nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2015-4-65-70nnp-561Research ArticleREVIEWSОБЗОРЫSome aspects of treatment for cognitive impairments. Cyticolin: pharmacological characteristics, possible benefits, aspects of useНекоторые аспекты лечения когнитивных нарушений: цитиколин – фармакологические характеристики, возможные преимущества, аспекты примененияТрофимоваН. В.TrofimovaN. V.

Клиника нервных болезней им. А.Я. Кожевникова,

119021, Москва, ул. Россолимо, 11

A.Ya. Kozhevnikov Clinic of Nervous System Disorders,

11, Rossolimo St., Moscow 119021

ПреображенскаяИ. С.PreobrazhenskayaI. S.

Клиника нервных болезней им. А.Я. Кожевникова,

119021, Москва, ул. Россолимо, 11

A.Ya. Kozhevnikov Clinic of Nervous System Disorders,

11, Rossolimo St., Moscow 119021

irinasp2@ya.ruГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава РоссииРоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaRussian Federation201515012016746570Copyright © Trofimova N.V., Preobrazhenskaya I.S., 20162016Трофимова Н.В., Преображенская И.С.Trofimova N.V., Preobrazhenskaya I.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/561

The paper reviews the data available in the literature on the pharmacokinetic and pharmacodynamic properties of cyticolin and its use in cognitive impairments (CIs).

It assesses trials investigating the effect of cyticolin on cognitive functions, including its possible role in increasing Sirtuin 1 (SIRT1) expression. The results of the latest multicenter trials of the drug used to treat dementia syndrome are analyzed in elderly patients with clinical presentations of mental confusion (the VITA trial) and mild vascular CIs (the IDEALE trial).

Cyticolin is able to potentiate neuroplasticity and is a natural precursor of phospholipids, mainly phosphotidylcholine that serves as a source of choline in the metabolic pathways of acetylcholine biosynthesis. The VITA and IDEALE have shown that the parenteral and oral administrations of cyticolin are effective and safe in the treatment of moderate vascular CIs and dementia with clinical presentations of mental confusion. Cyticolin therapy is used to reduce the risk of side effects and to delay of loss of the therapeutic effects of levodopa preparations. Cyticolin has been noted to have a positive effect on cognitive functions in patients with Alzheimer’s disease if it is used as an additional therapy.

Обзор посвящен фармакокинетическим и фармакодинамическим свойствам цитиколина и его применению при когнитивных нарушениях (КН). Цитиколин способен потенцировать нейропластичность и является естественным предшественником фосфолипидов, главным образом фосфатидилхолина, который служит источником холина в метаболических путях биосинтеза ацетилхолина. Анализируются исследования, касающиеся влияния цитиколина на когнитивные функции, в том числе возможной роли цитиколина в повышении экспрессии сиртуина 1 (SIRT1). Приведены данные новых многоцентровых испытаний препарата при синдроме деменции у пожилых пациентов с клинической картиной спутанности сознания (VITA) и легких КН сосудистого генеза (IDEALE). Исследования VITA и IDEALE показали, что парентеральное и пероральное введение цитиколина эффективно и безопасно в лечении умеренных КН сосудистого генеза и деменции с картиной спутанности сознания. Терапия цитиколином может использоваться для снижения риска побочных эффектов и замедления утраты терапевтического эффекта препаратов леводопы. Отмечено положительное влияние цитиколина на когнитивные функции у пациентов с болезнью Альцгеймера при условии применения его в качестве средства дополнительной терапии.

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The authors declare that there are no conflicts of interest present.