<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2018-1-96-101</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-839</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Vestibular vertigo treatment in a polymorbid patient</article-title><trans-title-group xml:lang="ru"><trans-title>Лечение вестибулярного головокружения у полиморбидного пациента</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косивцова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosivtsova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра нервных болезней и нейрохирургии,</p><p>119021, Москва, ул. Россолимо, 11</p></bio><bio xml:lang="en"><p>Department of Nervous System Diseases and Neurosurgery, </p><p>11, Rossolimo St., Moscow 119021</p></bio><email xlink:type="simple">o.kosivtsova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яворская</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Yavorskaya</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра нервных болезней и нейрохирургии,</p><p>119021, Москва, ул. Россолимо, 11</p></bio><bio xml:lang="en"><p>Department of Nervous System Diseases and Neurosurgery, </p><p>11, Rossolimo St., Moscow 119021</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фатеева</surname><given-names>Т. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Fateeva</surname><given-names>T. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра нервных болезней и нейрохирургии,</p><p>119021, Москва, ул. Россолимо, 11</p></bio><bio xml:lang="en"><p>Department of Nervous System Diseases and Neurosurgery, </p><p>11, Rossolimo St., Moscow 119021</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>02</day><month>04</month><year>2018</year></pub-date><volume>10</volume><issue>1</issue><fpage>96</fpage><lpage>101</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kosivtsova O.V., Yavorskaya S.A., Fateeva T.G., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Косивцова О.В., Яворская С.А., Фатеева Т.Г.</copyright-holder><copyright-holder xml:lang="en">Kosivtsova O.V., Yavorskaya S.A., Fateeva T.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/839">https://nnp.ima-press.net/nnp/article/view/839</self-uri><abstract><p>Many physicians have difficulty managing patients with vertigo. Incorrect routine diagnoses are frequently made in patients with peripheral vestibulopathy, which makes therapy fail. Most cases of vestibular vertigo are caused by peripheral vestibular disorders (otolithiasis, hydrops, neuronitis). Rehabilitation maneuvers are effective in the treatment of benign paroxysmal positional dizziness; salt-free diet, diuretics, and betahistine dihydrochloride are for MОniПre’s disease (syndrome); vestibular rehabilitation is for vestibular neuronitis. Betahistine dihydrochloride is most effective among all the medicines used in different causes of vestibular vertigo, including that of unclear origin. The paper gives the positive experience with betahistine made in Russia for vestibular vertigo.</p></abstract><trans-abstract xml:lang="ru"><p>Ведение пациентов с головокружением вызывает трудности у многих врачей. Часто пациентам с периферической вестибулопатией устанавливают неверные «шаблонные» диагнозы, что приводит к назначению неэффективной терапии. Вестибулярное головокружение в большинстве случаев вызвано патологией периферического вестибулярного аппарата (отолитиаз, гидропс, нейронит). При лечении доброкачественного пароксизмального позиционного головокружения эффективны реабилитационные маневры; при болезни (синдром) Меньера – бессолевая диета, диуретики, бетагистина дигидрохлорид; при вестибулярном нейроните – вестибулярная реабилитация. Из всех лекарственных средств, применяемых при различных причинах вестибулярного головокружения, в том числе при неясном головокружении, наиболее эффективен бетагистина дигидрохлорид. Приведен положительный опыт применения отечественного бетагистина при вестибулярном головокружении.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>головокружение</kwd><kwd>лечение</kwd><kwd>вестибулосупрессивная терапия</kwd><kwd>доброкачественное пароксизмальное позиционное головокружение</kwd><kwd>болезнь (синдром) Меньера</kwd><kwd>вестибулярный нейронит</kwd><kwd>полиморбидность</kwd><kwd>вестибулярная реабилитация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>vertigo</kwd><kwd>treatment</kwd><kwd>vestibular suppressive therapy</kwd><kwd>benign paroxysmal vertigo</kwd><kwd>Meniere's disease (syndrome)</kwd><kwd>vestibular neuronitis</kwd><kwd>polymorbidity</kwd><kwd>vestibular rehabilitation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Абдулина ОВ, Замерград МВ. Дифференциальный диагноз, прогноз и лечение острого вестибулярного головокружения. Неврологический журнал 2007;(6):21-5. [Parfenov VA, Abdulina OV, Zamergrad MV. Differential diagnosis, prognosis and treatment of acute vestibular dizziness. Nevrologicheskii zhurnal 2007;(6):21-5. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Парфенов ВА, Абдулина ОВ, Замерград МВ. Дифференциальный диагноз, прогноз и лечение острого вестибулярного головокружения. Неврологический журнал 2007;(6):21-5. [Parfenov VA, Abdulina OV, Zamergrad MV. Differential diagnosis, prognosis and treatment of acute vestibular dizziness. Nevrologicheskii zhurnal 2007;(6):21-5. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Абдулина ОВ, Замерград МВ. Периферическая вестибулопатия под маской инсульта. Неврологический журнал. 2005;(6):28-32. [Parfenov VA, Abdulina OV, Zamergrad MV. Peripheral vestibulopathy under the mask of stroke. Nevrologicheskii zhurnal. 2005;(6):28-32. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Парфенов ВА, Абдулина ОВ, Замерград МВ. Периферическая вестибулопатия под маской инсульта. Неврологический журнал. 2005;(6):28-32. [Parfenov VA, Abdulina OV, Zamergrad MV. Peripheral vestibulopathy under the mask of stroke. Nevrologicheskii zhurnal. 2005;(6):28-32. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Самородская ИВ, Андреев ЕМ, Заратьянц ОВ и др. Показатели смертности населения старше 50 лет от цереброваскулярных болезней за 15-летний период в России и США. Неврология, нейропсихиатрия, психосоматика. 2017;9(2):15-24. [Samorodskaya IV, Andreev EM, Zarat'yants OV, et al. Cerebrovascular disease mortality rates in the population over 50 years of age in Russia and the USA over a 15-year period. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2017;9(2):15-24. (In Russ.)]. doi: 10.14412/2074-2711-2017-2-15-24</mixed-citation><mixed-citation xml:lang="en">Самородская ИВ, Андреев ЕМ, Заратьянц ОВ и др. Показатели смертности населения старше 50 лет от цереброваскулярных болезней за 15-летний период в России и США. Неврология, нейропсихиатрия, психосоматика. 2017;9(2):15-24. [Samorodskaya IV, Andreev EM, Zarat'yants OV, et al. Cerebrovascular disease mortality rates in the population over 50 years of age in Russia and the USA over a 15-year period. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2017;9(2):15-24. (In Russ.)]. doi: 10.14412/2074-2711-2017-2-15-24</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Barnett K, Mercer SW, Norbury M, et al. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012 Jul 7;380(9836):37-43. doi: 10.1016/S0140-6736(12)60240-2. Epub 2012 May 10.</mixed-citation><mixed-citation xml:lang="en">Barnett K, Mercer SW, Norbury M, et al. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012 Jul 7;380(9836):37-43. doi: 10.1016/S0140-6736(12)60240-2. Epub 2012 May 10.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Leatham AM. Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. Clin Pharm. 1986 Aug;5(8):660-8.</mixed-citation><mixed-citation xml:lang="en">Leatham AM. Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. Clin Pharm. 1986 Aug;5(8):660-8.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Strupp M, Arbusow V, Brandt T. Exercise and drug therapy alter recovery from labyrinth lesion in humans. Ann N Y Acad Sci. 2001 Oct;942:79-94.</mixed-citation><mixed-citation xml:lang="en">Strupp M, Arbusow V, Brandt T. Exercise and drug therapy alter recovery from labyrinth lesion in humans. Ann N Y Acad Sci. 2001 Oct;942:79-94.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Woodworth BA, Gillespie MB, Lambert PR. The canalith repositioning procedure for benign positional vertigo: a meta-analysis. Laryngoscope. 2004 Jul;114(7):1143-6.</mixed-citation><mixed-citation xml:lang="en">Woodworth BA, Gillespie MB, Lambert PR. The canalith repositioning procedure for benign positional vertigo: a meta-analysis. Laryngoscope. 2004 Jul;114(7):1143-6.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hilton MP, Pinder DK. The Epley (canalith repositioning) manoeuvre for benign paroxysmal positional vertigo. Cochrane Database Syst Rev. 2014 Dec 8;(12):CD003162. doi: 10.1002/14651858.CD003162.pub3.</mixed-citation><mixed-citation xml:lang="en">Hilton MP, Pinder DK. The Epley (canalith repositioning) manoeuvre for benign paroxysmal positional vertigo. Cochrane Database Syst Rev. 2014 Dec 8;(12):CD003162. doi: 10.1002/14651858.CD003162.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Fife TD, Iverson DJ, Lempert T, et al; Quality Standards Subcommittee, American Academy of Neurology. Practice parameter: therapies for benign paroxysmal positional vertigo (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2008 May 27;70(22):2067-74. doi: 10.1212/01.wnl.0000313378.77444.ac.</mixed-citation><mixed-citation xml:lang="en">Fife TD, Iverson DJ, Lempert T, et al; Quality Standards Subcommittee, American Academy of Neurology. Practice parameter: therapies for benign paroxysmal positional vertigo (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2008 May 27;70(22):2067-74. doi: 10.1212/01.wnl.0000313378.77444.ac.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Guneri EA, Kustutan O. The effects of betahistine in addition to Epley maneuver in posterior canal benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg. 2012 Jan;146(1):104-8. doi: 10.1177/0194599811419093. Epub 2011 Aug 18.</mixed-citation><mixed-citation xml:lang="en">Guneri EA, Kustutan O. The effects of betahistine in addition to Epley maneuver in posterior canal benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg. 2012 Jan;146(1):104-8. doi: 10.1177/0194599811419093. Epub 2011 Aug 18.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Teggi R, Giordano L, Bondi S, et al. Residual dizziness after successful repositioning maneuvers for idiopathic benign paroxysmal positional vertigo in the elderly. Eur Arch Otorhinolaryngol. 2011 Apr;268(4):507-11. doi: 10.1007/s00405-010-1422-9. Epub 2010 Nov 11.</mixed-citation><mixed-citation xml:lang="en">Teggi R, Giordano L, Bondi S, et al. Residual dizziness after successful repositioning maneuvers for idiopathic benign paroxysmal positional vertigo in the elderly. Eur Arch Otorhinolaryngol. 2011 Apr;268(4):507-11. doi: 10.1007/s00405-010-1422-9. Epub 2010 Nov 11.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Radtke A, Neuhauser H, von Brevern M, Lempert T. A modified Epley's procedure for self-treatment of benign paroxysmal positional vertigo. Neurology. 1999 Oct 12;53(6):1358-60.</mixed-citation><mixed-citation xml:lang="en">Radtke A, Neuhauser H, von Brevern M, Lempert T. A modified Epley's procedure for self-treatment of benign paroxysmal positional vertigo. Neurology. 1999 Oct 12;53(6):1358-60.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Tanimoto H, Doi K, Katata K, Nibu KI. Self-treatment for benign paroxysmal positional vertigo of the posterior semicircular canal. Neurology. 2005 Oct 25;65(8):1299-300.</mixed-citation><mixed-citation xml:lang="en">Tanimoto H, Doi K, Katata K, Nibu KI. Self-treatment for benign paroxysmal positional vertigo of the posterior semicircular canal. Neurology. 2005 Oct 25;65(8):1299-300.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Furman JM, Hain TC. «Do try this at home»: self-treatment of BPPV. Neurology. 2004 Jul 13;63(1):8-9.</mixed-citation><mixed-citation xml:lang="en">Furman JM, Hain TC. «Do try this at home»: self-treatment of BPPV. Neurology. 2004 Jul 13;63(1):8-9.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen HS, Sangi-Haghpeykar H. Canalith repositioning variations for benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg. 2010 Sep;143(3):405-12. doi: 10.1016/j.otohns. 2010.05.022.</mixed-citation><mixed-citation xml:lang="en">Cohen HS, Sangi-Haghpeykar H. Canalith repositioning variations for benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg. 2010 Sep;143(3):405-12. doi: 10.1016/j.otohns. 2010.05.022.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Herdman SJ, Tusa RJ. Complications of the canalith repositioning procedure. Arch Otolaryngol Head Neck Surg. 1996 Mar;122(3):281-6.</mixed-citation><mixed-citation xml:lang="en">Herdman SJ, Tusa RJ. Complications of the canalith repositioning procedure. Arch Otolaryngol Head Neck Surg. 1996 Mar;122(3):281-6.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Thorp MA, Shehab ZP, Bance ML, Rutka JA. Does evidence-based medicine exist in the treatment of Meniere's disease? A critical review of the last decade of publications. Clin Otolaryngol Allied Sci. 2000 Dec;25(6):456-60.</mixed-citation><mixed-citation xml:lang="en">Thorp MA, Shehab ZP, Bance ML, Rutka JA. Does evidence-based medicine exist in the treatment of Meniere's disease? A critical review of the last decade of publications. Clin Otolaryngol Allied Sci. 2000 Dec;25(6):456-60.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Santos PM, Hall RA, Snyder JM, et al. Diuretic and diet effect on Meniere's disease evaluated by the 1985 Committee on Hearing and Equilibrium guidelines. Otolaryngol Head Neck Surg. 1993 Oct;109(4):680-9.</mixed-citation><mixed-citation xml:lang="en">Santos PM, Hall RA, Snyder JM, et al. Diuretic and diet effect on Meniere's disease evaluated by the 1985 Committee on Hearing and Equilibrium guidelines. Otolaryngol Head Neck Surg. 1993 Oct;109(4):680-9.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Coelho DH, Lalwani AK. Medical management of Meniere's disease. Laryngoscope. 2008 Jun;118(6):1099-108. doi: 10.1097/MLG.0b013e31816927f0.</mixed-citation><mixed-citation xml:lang="en">Coelho DH, Lalwani AK. Medical management of Meniere's disease. Laryngoscope. 2008 Jun;118(6):1099-108. doi: 10.1097/MLG.0b013e31816927f0.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Claes J, Van de Heyning PH. A review of medical treatment for Meniere's disease. Acta Otolaryngol Suppl. 2000;544:34-9.</mixed-citation><mixed-citation xml:lang="en">Claes J, Van de Heyning PH. A review of medical treatment for Meniere's disease. Acta Otolaryngol Suppl. 2000;544:34-9.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Strupp M, Zingler VC, Arbusow V, et al. Methylprednisolone, valacyclovir, or the combination for vestibular neuritis. N Engl J Med. 2004 Jul 22;351(4):354-61.</mixed-citation><mixed-citation xml:lang="en">Strupp M, Zingler VC, Arbusow V, et al. Methylprednisolone, valacyclovir, or the combination for vestibular neuritis. N Engl J Med. 2004 Jul 22;351(4):354-61.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Shupak A, Issa A, Golz A, et al. Prednisone treatment for vestibular neuritis. Otol Neurotol. 2008 Apr;29(3):368-74. doi: 10.1097/MAO.0b013e3181692804.</mixed-citation><mixed-citation xml:lang="en">Shupak A, Issa A, Golz A, et al. Prednisone treatment for vestibular neuritis. Otol Neurotol. 2008 Apr;29(3):368-74. doi: 10.1097/MAO.0b013e3181692804.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Антоненко ЛМ, Бестужева НВ, Парфенов ВА. Применение препаратов бетагистина при головокружении. Медицинский совет. 2014;(18):34-40. [Antonenko LM, Bestuzheva NV, Parfenov VA. The use of betahistine in vertigo. Meditsinskii sovet. 2014;(18):34-40. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Антоненко ЛМ, Бестужева НВ, Парфенов ВА. Применение препаратов бетагистина при головокружении. Медицинский совет. 2014;(18):34-40. [Antonenko LM, Bestuzheva NV, Parfenov VA. The use of betahistine in vertigo. Meditsinskii sovet. 2014;(18):34-40. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Parfenov VA, Golyk VA, Matsnev EI, et al. Effectiveness of betahistine (48 mg/day) in patients with vestibular vertigo during routine practice: The VIRTUOSO study. PLoS One. 2017 Mar 30;12(3):e0174114. doi: 10.1371/journal.pone.0174114. eCollection 2017.</mixed-citation><mixed-citation xml:lang="en">Parfenov VA, Golyk VA, Matsnev EI, et al. Effectiveness of betahistine (48 mg/day) in patients with vestibular vertigo during routine practice: The VIRTUOSO study. PLoS One. 2017 Mar 30;12(3):e0174114. doi: 10.1371/journal.pone.0174114. eCollection 2017.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Furman JM, Marcus DA, Balaban CD. Vestibular migraine: clinical aspects and pathophysiology. Lancet Neurol. 2013 Jul;12(7):706-15. doi: 10.1016/S1474-4422(13)70107-8.</mixed-citation><mixed-citation xml:lang="en">Furman JM, Marcus DA, Balaban CD. Vestibular migraine: clinical aspects and pathophysiology. Lancet Neurol. 2013 Jul;12(7):706-15. doi: 10.1016/S1474-4422(13)70107-8.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Maldonado Fernandez M, Birdi JS, Irving GJ, et al. Pharmacological agents for the prevention of vestibular migraine. Cochrane Database Syst Rev. 2015 Jun 21;(6):CD010600. doi: 10.1002/14651858.CD010600.pub2.</mixed-citation><mixed-citation xml:lang="en">Maldonado Fernandez M, Birdi JS, Irving GJ, et al. Pharmacological agents for the prevention of vestibular migraine. Cochrane Database Syst Rev. 2015 Jun 21;(6):CD010600. doi: 10.1002/14651858.CD010600.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Helmchen C, Klinkenstein JC, Krü ger A, et al. Structural brain changes following peripheral vestibulo-cochlear lesion may indicate multisensory compensation. J Neurol Neurosurg Psychiatry. 2011 Mar;82(3):309-16. doi: 10.1136/jnnp.2010.204925. Epub 2010 Aug 27.</mixed-citation><mixed-citation xml:lang="en">Helmchen C, Klinkenstein JC, Krü ger A, et al. Structural brain changes following peripheral vestibulo-cochlear lesion may indicate multisensory compensation. J Neurol Neurosurg Psychiatry. 2011 Mar;82(3):309-16. doi: 10.1136/jnnp.2010.204925. Epub 2010 Aug 27.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Brown KE, Whitney SL, Marchetti GF, et al. Physical therapy for central vestibular dysfunction. Arch Phys Med Rehabil. 2006 Jan;87(1):76-81.</mixed-citation><mixed-citation xml:lang="en">Brown KE, Whitney SL, Marchetti GF, et al. Physical therapy for central vestibular dysfunction. Arch Phys Med Rehabil. 2006 Jan;87(1):76-81.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Mathog RH, Peppard SB. Exercise and recovery from vestibular injury. Am J Otolaryngol. 1982 Nov-Dec;3(6):397-407.</mixed-citation><mixed-citation xml:lang="en">Mathog RH, Peppard SB. Exercise and recovery from vestibular injury. Am J Otolaryngol. 1982 Nov-Dec;3(6):397-407.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">McDonnell MN, Hillier SL. Vestibular rehabilitation for unilateral peripheral vestibular dysfunction. Cochrane Database Syst Rev. 2015 Jan 13;1:CD005397. doi: 10.1002/14651858. CD005397.pub4.</mixed-citation><mixed-citation xml:lang="en">McDonnell MN, Hillier SL. Vestibular rehabilitation for unilateral peripheral vestibular dysfunction. Cochrane Database Syst Rev. 2015 Jan 13;1:CD005397. doi: 10.1002/14651858. CD005397.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Horak FB, Jones-Rycewicz C, Black FO, Shumway-Cook A. Effects of vestibular rehabilitation on dizziness and imbalance. Otolaryngol Head Neck Surg. 1992 Feb;106(2):175-80.</mixed-citation><mixed-citation xml:lang="en">Horak FB, Jones-Rycewicz C, Black FO, Shumway-Cook A. Effects of vestibular rehabilitation on dizziness and imbalance. Otolaryngol Head Neck Surg. 1992 Feb;106(2):175-80.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Yardley L, Beech S, Zander L, et al. A randomized controlled trial of exercise therapy for dizziness and vertigo in primary care. Br J Gen Pract. 1998 Apr;48(429):1136-40.</mixed-citation><mixed-citation xml:lang="en">Yardley L, Beech S, Zander L, et al. A randomized controlled trial of exercise therapy for dizziness and vertigo in primary care. Br J Gen Pract. 1998 Apr;48(429):1136-40.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Krebs DE, Gill-Body KM, Riley PO, Parker SW. Double-blind, placebo-controlled trial of rehabilitation for bilateral vestibular hypofunction: preliminary report. Otolaryngol Head Neck Surg. 1993 Oct;109(4):735-41.</mixed-citation><mixed-citation xml:lang="en">Krebs DE, Gill-Body KM, Riley PO, Parker SW. Double-blind, placebo-controlled trial of rehabilitation for bilateral vestibular hypofunction: preliminary report. Otolaryngol Head Neck Surg. 1993 Oct;109(4):735-41.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
