placebo analgesia involves the brain structures that belong to the pain matrix and are implicated in the basic processes of perception, in the mechanisms of pain modulation, and in a number of other cognitive and affective processes, as well as in the emotional reactions not caused by pain. A deeper understanding of the mechanisms of action of placebo analgesia can optimize the strategy of current pain therapy.

Плацебо – это лекарства, устройства или другие виды лечения, которые физически и фармакологически инертны. Эффекты плацебо представляют собой терапевтические ответы на контекст лечебного процесса. Они опосредуются такими факторами, как обучение пациента, его ожидания, связанные с лечением, социальные условия, особенности когнитивного функционирования и др., и могут влиять на клинические и физиологические реакции, обусловленные состоянием здоровья. Анальгетические эффекты плацебо при различных формах болевых синдромов достигают 25–80%. В формировании плацебо-аналгезии участвуют мозговые структуры, которые относятся к «болевой матрице» и задействованы в базовых процессах перцепции, механизмах модуляции боли и ряде других когнитивных и аффективных процессов, а также эмоциональных реакций, не вызванных болью. Углубленные представления о механизмах действия плацебо-аналгезии позволяют оптимизировать стратегии современной терапии боли.

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The authors declare that there are no conflicts of interest present.