nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2017-1-42-49nnp-696Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИThe triple synergy of ethylmethylhydroxypyridine succinate, magnesium, and vitamin B6: Molecular mechanismsТройственный синергизм этилметилгидроксипиридина сукцината, магния и витамина В6: молекулярные механизмыГромоваО. А.GromovaO. A.

153000, Иваново, Шереметевский пр., 8

8, Sheremetevsky Passage., Ivanovo 153000

unesco.gromova@gmail.comКалачеваА. Г.KalachevaA. G.

153000, Иваново, Шереметевский пр., 8

8, Sheremetevsky Passage., Ivanovo 153000

ТоршинИ. Ю.TorshinI. Yu.

141700, Московская область, Долгопрудный, Институтский пер., 9

9, Institutsky Lane, Dolgoprudnyi, Moscow Region 141700

ГришинаТ. Р.GrishinaT. R.

153000, Иваново, Шереметевский пр., 8

8, Sheremetevsky Passage., Ivanovo 153000

ТомиловаИ. К.TomilovaI. K.

153000, Иваново, Шереметевский пр., 8

8, Sheremetevsky Passage., Ivanovo 153000

ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава РоссииРоссияIvanovo State Medical Academy, Ministry of Health of RussiaRussian FederationФГБОУ ВО «Московский физико-технический институт»РоссияMoscow Institute of Physics and TechnologyRussian Federation201727032017914249Copyright © Gromova O.A., Kalacheva A.G., Torshin I.Y., Grishina T.R., Tomilova I.K., 20172017Громова О.А., Калачева А.Г., Торшин И.Ю., Гришина Т.Р., Томилова И.К.Gromova O.A., Kalacheva A.G., Torshin I.Y., Grishina T.R., Tomilova I.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/696Objective

Objective: to evaluate the triple effect of ethylmethylhydroxypyridine succinate (EMHPS), organic magnesium salt (magnesium lactate), and vitamin B6 (pyridoxine).

Material and methods

Material and methods. A systematic analysis of the molecular mechanisms of the triple synergic action of EMHPS, magnesium, and vitamin B6 was carried out. For chemoinformational analysis, the investigators developed a new mathematical method based on the combinatorial theory of solvability, which allows one to obtain quantitative estimates of the affinity constants of proteome proteins.

Results

Results. The pharmacological effects of the EMHPS molecule characterized by nootropic and antioxidant properties are shown to work in synergy with magnesium and vitamin B6. A systematic analysis of synergy interactions indicated 46 biological roles, in which the synergy of EMHPS, magnesium, and pyridoxine could be manifested. The main goals of this synergy are to protect neurons from damage, by combating excitotoxicity in the cells and to neutralize excess homocysteine (to reduce the risk of ischemic and thrombotic stroke, myocardial infarction, and coronary heart disease); to improve cognitive functions and neuromuscular transmission, to reduce anxiety, by activating acetylcholine, GABA, and dopamine receptors; to normalize lipid and glucose metabolism, by lowering hyperglycemia and improving the processing of fats.

Цель исследования – оценка тройственного эффекта этилметилгидроксипиридина сукцината (ЭМГПС), органической соли магния (лактат магния) и витамина В6 (пиридоксин).

Материал и методы

Материал и методы. Проведен систематический анализ молекулярных механизмов тройственного синергидного действия ЭМГПС, магния и витамина В6. Для хемоинформационного анализа был разработан новый математический метод, основанный на комбинаторной теории разрешимости, позволяющий получить количественные оценки значений констант сродства к белкам протеома.

Результаты

Результаты. Фармакологические эффекты молекулы ЭМГПС, характеризующейся ноотропными и антиоксидантными свойствами, осуществляются в синергизме с магнием и витамином В6. Систематический анализ синергидных взаимодействий указал на наличие 46 биологических ролей, в осуществлении которых может проявляться синергизм ЭМГПС, магния и пиридоксина. Основными аспектами такого синергизма являются: защита нейронов от повреждения за счет противодействия эксайтотоксичности клеток и обезвреживание избытка гомоцистеина (снижение риска развития ишемического и тромботического инсульта, инфаркта миокарда, ишемической болезни сердца); улучшение когнитивных функций, нейромышечной передачи, уменьшение тревоги за счет активации рецепторов ацетилхолина, ГАМК1 и дофамина; нормализация метаболизма липидов и глюкозы благодаря снижению гипергликемии и улучшению переработки жиров.

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The authors declare that there are no conflicts of interest present.