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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2016-1-22-28</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-578</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>Comparative clinical characteristics of depression in bipolar affective disorders types I and II</article-title><trans-title-group xml:lang="ru"><trans-title>Сравнительная характеристика клинических особенностей депрессии при биполярном аффективном расстройстве I и II типа</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тювина</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tyuvina</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра психиатрии и наркологии</p></bio><bio xml:lang="en"><p>Department of Psychiatry and Narcology</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коробкова</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Korobkova</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра психиатрии и наркологии</p></bio><bio xml:lang="en"><p>Department of Psychiatry and Narcology</p></bio><email xlink:type="simple">korobkova_i@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России, Москва, Россия 119021, Москва, ул. Россолимо, 11, стр. 9</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia 11, Rossolimo St., Build. 9, Moscow 119021</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>21</day><month>03</month><year>2016</year></pub-date><volume>8</volume><issue>1</issue><fpage>22</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Tyuvina N.A., Korobkova I.G., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Тювина Н.А., Коробкова И.Г.</copyright-holder><copyright-holder xml:lang="en">Tyuvina N.A., Korobkova I.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/578">https://nnp.ima-press.net/nnp/article/view/578</self-uri><abstract><sec><title>Objective</title><p>Objective: to investigate the clinical features of depression within bipolar affective disorders types I and II (BADI and BADII).</p></sec><sec><title>Patients and methods</title><p>Patients and methods. An examination was made in 100 depressive patients, including 25 with BADI, 37 with BADII, and 38 with recurrent depressive disorder (RDD) (a comparison group). The patients' status was evaluated in accordance with the ICD-10 and DSM-V affective disorder criteria, by using a specially developed questionnaire.</p></sec><sec><title>Results</title><p>Results. BAD-related depression has features distinguishing it from RDD: sexual preference (men); an earlier age of disease onset; a shorter duration, but a higher frequency of exacerbations; a greater tendency for the continuum; a more marked decrease in social and family adaptation; development in people with predominantly hyperthymic premorbid; more frequently a family history of affective disorders, schizophrenia, and alcoholism; high comorbidity with metabolic diseases and psychoactive substance abuse; worse health more commonly in autumn and winter; a predominant anxious affect and an obviously decreasing interest in the structure of depression; a higher incidence of atypical sleep, appetite, and weight disorders; high suicidal activity; higher motor retardation (in BADI); relatively small involvement of somatic complaints in BAD I and frequent panic attacks in BADII.</p></sec><sec><title>Conclusion</title><p>Conclusion. Knowledge of the specific features of BAD-related depression will be able to make a more accurate differential diagnosis and to perform more effective treatment in these patients.</p></sec></abstract><trans-abstract xml:lang="ru"><p>Цель исследования – изучение клинических особенностей депрессии в рамках биполярного аффективного расстройства (БАР) I и II типа.</p><sec><title>Пациенты и методы</title><p>Пациенты и методы. Обследовано 100 больных с депрессией, среди которых 25 страдали БАР I типа (БАР I), 37 – БАР II типа (БАР II), 38 –рекуррентным депрессивным расстройством (РДР, группа сравнения). Состояние больных оценивали в соответствии с диагностическими критериями аффективных расстройств по МКБ-10 и DSM-V с использованием специально разработанного опросника.</p></sec><sec><title>Результаты</title><p>Результаты. Депрессия при БАР имеет особенности, отличающие ее от РДР: половая предпочтительность (мужчины); более ранний возраст начала заболевания; меньшая длительность, но большая частота обострений; большая склонность к континуальному течению; более выраженное снижение социальной и семейной адаптации; развитие у лиц с преимущественно гипертимным преморбидом; более частая наследственная отягощенность по аффективным расстройствам, шизофрении и алкоголизму; высокая коморбидность с обменными заболеваниями и злоупотреблением психоактивными веществами; ухудшение состояния чаще в осенне-зимнее время; преобладающий тревожный аффект и выраженное снижение интересов в структуре депрессии; большая частота атипичных нарушений сна, аппетита и массы тела; высокий уровень суицидальной активности; более высокий уровень моторной заторможенности (при БАР I); относительно небольшая включенность соматических жалоб (при БАР I) и частое развитие панических атак (при БАР II).</p></sec><sec><title>Заключение</title><p>Заключение. Знание особенностей депрессии при БАР позволит проводить более точную дифференциальную диагностику и более эффективное лечение таких пациентов.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>биполярное аффективное расстройство</kwd><kwd>рекуррентное депрессивное расстройство</kwd><kwd>расстройства биполярного спектра</kwd><kwd>депрессия</kwd><kwd>клинические особенности</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bipolar affective disorder</kwd><kwd>recurrent depressive disorder</kwd><kwd>bipolar spectrum disorders</kwd><kwd>depression</kwd><kwd>clinical features</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Angst J, Marneros A. Bipolarity from ancient to modern times: conception, birth and rebirth. J Affect Disord. 2001 Dec;67(1-3):3-19.</mixed-citation><mixed-citation xml:lang="en">Angst J, Marneros A. 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