nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2016-2-87-93nnp-614Research ArticleREVIEWSОБЗОРЫNeurometabolic therapy in the recovery period of ischemic stroke: impact on quality of life and cognitive functionsНейрометаболическая терапия в восстановительном периоде ишемического инсульта: влияние на качество жизни и когнитивные функцииЗахаровВ. В.ZakharovV. V.

Кафедра нервных болезней и нейрохирургии 

119021, Москва, ул. Россолимо, 11

Department of Nervous System Diseases and Neurosurgery

11, Rossolimo St., Moscow 119021 

zakharovenator@gmail.comВахнинаН. В.VakhninaN. V.

Кафедра нервных болезней и нейрохирургии 

119021, Москва, ул. Россолимо, 11

Department of Nervous System Diseases and Neurosurgery

11, Rossolimo St., Moscow 119021 

ГромоваД. О.GromovaD. O.

Кафедра нервных болезней и нейрохирургии 

119021, Москва, ул. Россолимо, 11

Department of Nervous System Diseases and Neurosurgery

11, Rossolimo St., Moscow 119021 

ГБОУ ВПО «Первый Московский государственный медицинский универститет им. И.М. Сеченова» Минздрава России, МоскваРоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, MoscowRussian Federation201616072016828793Copyright © Zakharov V.V., Vakhnina N.V., Gromova D.O., 20162016Захаров В.В., Вахнина Н.В., Громова Д.О.Zakharov V.V., Vakhnina N.V., Gromova D.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/614

Some recovery of impaired neurological functions (a stroke recovery period) is almost always observed within the first 6–24 months after ischemic stroke (IS). The paper discusses the mechanisms responsible for this process (neurogenesis, neuroplasticity, and readaptation) and possible approaches to the drug support of cerebral reparative processes. It presents data on the rate and etiology of poststroke cognitive impairments (CI) that are one of the important factors that negatively influence the outcome of rehabilitation measures. The results obtained from a recent study of the efficacy of the neurometabolic agent citicoline in the recovery period of IS are given. The use of citicoline is shown to cause a significant regression of CI and to improve quality of life in patients who have sustained IS for the first time. 

В первые 6–24 мес после ишемического инсульта (ИИ) почти всегда наблюдается некоторое восстановление нарушенных неврологических функций (восстановительный период инсульта). В статье обсуждаются механизмы, обусловливающие данный процесс (нейрогенез, нейропластичность, реадаптация) и возможные подходы к медикаментозной поддержке церебральных репаративных процессов. Представлены данные о частоте и этиологии постинсультных когнитивных нарушений (КН), которые являются одним из важных факторов, негативно влияющим на исход реабилитационных мероприятий. Приведены результаты недавнего исследования эффективности нейрометаболического препарата цитиколина в восстановительном периоде ИИ. Показано, что на фоне использования цитиколина отмечаются достоверный регресс КН и улучшение качества жизни пациентов, впервые перенесших ИИ. 

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The authors declare that there are no conflicts of interest present.