nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2016-4-62-64nnp-674Research ArticleREVIEWSОБЗОРЫROLE OF S100 PROTEIN IN THE PATHOGENESIS OF PAIN SYNDROMESРОЛЬ БЕЛКА S100 В ПАТОГЕНЕЗЕ БОЛЕВЫХ СИНДРОМОВСимхесЮ. В.SimkhesYu. V.

1355000, Ставрополь, ул. Тухачевского 17

17, Tukhachevsky St., Stavropol 355000

КарповС. М.KarpovS. M.

355017, Ставрополь, ул. Мира, 310

10, Mir St., Stavropol 355017  

БатуринВ. А.BaturinV. A.

355017, Ставрополь, ул. Мира, 310

10, Mir St., Stavropol 355017  

ВышловаИ. А.VyshlovaA.

Ирина Андреевна Вышлова.

355017, Ставрополь, ул. Мира, 310, irisha2801@yandex.ru

Irina Andreevna Vyshlova.

10, Mir St., Stavropol 355017, irisha2801@yandex.ru 

irisha2801@yandex.ruГородская клиническая больница скорой медицинской помощи города СтаврополяРоссияStavropol City Clinical Emergency HospitalRussian FederationСтавропольский государственный медицинский университетРоссияStavropol State Medical UniversityRussian Federation201616122016846264Copyright © Simkhes Y.V., Karpov S.M., Baturin V.A., Vyshlova .A., 20162016Симхес Ю.В., Карпов С.М., Батурин В.А., Вышлова И.А.Simkhes Y.V., Karpov S.M., Baturin V.A., Vyshlova .A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/674

The review presents clinical and experimental data on the interaction between the nervous and immune systems during various systemic and inflammatory processes. It reflects the specificity of immune surveillance in the structures of the nervous system. The structural characteristics and varieties of S100 protein are shown. The role of S100 calcium-binding proteins as mediators of an inflammatory response and their participation in the mechanisms of pain syndrome are reflected.

В обзоре представлены клинические и экспериментальные данные о взаимодействии нервной и иммунной систем в рамках различных системных и воспалительных процессов. Отражена специфика иммунного надзора в структурах нервной системы. Показаны структурные особенности и разновидности белка S100. Отражены роль кальций-связывающих белков S100 как посредников воспалительного ответа и их участие в механизмах болевого синдрома.

белок S100дорсопатияхронический болевой синдромS100 proteindorsopathychronic pain syndromeReferencesMerskey H, Bogduk N, editors. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. 2nd ed. Seattle: IASP Press; 1994. 222 p.Merskey H, Bogduk N, editors. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. 2nd ed. Seattle: IASP Press; 1994. 222 p.Дамулин ИВ. Особенности депрессии при неврологических заболеваниях. ЖурналДамулин ИВ. Особенности депрессии при неврологических заболеваниях. Журналневрологии и психиатрии им. С.С. Корсакова. 2005;(10):55-6. [Damulin IV. Features of depression in neurological diseases. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2005;(10):55-6. (In Russ.)].неврологии и психиатрии им. С.С. Корсакова. 2005;(10):55-6. [Damulin IV. Features of depression in neurological diseases. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2005;(10):55-6. (In Russ.)].Кукушкин МЛ. Хроническая боль. Неврология, нейропсихиатрия, психосоматика. 2010;2(3):80-6. [Kukushkin ML. Chronic pain. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, neuropsychiatry, psychosomatics. 2010;2(3):80-6. (In Russ.)]. DOI:10.14412/2074-2711-2010-107.Кукушкин МЛ. Хроническая боль. Неврология, нейропсихиатрия, психосоматика. 2010;2(3):80-6. [Kukushkin ML. Chronic pain. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, neuropsychiatry, psychosomatics. 2010;2(3):80-6. (In Russ.)]. DOI:10.14412/2074-2711-2010-107.Вышлова ИА, Карпов СМ, Стародубцев АИ. Нейроиммунологические механизмы формирования хронического болевого синдрома. Неврология, нейропсихиатрия, психосоматика. 2016;8(2):113-6. [Vyshlova IA,Karpov SM, Starodubtsev AI. Neuroimmunological mechanisms of chronic pain syndrome. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2016;8(2):113-116. (In Russ.)]. DOI:10.14412/2074-2711-2016-2-113-116.Вышлова ИА, Карпов СМ, Стародубцев АИ. Нейроиммунологические механизмы формирования хронического болевого синдрома. Неврология, нейропсихиатрия, психосоматика. 2016;8(2):113-6. [Vyshlova IA,Karpov SM, Starodubtsev AI. Neuroimmunological mechanisms of chronic pain syndrome. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2016;8(2):113-116. (In Russ.)]. DOI:10.14412/2074-2711-2016-2-113-116.Малашхия ЮА, Надарешвили ЗГ, Малашхия НЮ, Малашхия ВЮ. Мозг как орган иммунитета. Журнал неврологии и психиатрии им. С.С. Корсакова. 1999;99(9):62-3. [Malashkhiya YuA, Nadareshvili ZG, Malashkhiya NYu, Malashkhiya VYu. The brain as the organ of immunity. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 1999;99(9):62-3. (In Russ.)].Малашхия ЮА, Надарешвили ЗГ, Малашхия НЮ, Малашхия ВЮ. Мозг как орган иммунитета. Журнал неврологии и психиатрии им. С.С. Корсакова. 1999;99(9):62-3. [Malashkhiya YuA, Nadareshvili ZG, Malashkhiya NYu, Malashkhiya VYu. The brain as the organ of immunity. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 1999;99(9):62-3. (In Russ.)].Сепиашвили РИ. Иммунная система мозга и спинномозговой жидкости. Аллергология и иммунология. 2013;14(4):241–53. [Sepiashvili RI. The immune system of the brain and cerebrospinal fluid. Allergologiya i immunologiya. 2013;14(4):241-53. (In Russ.)].Сепиашвили РИ. Иммунная система мозга и спинномозговой жидкости. Аллергология и иммунология. 2013;14(4):241–53. [Sepiashvili RI. The immune system of the brain and cerebrospinal fluid. Allergologiya i immunologiya. 2013;14(4):241-53. (In Russ.)].Миронов СП, Ветрилэ СТ, Космиади ГА, Швец ВВ. Роль клеток иммунной системы в дегенеративных изменениях межпозвонкового диска. Вестник травматологии и ортопедии. 2007;(3):16-22. [Mironov SP, Vetrile ST, Kosmiadi GA, Shvets VV. The role of immune system cells in degenerative changes in the intervertebral disc. Vestnik travmatologii i ortopedii. 2007;(3):16-22. (In Russ.)].Миронов СП, Ветрилэ СТ, Космиади ГА, Швец ВВ. Роль клеток иммунной системы в дегенеративных изменениях межпозвонкового диска. Вестник травматологии и ортопедии. 2007;(3):16-22. [Mironov SP, Vetrile ST, Kosmiadi GA, Shvets VV. The role of immune system cells in degenerative changes in the intervertebral disc. Vestnik travmatologii i ortopedii. 2007;(3):16-22. (In Russ.)].Brisby H, Olmarker K, Larsson K, et al. Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica. Eur Spine J. 2002 Feb;11(1):62-6.Brisby H, Olmarker K, Larsson K, et al. Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica. Eur Spine J. 2002 Feb;11(1):62-6.Moore B, Mc Gregor D. Chromatographic and electrophoretic fraction of soluble protein of brain and liver. J Biol Chem. 1965;240(4): 1642-53.Moore B, Mc Gregor D. Chromatographic and electrophoretic fraction of soluble protein of brain and liver. J Biol Chem. 1965;240(4): 1642-53.Heizmann CW, Fritz G, Schö fer BW. S100 proteins: structure, functions and pathology. Front Biosci. 2002 May 1;7:d1356-68.Heizmann CW, Fritz G, Schö fer BW. S100 proteins: structure, functions and pathology. Front Biosci. 2002 May 1;7:d1356-68.Marenholz I, Heizmann CW, Fritz G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem Biophys Res Commun. 2004 Oct 1;322(4):1111-22.Marenholz I, Heizmann CW, Fritz G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem Biophys Res Commun. 2004 Oct 1;322(4):1111-22.Муравьев ЮВ, Лебедева ВВ. Кальцийсвязывающие белки при ревматических заболеваниях. Научно-практическая ревматология. 2012;50(1):60-4. [Murav'ev YuV, Lebedeva VV. Calcium-binding proteins in rheumatic diseases. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2012;50(1):60-4. (In Russ.)]. DOI: 10.14412/1995-4484-2012-506Муравьев ЮВ, Лебедева ВВ. Кальцийсвязывающие белки при ревматических заболеваниях. Научно-практическая ревматология. 2012;50(1):60-4. [Murav'ev YuV, Lebedeva VV. Calcium-binding proteins in rheumatic diseases. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2012;50(1):60-4. (In Russ.)]. DOI: 10.14412/1995-4484-2012-506Клюшник ТП, Стаховская ЛВ, Шерстнев ВВ и др. Роль аутоиммунных механизмов в повреждающем действии церебральной ишемии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2001;(1):46-54. [Klyushnik TP, Stakhovskaya LV, Sherstnev VV, et al. Role in autoimmune mechanismsdamaging effect of cerebral ischemia. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2001;(1):46-54. (In Russ.)].Клюшник ТП, Стаховская ЛВ, Шерстнев ВВ и др. Роль аутоиммунных механизмов в повреждающем действии церебральной ишемии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2001;(1):46-54. [Klyushnik TP, Stakhovskaya LV, Sherstnev VV, et al. Role in autoimmune mechanismsdamaging effect of cerebral ischemia. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2001;(1):46-54. (In Russ.)].Нечунаева ЕВ, Шумахер ГИ, Воробьёва ЕН и др. Иммунобиохимические показатели в ранней диагностике хронической ишемии головного мозга. Бюллетень сибирской медицины. 2011; (2):142–6. [Nechunaeva EV, Shumakher GI, Vorob'eva EN, et al. Immunal and biochemical indexes in early diagnostics of chronic brain ischemia. Byulleten' sibirskoi meditsiny. 2011;(2):142-6. (In Russ.)].Нечунаева ЕВ, Шумахер ГИ, Воробьёва ЕН и др. Иммунобиохимические показатели в ранней диагностике хронической ишемии головного мозга. Бюллетень сибирской медицины. 2011; (2):142–6. [Nechunaeva EV, Shumakher GI, Vorob'eva EN, et al. Immunal and biochemical indexes in early diagnostics of chronic brain ischemia. Byulleten' sibirskoi meditsiny. 2011;(2):142-6. (In Russ.)].Pagano RL, Mariano M, Giorgi R. Neutrophilic cell-free exudate induces antinociception mediate by the protein S100A9. Mediators Inflamm. 2006;2006(4):36765.Pagano RL, Mariano M, Giorgi R. Neutrophilic cell-free exudate induces antinociception mediate by the protein S100A9. Mediators Inflamm. 2006;2006(4):36765.Paccola CC, Gutierrez VP, Longo I, et al. Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain. Peptides. 2008 Oct;29(10):1806-14. DOI: 10.1016/j.peptides.2008.05.023.Paccola CC, Gutierrez VP, Longo I, et al. Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain. Peptides. 2008 Oct;29(10):1806-14. DOI: 10.1016/j.peptides.2008.05.023.Dale CS, Altier C, Cenac N, et al. Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition. Fundam Clin Pharmacol. 2009 Aug;23(4):427-38. DOI: 10.1111/j.1472-8206.2009.00686.x.Dale CS, Altier C, Cenac N, et al. Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition. Fundam Clin Pharmacol. 2009 Aug;23(4):427-38. DOI: 10.1111/j.1472-8206.2009.00686.x.Vogl T, Tenbrock K. Ludwig S. Mrp8 and Mrp14 are endogenous activators of Tollike receptor 4, promoting lethal, endotoxininduced shock. Nat Med. 2007 Sep;13(9): 1042-9. Epub 2007 Sep 2.Vogl T, Tenbrock K. Ludwig S. Mrp8 and Mrp14 are endogenous activators of Tollike receptor 4, promoting lethal, endotoxininduced shock. Nat Med. 2007 Sep;13(9): 1042-9. Epub 2007 Sep 2.Cheng P, Corzo CA, Luetteke N, et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med. 2008;205(10):2235-49. DOI: 10.1084/jem.20080132.Cheng P, Corzo CA, Luetteke N, et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med. 2008;205(10):2235-49. DOI: 10.1084/jem.20080132.Gebhardt C, NОmeth J, Angel P, Hess J. S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 2006 Nov 30;72(11): 1622-31. Epub 2006 Jul 17.Gebhardt C, NОmeth J, Angel P, Hess J. S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 2006 Nov 30;72(11): 1622-31. Epub 2006 Jul 17.Hermani A, De Servi B, Medunjanin S, et al. S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells. Exp Cell Res. 2006 Jan 15;312(2): 184-97. Epub 2005 Nov 17.Hermani A, De Servi B, Medunjanin S, et al. S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells. Exp Cell Res. 2006 Jan 15;312(2): 184-97. Epub 2005 Nov 17.Srikrishna G. S100A8 and S100A9: New Insights into Their Roles in Malignancy. J Innate Immun. 2012;4(1):31-40. DOI: 10.1159/000330095Srikrishna G. S100A8 and S100A9: New Insights into Their Roles in Malignancy. J Innate Immun. 2012;4(1):31-40. DOI: 10.1159/000330095Mahler EA, Zweers MC, van Lent PL, et al. Scand Association between serum levels of the proinflammatory protein S100A8/A9 and clinical and structural characteristics of patients with established knee, hip, and hand osteoarthritis. J Rheumatol. 2015;44(1):56-60. DOI: 10.3109/03009742.2014.918176.Mahler EA, Zweers MC, van Lent PL, et al. Scand Association between serum levels of the proinflammatory protein S100A8/A9 and clinical and structural characteristics of patients with established knee, hip, and hand osteoarthritis. J Rheumatol. 2015;44(1):56-60. DOI: 10.3109/03009742.2014.918176.Pagano RL, Moraes NF, De Lorenzo BH, et al. Inhibition of macrophage functions by the C-terminus of murine S100A9 is dependent on B-1 cells. Mediators Inflamm. 2014;2014:836491. DOI: 10.1155/2014/836491Pagano RL, Moraes NF, De Lorenzo BH, et al. Inhibition of macrophage functions by the C-terminus of murine S100A9 is dependent on B-1 cells. Mediators Inflamm. 2014;2014:836491. DOI: 10.1155/2014/836491Vora AN, Bonaca MP, Ruff CT, et al. Diagnostic evaluation of the MRP-8/14 for the emergency assessment of chest pain. J Thromb Thrombolysis. 2012 Aug;34(2):229-34. DOI: 10.1007/s11239-012-0705-y.Vora AN, Bonaca MP, Ruff CT, et al. Diagnostic evaluation of the MRP-8/14 for the emergency assessment of chest pain. J Thromb Thrombolysis. 2012 Aug;34(2):229-34. DOI: 10.1007/s11239-012-0705-y.Schaub N, Reichlin T, Meune C, et al. Markers of plaque instability in the early diagnosis and risk stratification of acute myocardial infarction. Clin Chem. 2012 Jan;58(1):246-56. DOI: 10.1373/clinchem.2011.172940.Schaub N, Reichlin T, Meune C, et al. Markers of plaque instability in the early diagnosis and risk stratification of acute myocardial infarction. Clin Chem. 2012 Jan;58(1):246-56. DOI: 10.1373/clinchem.2011.172940.Bealer JF, Colgin M. S100A8/A9: a potential new diagnostic aid for acute appendicitis. Acad Emerg Med. 2010 Mar;17(3):333-6. DOI: 10.1111/j.1553-2712.2010.00663.x.Bealer JF, Colgin M. S100A8/A9: a potential new diagnostic aid for acute appendicitis. Acad Emerg Med. 2010 Mar;17(3):333-6. DOI: 10.1111/j.1553-2712.2010.00663.x.Kienhorst LB, van Lochem E, Kievit W, et al. Gout Is a Chronic Inflammatory Disease in Which High Levels of Interleukin-8 (CXCL8), Myeloid-Related Protein 8/Myeloid-Related Protein 14 Complex, and an Altered Proteome Are Associated With Diabetes Mellitus and Cardiovascular Disease. Arthritis Rheumatol. 2015 Dec;67(12):3303-13. doi: 10.1002/art.39318.Kienhorst LB, van Lochem E, Kievit W, et al. Gout Is a Chronic Inflammatory Disease in Which High Levels of Interleukin-8 (CXCL8), Myeloid-Related Protein 8/Myeloid-Related Protein 14 Complex, and an Altered Proteome Are Associated With Diabetes Mellitus and Cardiovascular Disease. Arthritis Rheumatol. 2015 Dec;67(12):3303-13. doi: 10.1002/art.39318.Mitchell K, Yang HY, Tessier PA, et al. Localization of S100A8 and S100A9 expressing neutrophils to spinal cord during peripheral tissue inflammation. Pain. 2008 Jan;134(1-2): 216-31. Epub 2007 Dec 11.Mitchell K, Yang HY, Tessier PA, et al. Localization of S100A8 and S100A9 expressing neutrophils to spinal cord during peripheral tissue inflammation. Pain. 2008 Jan;134(1-2): 216-31. Epub 2007 Dec 11.

The authors declare that there are no conflicts of interest present.