nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2015-4-110-115nnp-567Research ArticleREVIEWSОБЗОРЫPossibilities of using naftidrofuryl in the therapy of cerebrovascular diseases: Literature review and the authors’ observationsНафтидрофурил в терапии цереброваскулярных заболеваний: обзор литературы и собственные наблюденияБеловаА. Н.BelovaA. N.

603155, Нижний Новгород, Верхне-Волжская набережная, 18/1

18/1, Verkhne-Volzhskaya Emb., Nizhny Novgorod 603155

anbelova@mail.ruШакуроваД. Н.ShakurovaD. N.

603155, Нижний Новгород, Верхне-Волжская набережная, 21

21, Verkhne-Volzhskaya Emb., Nizhny Novgorod 603155

ГаязоваЕ. В.GayazovaE. V.

603155, Нижний Новгород, Верхне-Волжская набережная, 21

21, Verkhne-Volzhskaya Emb., Nizhny Novgorod 603155

ФГБУ «Приволжский федеральный медицинский исследовательский центр» Минздрава РоссииРоссияVolga Federal Medical Research Centre, Ministry of Health of RussiaRussian FederationГБУЗ Городская клиническая больница № 3РоссияCity Clinical Hospital ThreeRussian Federation20151501201674110115Copyright © Belova A.N., Shakurova D.N., Gayazova E.V., 20162016Белова А.Н., Шакурова Д.Н., Гаязова Е.В.Belova A.N., Shakurova D.N., Gayazova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/567

The efficacy of naftidrofuryl in treating cerebrovascular diseases is analyzed on the basis of a review of the Russian and foreign literature. Naftidrofuryl is a seroton 5-HT2 receptor antagonist and acts on brain energy metabolism mainly during hypoxia or ischemia. The results of preclinical studies proving the antispasmodic and neuroprotective properties of the drug and its capacity to normalize microcirculation in hypoxia are briefly considered. Experimental findings served as a basis for further studies of the efficacy of naftidrofuryl in patients with stroke, chronic cerebral ischemia, or vascular dementia. The use of naftidrofuryl (dusopharm) was demonstrated to statistically significantly enhance the efficiency of rehabilitation in post-stroke patients and to be followed by significant psychoemotional improvement. According to a Cochrane review, the naftidrofuryl-treated patients with vascular dementia showed a tendency towards better executive and cognitive functions, behavior, and mood. The drug was noted to have a positive effect on the health of patients with chronic cerebral ischemia.

The authors provide the data of their trial of naftidrofuryl used in patients with dyscirculatory encephalopathy, which have confirmed its efficacy in this category of patients. The data available in the literature suggest that oral naftidrofuryl has a good tolerability and safety profile in patients with cerebrovascular diseases.

На основании обзора зарубежной и отечественной литературы анализируется эффективность нафтидрофурила при цереброваскулярной патологии. Нафтидрофурил является антагонистом серотониновых 5-HT2-рецепторов и воздействует на энергетический метаболизм клеток головного мозга, преимущественно в условиях гипоксии или ишемии. Кратко рассмотрены результаты доклинических исследований препарата, доказывающие его антиспастическое и нейропротективное действие, способность нормализовать микроциркуляцию в условиях гипоксии. Экспериментальные данные послужили основанием для дальнейшего изучения эффективности нафтидрофурила при инсульте, хронической ишемии головного мозга и сосудистой деменции. Показано, что применение нафтидрофурила статистически достоверно повышало эффективность реабилитации больных, перенесших инсульт, и сопровождалось достоверным улучшением психоэмоционального состояния. Согласно данным Кохрановского обзора, у пациентов с сосудистой деменцией на фоне применения нафтидрофурила отмечалась тенденция к улучшению исполнительных и когнитивных функций, поведения, настроения. При хронической ишемии мозга отмечено позитивное влияние препарата на самочувствие больных.

Приведены собственные данные, подтверждающие эффективность препарата у пациентов с дисциркуляторной энцефалопатией. Данные литературы также свидетельствуют о хорошем профиле переносимости и безопасности при пероральном приеме нафтидрофурила у больных с цереброваскулярной патологией.

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The authors declare that there are no conflicts of interest present.