nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2016-1-90-95nnp-589Research ArticleREVIEWSОБЗОРЫRole of lipoprotein (a) in the development of ischemic stroke and other cardiovascular diseasesРоль липопротеина (а) в развитии ишемического инсульта и других сердечно-сосудистых заболеванийПизовН. А.PizovN. A.

Кафедра неврологии и медицинской генетики с курсом нейрохирургии

Department of Neurology and Medical Genetics with Course of Neurosurgery

ПизоваН. В.PizovaN. V.

Кафедра неврологии и медицинской генетики с курсом нейрохирургии

Department of Neurology and Medical Genetics with Course of Neurosurgery

pizova@yandex.ruГБОУ ВПО «Ярославский государственный медицинский университет» Минздрава России, Ярославль, Россия 150000, Ярославль, ул. Революционная, 5РоссияYaroslavl State Medical University, Ministry of Health of Russia, Yaroslavl, Russia 5, Revolyutsionnaya St., Yaroslavl 150000Russian Federation201622032016819095Copyright © Pizov N.A., Pizova N.V., 20162016Пизов Н.А., Пизова Н.В.Pizov N.A., Pizova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/589

The paper gives the data available in the literature on the role of a level of elevated lipoprotein (a) (Lp (a)) in the development of ischemic stroke and other cardiovascular diseases. It shows the normal level of Lp (a) and the typical distribution of its concentration for people of European origin and representatives of other races. There is evidence on the genetic determination and variability of the Apo (a) gene. The paper presents the results of the recent large survey of 8000 patients with coronary heart disease and 8000 control persons, which has studied candidate genes for cardiovascular diseases. It indicates the role of Lp (a) as a risk factor for early atherosclerosis and describes main pathomorphological mechanisms. The propositions that it is necessary to screen Lp (a) in different risk groups, its target level, and possible methods for correcting the elevated Lp (a) level are given.

Представлены данные литературы о роли повышенного уровня липопротеина (а) – Лп (а) – в развитии ишемического инсульта и других сердечно-сосудистых заболеваний. Показаны нормальный уровень ЛП (а), а также типичное распределение концентрации Лп (а) для лиц европейского происхождения и представителей других рас. Приведены данные о генетической детерминированности и вариабельности гена Апо (а). Представлены результаты недавно проведенного крупного исследования, включавшего 8000 больных с ишемической болезнью сердца и 8000 лиц контрольной группы, в котором изучали гены-кандидаты для сердечно-сосудистых заболеваний. Показана роль Лп (а) как фактора риска возникновения раннего атеросклероза и описаны основные патоморфологические механизмы. Приведены положения о необходимости скрининга Лп (а) в различных группах риска, целевой уровень и возможные методы коррекции повышенного уровня Лп (а).

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The authors declare that there are no conflicts of interest present.