nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2016-2-107-112nnp-617Research ArticleREVIEWSОБЗОРЫThe role of frontal-subcortical circuits in the development of obsessive-compulsive disordersРоль лобно-подкорковых связей в развитии обсессивно-компульсивных расстройствКутлубаевМ. А.KutlubaevM. A.

Отделение неврологии

кафедра неврологии с курсами нейрохирургии и медицинской генетики 

450005, ул. Достоевского,132, Уфа, Башкортостан

450000, Республика Башкортостан, Уфа, ул. Ленина, 3

Department of Neurology

Department of Neurology with Courses of Neurosurgery and Medical Genetics

132, Dostoevsky St., Ufa 450005, Bashkortostan

3, Lenin St., Ufa 450000, Bashkortostan 

mansur.kutlubaev@yahoo.comРеспубликанская клиническая больница им. Г.Г. Куватова, Уфа; ГБОУ ВПО «Башкирский государственный медицинский университет» Минздрава России, УфаРоссияG.G. Kuvatov Republican Clinical Hospital, Ufa; Bashkir State Medical University, Ministry of Health of Russia, UfaRussian Federation20161607201682107112Copyright © Kutlubaev M.A., 20162016Кутлубаев М.А.Kutlubaev M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/617

The paper presents a concise review of investigations into the role of impaired frontal-subcortical circuits in the development of obsessive-compulsive disorder (OCD). It gives data on the frequency of neurosis-like symptoms of the OCD spectrum in neurological diseases.

The development of OCD is associated with an imbalance between the activity of the direct (activating) and indirect (inhibitory) pathways of the cortico-striatal-thalamo-cortical feedback loop. These data are confirmed by the results of neuroimaging and neuropsychological studies in patients with OCD. The frequency of OCD symptoms is high in organic brain lesions. OCP may be a manifestation of neurological diseases so their timely detection is an important aspect of a neurologist's work. The treatment of patients with neurosis-like disorders of the OCD spectrum within neurological diseases requires a multidisciplinary approach with the participation of a neurologist, a psychiatrist/psychotherapist, and a psychologist. It is necessary to combine pathogenetic treatment of the underlying disease and its neurosis-like manifestations. 

Представлен краткий обзор исследований, посвященных роли нарушений лобно-подкорковых связей в развитии обсессивно-компульсивного расстройства (ОКР). Приведены данные о частоте неврозоподобных симптомов спектра ОКР при неврологических заболеваниях.

Развитие ОКР связано с нарушением баланса между активностью прямого (активирующего) и непрямого (тормозящего) путей корково-стрио-таламо-корковой петли обратной связи. Эти данные подтверждаются результатами нейровизуализационных и нейропсихологических исследований пациентов с ОКР. Высока частота симптомов ОКР при органических поражениях головного мозга. ОКР могут быть проявлением неврологических заболеваний, поэтому их своевременное выявление – важный аспект работы невролога. Лечение пациентов с неврозоподобными расстройствами спектра ОКР в рамках неврологических заболеваний требует мультдисциплинарного подхода с участием невролога, психиатра/психотерапевта, психолога. Необходимо сочетание патогенетического лечения основного заболевания и его неврозоподобных проявлений. 

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The authors declare that there are no conflicts of interest present.