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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2017-4-17-25</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-791</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>Speech prosodic characteristics recorded by functional magnetic resonance imaging in healthy volunteers</article-title><trans-title-group xml:lang="ru"><trans-title>Характеристика просодии речевой системы у здоровых добровольцев, регистрируемая при помощи функциональной магнитно-резонансной томографии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карлов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karlov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра нервных болезней лечебного факультета</p><p>127473, Москва, ул. Делегатская, 20, стр.1</p></bio><bio xml:lang="en"><p>Department of Nervous System Diseases, Faculty of General Medicine</p><p>20, Delegatskaya St., Build. 1, Moscow 127473</p></bio><email xlink:type="simple">v_karlov@barnsly.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шкловский</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Shklovsky</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, Москва, Малый Кропоткинский пер., 23</p></bio><bio xml:lang="en"><p>23, Malyi Kropotkinsky Lane, Moscow 119991</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коновалов</surname><given-names>Р. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Konovalov</surname><given-names>R. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское шоссе, 80</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow 125367</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрушевский</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrushevsky</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, Москва, Малый Кропоткинский пер., 23</p></bio><bio xml:lang="en"><p>23, Malyi Kropotkinsky Lane, Moscow 119991</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Золовкина</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zolovkina</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра нервных болезней лечебного факультета</p><p>127473, Москва, ул. Делегатская, 20, стр.1</p></bio><bio xml:lang="en"><p>Department of Nervous System Diseases, Faculty of General Medicine</p><p>20, Delegatskaya St., Build. 1, Moscow 127473</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Московский государственный медико-стоматологический университет им А.И. Евдокимова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Центр патологии речи и нейрореабилитации» – Московский  научно-исследовательский институт психиатрии, филиал ФГБУ  «Федеральный медицинский исследовательский центр психиатрии и  наркологии им. В.П. Сербского» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Speech Pathology and Neurorehabilitation, Moscow Research Institute of Psychiatry, Branch, V.P. Serbsky Federal Medical Research Center of Psychiatry and Narcology, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ «Научный центр неврологии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center of Neurology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>12</day><month>12</month><year>2017</year></pub-date><volume>9</volume><issue>4</issue><fpage>17</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Karlov V.A., Shklovsky V.M., Konovalov R.N., Petrushevsky A.G., Zolovkina V.S., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Карлов В.А., Шкловский В.М., Коновалов Р.Н., Петрушевский А.Г., Золовкина В.С.</copyright-holder><copyright-holder xml:lang="en">Karlov V.A., Shklovsky V.M., Konovalov R.N., Petrushevsky A.G., Zolovkina V.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/791">https://nnp.ima-press.net/nnp/article/view/791</self-uri><abstract><p>Many mechanisms for the brain organization of speech processes remain poorly understood now.</p><sec><title>Objective</title><p>Objective: to assess the structural and functional organization of speech prosody, by applying functional magnetic resonance imaging (fMRI). This technique allows non-invasive studies of the organization of the speech system.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. Using their proposed three paradigms, the authors evaluated speech prosody in healthy volunteers. The first paradigm was aimed to determine the intonation characteristics of a sentence; the second paradigm is to study the given accentuated and non-accentuated rhythms, and the third to recognize melodies.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. In the first paradigm, there was bilateral activation of Wernicke's speech area (Brodmann's Area 22) that significantly prevailed in volume and intensity in the right hemisphere of the brain. Also, the right hemisphere predominantly showed activation of the supplementary motor region included in cytoarchitectonical Brodmann's Area 6. There was a significant activation Brodmann's Area 9 when a rhythm was determined in the right hemisphere and in Brodmann's Area 46 when melodies were recognized. The cerebellum, limbic system, subcortical structures, etc. were noted to be activated, which permits speech function to be regarded as a whole brain process.</p></sec><sec><title>Conclusion</title><p>Conclusion. The investigation has confirmed that different regions of both hemispheres of the brain are involved in the systemic organization of speech, which enables the authors to speak about the codominance of the hemispheres in respect of this function. The presented paradigms fully meet the objectives of the study and can be used to map the prosodic characteristics of speech.</p></sec></abstract><trans-abstract xml:lang="ru"><p>В настоящее время многие механизмы мозговой организации речевых процессов остаются недостаточно изученными.</p><p>Цель исследования – оценка структурно-функциональной организации речевой просодии с помощью функциональной магнитно-ре- неинвазивно исследовать организацию речевой системы.</p><sec><title>Пациенты и методы</title><p>Пациенты и методы. С помощью предложенных нами трех парадигм оценивали речевую просодию у здоровых добровольцев. Первая парадигма была направлена на определение  интонационной характеристики предложения, вторая – на изучение заданного акцентуированного и неакцентуированного ритмов, третья – на узнавание мелодии.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. При выполнении первой парадигмы наблюдалась двусторонняя активация речевой зоны Вернике (поле Бродмана 22), значительно  превалировавшая по объему и интенсивности в правом полушарии головного мозга. Также,  преимущественно в правом полушарии, отмечена активация дополнительной моторной  области, включенной в цитоархитектоническое поле Бродмана 6. При определении ритма в  правом полушарии достоверно активировалось поле Бродмана 9, а во время узнавания мелодии – поле Бродмана 46. Отмечена активация мозжечка, лимбической системы,  подкорковых структур и др., что позволяет рассматривать речевую функцию как целостный мозговой процесс.</p></sec><sec><title>Заключение</title><p>Заключение. Исследование подтвердило участие в системной организации речи различных отделов обоих полушарий головного мозга, что позволяет говорить о содоминантности  полушарий по данной функции. Представленные парадигмы полностью отвечают задачам исследования и могут использоваться для картирования просодических характеристик речи.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>функциональная магнитно-резонансная томография</kwd><kwd>просодия речи</kwd><kwd>речевая парадигма</kwd><kwd>правое полушарие</kwd></kwd-group><kwd-group xml:lang="en"><kwd>functional magnetic resonance imaging</kwd><kwd>speech prosody</kwd><kwd>verbal paradigm</kwd><kwd>right hemisphere</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Карлов ВА, Шкловский ВМ, Золовкина ВС. Развитие представлений об организации речевой системы. Журнал неврологии и психиатрии им. С.С. Корсакова. 2017;(5): 4-8. [Karlov VA, Shklovskii VM, Zolovkina VS. The development of ideas about the organization of the speech system. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2017;(5):4-8. 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