nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2018-3-12-18nnp-943Research ArticleLECTURESЛЕКЦИЯPeripheral nervous system involvement in systemic amyloidosisПоражение периферической нервной системы при системном амилоидозеСафиулинаЭ. И.SafiulinaE. I.

Кафедра нервных болезней и нейрохирургии лечебного факультета

Department of Nervous System Diseases and Neurosurgery, Faculty of General Medicine

ЗиновьеваО. Е.ZinovyevaO. E.

Кафедра нервных болезней и нейрохирургии лечебного факультета

Department of Nervous System Diseases and Neurosurgery, Faculty of General Medicine

zinovyevaolga@yandex.ruРамеевВ. В.RameevV. V.

кафедра внутренних, профессиональных болезней и пульмонологии медико-профилактического факультета

Department of Internal Medicine, Occupational Diseases, and Pulmonology, Faculty of Preventive Medicine

Козловская-ЛысенкоЛ. В.Kozlovskaya-LysenkoL. V.

кафедра внутренних, профессиональных болезней и пульмонологии медико-профилактического факультета

Department of Internal Medicine, Occupational Diseases, and Pulmonology, Faculty of Preventive Medicine

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)» Минздрава России, МоскваРоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, MoscowRussian Federation2018081120181031218Copyright © Safiulina E.I., Zinovyeva O.E., Rameev V.V., Kozlovskaya-Lysenko L.V., 20182018Сафиулина Э.И., Зиновьева О.Е., Рамеев В.В., Козловская-Лысенко Л.В.Safiulina E.I., Zinovyeva O.E., Rameev V.V., Kozlovskaya-Lysenko L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/943

Peripheral nervous system involvement may be a main manifestation of systemic amyloidosis or occur in the later stages of the disease in the presence of multiple organ pathology. Focal, multiple mononeuropathy, radiculopathy, polyneuropathy, autonomic nervous system dysfunction, and myopathy develop depending on the localization of amyloid deposits in the peripheral nervous system. The most characteristic symptom in systemic amyloidosis is sensorimotor polyneuropathy accompanied in most cases by the involvement of autonomic nerve fibers in the pathological process. In cases of systemic amyloidosis, peripheral nervous system involvement is progressive, leading to disability, which makes the early diagnosis of the disease and its neurological manifestations and subsequent pathogenetic therapy relevant.

Поражение периферической нервной системы может быть основным проявлением системного амилоидоза либо возникать на поздних стадиях заболевания на фоне полиорганной патологии. В зависимости от локализации отложений амилоида в периферической нервной системе развиваются фокальная, множественная мононевропатия, радикулопатия, полиневропатия, дисфункция вегетативной нервной системы, миопатия. Наиболее характерным симптомом при системном амилоидозе является сенсорно-моторная полиневропатия, сопровождающаяся в большинстве случаев вовлечением в патологический процесс вегетативных нервных волокон. Поражение периферической нервной системы в случаях системного амилоидоза носит прогрессирующий характер, приводя к инвалидизации пациента, что делает актуальной раннюю диагностику заболевания и его неврологических проявлений с последующим проведением патогенетической терапии.

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The authors declare that there are no conflicts of interest present.