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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2018-2-45-51</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-884</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>The relationship and interaction of menstrual and generative function and depressive disorders in women</article-title><trans-title-group xml:lang="ru"><trans-title>Взаимосвязь и взаимовлияние менструально-генеративной функции и депрессивных расстройств у женщин</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тювина</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tyuvina</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Контакты: Нина Аркадьевна Тювина </p><p>Кафедра психиатрии и наркологии </p><p>119021, Москва, ул. Россолимо, 11, стр. 9</p></bio><bio xml:lang="en"><p>Contact: Nina Arkadyevna Tyuvina</p><p>Department of Psychiatry and Narcology </p><p>11, Rossolimo St., Build. 9, Moscow 119021 </p></bio><email xlink:type="simple">natuvina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воронина</surname><given-names>Е. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Voronina</surname><given-names>E. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра психиатрии и наркологии </p><p>119021, Москва, ул. Россолимо, 11, стр. 9</p></bio><bio xml:lang="en"><p>Department of Psychiatry and Narcology </p><p>11, Rossolimo St., Build. 9, Moscow 119021 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балабанова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Balabanova</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра психиатрии и наркологии </p><p>119021, Москва, ул. Россолимо, 11, стр. 9</p></bio><bio xml:lang="en"><p>Department of Psychiatry and Narcology </p><p>11, Rossolimo St., Build. 9, Moscow 119021 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гончарова</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Goncharova</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра психиатрии и наркологии </p><p>119021, Москва, ул. Россолимо, 11, стр. 9</p></bio><bio xml:lang="en"><p>Department of Psychiatry and Narcology </p><p>11, Rossolimo St., Build. 9, Moscow 119021 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>24</day><month>06</month><year>2018</year></pub-date><volume>10</volume><issue>2</issue><fpage>45</fpage><lpage>51</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Tyuvina N.A., Voronina E.O., Balabanova V.V., Goncharova E.M., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Тювина Н.А., Воронина Е.О., Балабанова В.В., Гончарова Е.М.</copyright-holder><copyright-holder xml:lang="en">Tyuvina N.A., Voronina E.O., Balabanova V.V., Goncharova E.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/884">https://nnp.ima-press.net/nnp/article/view/884</self-uri><abstract><sec><title>Objective</title><p>Objective: to study of the individual aspects of the relationship and interaction of menstrual and generative function and depressive disorders in women. </p></sec><sec><title>Patients and methods</title><p>Patients and methods. 120 women aged 18–65 years with recurrent depressive disorder (RDD) who had experienced at least two depressive episodes (a study group) and 120 mentally healthy women of the same age (a control group) were clinically examined using a specially designed map with subsequent statistical processing of the findings. </p></sec><sec><title>Results and discussion</title><p>Results and discussion. In 71.7% of women, depression manifests itself during hormonal rearrangement periods (puberty, postpartum, and menopause). 65.0% of women with RDD have premenstrual syndrome (PMS), the pattern of which shows depressive symptoms. Depression affects menstrual function: the later onset and irregularity of menstruation, the earlier restoration of menstrual function after childbirth, and the earlier onset of premenopause, which has an adverse impact on generative function (a reduction in the number of pregnancies, births, and babies). Depression, the onset of which is observed during puberty, exerts the most malignant effect on menstrual and generative function. Overall, depressive patients are less socially and family-friendly than healthy women. Menstrual and generative function and adaptation minimally suffer in women with postmenopausal depression. </p></sec><sec><title>Conclusion</title><p>Conclusion. The onset of depressive disorders is associated with the hormonal rearrangement periods. The presence of depressive symptoms in the pattern of PMS is a prognostic sign of future depression or indicates partial remission. At the same time, menstrual function is impaired in women suffering from RDD, which along with psychic manifestations of depression (a decrease in sexual drive and contacts, as well as anesthesia of feelings, etc.) leads to infertility. </p></sec></abstract><trans-abstract xml:lang="ru"><p>Цель исследования – изучение отдельных аспектов взаимосвязи и взаимовлияния менструально-генеративной функции и депрессивных расстройств у женщин. </p><sec><title>Пациенты и методы</title><p>Пациенты и методы. Обследовано 120 женщин в возрасте 18–65 лет с рекуррентным депрессивным расстройством (РДР), перенесших не менее двух эпизодов депрессии (основная группа), и 120 психически здоровых женщин того же возраста (контрольная группа). Обследование проводилось клиническим методом с помощью специально разработанной карты с последующей статистической обработкой полученных данных. </p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. У 71,7% женщин депрессия манифестирует в периоды гормональной перестройки (пубертат, послеродовый период, климактерий). У 65,0% женщин, страдающих РДР, имеется предменструальный синдром (ПМС), в структуре которого проявляется депрессивная симптоматика. Депрессия оказывает влияние на менструальную функцию: более позднее начало и нерегулярность менструаций, более раннее восстановление менструальной функции после родов, более раннее наступление пременопаузы, что неблагоприятно сказывается на генеративной функции (уменьшается количество беременностей, родов, детей). Наиболее злокачественной по влиянию на менструально-генеративную функцию является депрессия, дебют которой приходится на период пубертата. В целом пациентки с депрессией менее адаптированы в социальном и семейном плане, чем здоровые женщины. В минимальной степени менструально-генеративная функция и адаптация страдают у женщин с манифестацией депрессии в постменопаузе. </p></sec><sec><title>Заключение</title><p>Заключение. Начало депрессивных расстройств связано с периодами гормональной перестройки. Наличие депрессивных симптомов в структуре ПМС является прогностическим признаком будущей депрессии либо свидетельствует о неполной ремиссии. В то же время у женщин, страдающих РДР, нарушается менструальная функция, что наряду с психическими проявлениями депрессии (снижение сексуального влечения, общения, анестезия чувств и др.) ведет к нарушению детородной функции. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>рекуррентное депрессивное расстройство</kwd><kwd>депрессия у женщин</kwd><kwd>менструально-генеративная функция</kwd><kwd>пубертат</kwd><kwd>послеродовый период</kwd><kwd>климактерий</kwd><kwd>предменструальный синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>recurrent depressive disorder</kwd><kwd>depression in women</kwd><kwd>menstrual and generative function</kwd><kwd>puberty</kwd><kwd>postpartum</kwd><kwd>menopause</kwd><kwd>premenstrual syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Тювина НА. Депрессии у женщин. 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