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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2017-2-58-64</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-748</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Antiplatelet therapy strategies for ischemic stroke</article-title><trans-title-group xml:lang="ru"><trans-title>Стратегии антитромботической терапии при ишемическом инсульте</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимова</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimova</surname><given-names>M. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское шоссе, 80</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow 125367 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фонякин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fonyakin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское шоссе, 80</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow 125367 </p></bio><email xlink:type="simple">fonyakin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гераскина</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Geraskina</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское шоссе, 80</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow 125367 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр неврологии», Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Neurology Research Institute, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>02</day><month>07</month><year>2017</year></pub-date><volume>9</volume><issue>2</issue><fpage>58</fpage><lpage>64</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Maksimova M.Y., Fonyakin A.V., Geraskina L.A., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Максимова М.Ю., Фонякин А.В., Гераскина Л.А.</copyright-holder><copyright-holder xml:lang="en">Maksimova M.Y., Fonyakin A.V., Geraskina L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/748">https://nnp.ima-press.net/nnp/article/view/748</self-uri><abstract><p>The paper considers the key areas of antithrombotic platelet therapy for ischemic stroke (IS). Antithrombotic therapy is shown to be a multistep and multidisciplinary strategy of treatment for patients with IS that begins with the first symptoms of the disease and continues throughout life. Each stage, including fibrinolytic therapy, early administration of antiplatelet and anticoagulant drugs, and personalized antithrombotic prevention of recurrent cerebral disorders, is important in itself and serves a single goal. Untimately, all efforts should be aimed at reducing mortality rates in the acute phase of stroke and the functional dependence of a patient and at preventing venous thromboses, recurrent stroke, and all cardiovascular events to increase the duration and quality of life. Fibrinolytic therapy increases the patient's chances for a full neurological recovery and improves the quality of later life. Antiplatelet drugs reduce the risk of cardiovascular death, early recurrences of stroke, and recurrent noncardioembolic stroke. Parenteral anticoagulants in acute stroke decrease the risk of venous thrombosis/thromboembolism, oral anticoagulants reduce that of recurrent cardioembolic stroke.</p></abstract><trans-abstract xml:lang="ru"><p>В статье рассмотрены ключевые направления антитромботической терапии при ишемическом инсульте (ИИ). Показано, что антитромботическая терапия представляет собой многоступенчатую и мультидисциплинарную стратегию лечения больных с ИИ, которое начинается с появления первых симптомов заболевания и продолжается в течение всей жизни. Каждый этап, включая проведение фибринолитической терапии, раннее назначение антитромбоцитарных и антикоагулянтных препаратов, осуществление персонифицированной антитромботической профилактики повторных церебральных нарушений, важен сам по себе и служит единой цели. В итоге все усилия должны быть направлены на уменьшение летальности в острой фазе инсульта, функциональной зависимости пациента, профилактику венозных тромбозов, повторного инсульта, всех сердечно-сосудистых осложнений для увеличения продолжительности и улучшения качества жизни. Фибринолитическая терапия повышает шансы больного на полное неврологическое восстановление и улучшение качества последующей жизни. Антитромбоцитарные препараты уменьшают риск сердечно-сосудистой смерти, ранних рецидивов инсульта и повторного некардиоэмболического инсульта. Парентеральные антикоагулянты в остром периоде инсульта снижают вероятность венозных тромбозов/тромбоэмболий, пероральные антикоагулянты – риск повторного кардиоэмболического инсульта.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемический инсульт</kwd><kwd>антитромботическая терапия</kwd><kwd>профилактика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ischemic stroke</kwd><kwd>antiplatelet therapy</kwd><kwd>prevention</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Суслина ЗА, Пирадов МА, редакторы. Инсульт: диагностика, лечение, профилактика. Москва: МЕДпресс-информ; 2009. 288 с. [Suslina ZA, Piradov MA, editors. Insul't: diagnostika, lechenie, profilaktika [Stroke: diagnostics, treatment, prevention]. Moscow: MEDpress-inform; 2009. 288p.]</mixed-citation><mixed-citation xml:lang="en">Суслина ЗА, Пирадов МА, редакторы. 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