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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2015-1-80-86</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-491</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Cardioembolic stroke</article-title><trans-title-group xml:lang="ru"><trans-title>Кардиоэмболический инсульт</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дамулин</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Damulin</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">damulin@mmascience.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреев</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Andreev</surname><given-names>D. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салпагарова</surname><given-names>З. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Salpagarova</surname><given-names>Z. K.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра нервных болезней и нейрохирургии ; 119021, Москва, ул. Россолимо, 11;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Nervous System Diseases and Neurosurgery; 11, Rossolimo St., Moscow 119021 </institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Кафедра неотложной и профилактической кардиологии ГБОУ ВПО «Первый Московский государственный университет им. И.М.Сеченова» Минздрава России, Москва, Россия; 119992, Москва, ул. Б. Пироговская, 6, стр. 1</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Emergency and Preventive Cardiology, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia; 6, B. Pirogovskaya St., Build. 1, Moscow 119992</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>20</day><month>03</month><year>2015</year></pub-date><volume>7</volume><issue>1</issue><fpage>80</fpage><lpage>86</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Damulin I.V., Andreev D.A., Salpagarova Z.K., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Дамулин И.В., Андреев Д.А., Салпагарова З.К.</copyright-holder><copyright-holder xml:lang="en">Damulin I.V., Andreev D.A., Salpagarova Z.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/491">https://nnp.ima-press.net/nnp/article/view/491</self-uri><abstract><p>The paper considers the main causes and pathogenetic, clinical, and therapeutic aspects of cardioembolic stroke (CES). The latter is emphasized to be a group of conditions, which is highly heterogeneous in its etiology, pathogenesis, course, and prognosis. Their major risk factors are atrial fibrillation (AF), myocardial infarction (MI), and heart valve apparatus pathology. The leading diagnostic method for CES is brain computed tomography or magnetic resonance imaging, which most commonly visualize a well-defined wedge-shaped area of ischemia on the gray and white matter boundary, as well as cardiological examination. The results of electrocardiography, among them the detection of AF or MI, and echocardiography are of key value for correct diagnosis. Patients with CES are managed by the common principles applied to ischemic stroke. Oral anticoagulants, the efficacy and safety of which have been proven in large clinical trials, are most widely used to prevent recurrent CES. The patients who are at risk for CEA must be followed up by both a cardiologist and a neurologist. Adequate and individualized therapy can substantially reduce the likelihood of cerebrovascular disorders in this category of patients. </p></abstract><trans-abstract xml:lang="ru"><p>Рассматриваются основные причины, патогенетические, клинические и терапевтические аспекты кардиэмболического инсульта (КЭИ). Подчеркивается, что КЭИ представляют собой весьма гетерогенную по этиологии, патогенезу, течению и прогнозу группу состояний. Основными факторами риска их возникновения являются фибрилляция предсердий (ФП), инфаркт миокарда (ИМ) и патология клапанного аппарата сердца. Ведущим методом диагностики при КЭИ являются компьютерная или магнитно-резонансная томография головного мозга, при которых чаще всего визуализируется четко очерченная зона ишемии клинообразной формы на границе белого и серого вещества головного мозга, а также результаты кардиологического обследования. Ключевое значение для правильной диагностики имеют результаты электрокардиографии, в частности, выявление ФП или ИМ, и эхокардиографии. Ведение больных с КЭИ проводится по общим принципам, используемым при ишемическом инсульте. Для профилактики повторных КЭИ наиболее широко используются пероральные антикоагулянты, эффективность и безопасность которых доказаны в крупных клинических исследованиях. Пациенты, у которых имеется риск возникновения КЭИ, должны наблюдаться и у кардиолога, и у невролога. Адекватная и индивидуализированная терапия позволяет существенно уменьшить вероятность сосудистых церебральных нарушений у данной категории больных. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиоэмболический инсульт</kwd><kwd>диагностика</kwd><kwd>профилактика</kwd><kwd>новые оральные антикоагулянты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardioembolic stroke</kwd><kwd>diagnosis</kwd><kwd>prevention</kwd><kwd>novel oral anticoagulants</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Babikian VL, Caplan LR. Brain embolism is a dynamic process with variable characteristics. Neurology. 2000 Feb 22;54(4):797–801.</mixed-citation><mixed-citation xml:lang="en">Babikian VL, Caplan LR. Brain embolism is a dynamic process with variable characteristics. Neurology. 2000 Feb 22;54(4):797–801.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ferro JM. Brain embolism. Answers to practical questions. J Neurol. 2003 Feb;250(2):139–47.</mixed-citation><mixed-citation xml:lang="en">Ferro JM. Brain embolism. Answers to practical questions. J Neurol. 2003 Feb;250(2):139–47.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ricci S. Embolism from the heart in the young patient: a short review. Neurol Sci. 2003 May;24 Suppl 1:S13–4.</mixed-citation><mixed-citation xml:lang="en">Ricci S. Embolism from the heart in the young patient: a short review. Neurol Sci. 2003 May;24 Suppl 1:S13–4.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Wang D, Liu M, Hao Z, Tao W. Association between reduced kidney function and clinical outcomes after ischaemic stroke with atrial fibrillation. Eur J Neurol. 2014;21(1):160–6. doi: 10.1111/ene.12293. Epub 2013 Nov 15.</mixed-citation><mixed-citation xml:lang="en">Wang D, Liu M, Hao Z, Tao W. Association between reduced kidney function and clinical outcomes after ischaemic stroke with atrial fibrillation. Eur J Neurol. 2014;21(1):160–6. doi: 10.1111/ene.12293. Epub 2013 Nov 15.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Суслина ЗА, Пирадов МА, редакторы. Инсульт: диагностика, лечение, профилактика. 2-е издание. Москва: МЕДпресс-информ; 2009. 288 с. [Suslina ZA, Piradov MA, editors. Insul't: diagnostika, lechenie, profilaktika. [Stroke: diagnosis, treatment, prevention]. 2nd edition. Moscow: MEDpressinform; 2009. 288 p.].</mixed-citation><mixed-citation xml:lang="en">Суслина ЗА, Пирадов МА, редакторы. Инсульт: диагностика, лечение, профилактика. 2-е издание. Москва: МЕДпресс-информ; 2009. 288 с. [Suslina ZA, Piradov MA, editors. Insul't: diagnostika, lechenie, profilaktika. [Stroke: diagnosis, treatment, prevention]. 2nd edition. Moscow: MEDpressinform; 2009. 288 p.].</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Широков ЕА. Профилактика инсульта: актуальные проблемы и новые тенденции. Русский медицинский журнал. 2013;(10):466–9. [Shirokov EA. Stroke prevention: current problems and new trends. Russkii meditsinskii zhurnal. 2013;(10):466–9. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Широков ЕА. Профилактика инсульта: актуальные проблемы и новые тенденции. Русский медицинский журнал. 2013;(10):466–9. [Shirokov EA. Stroke prevention: current problems and new trends. Russkii meditsinskii zhurnal. 2013;(10):466–9. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Скворцова ВИ, Евзельман МА. Ишемический инсульт. Орел: Медиа Cфера; 2006. 296 с. [Skvortsova VI, Evzel'man MA. Ishemicheskii insul't [Ischemic stroke]. Orel: Media Cfera; 2006. 296 p.].</mixed-citation><mixed-citation xml:lang="en">Скворцова ВИ, Евзельман МА. Ишемический инсульт. Орел: Медиа Cфера; 2006. 296 с. [Skvortsova VI, Evzel'man MA. Ishemicheskii insul't [Ischemic stroke]. Orel: Media Cfera; 2006. 296 p.].</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue T, Kimura K, Minematsu K, Yamaguchi T, for the Japan Multicenter Stroke Investigators’ Collaboration (J-MUSIC). Clinical features of transient ischemic attack associated with atrial fibrillation: analysis of 1084 TIA patients. J Stroke Cerebrovasc Dis. 2004 Jul-Aug;13(4):155–9.</mixed-citation><mixed-citation xml:lang="en">Inoue T, Kimura K, Minematsu K, Yamaguchi T, for the Japan Multicenter Stroke Investigators’ Collaboration (J-MUSIC). Clinical features of transient ischemic attack associated with atrial fibrillation: analysis of 1084 TIA patients. J Stroke Cerebrovasc Dis. 2004 Jul-Aug;13(4):155–9.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ueno Y, Kimura K, Iguchi Y, et al. Right-toleft shunt and lacunar stroke in patients without hypertension and diabetes. Neurology. 2007 Feb 13;68(7):528–31.</mixed-citation><mixed-citation xml:lang="en">Ueno Y, Kimura K, Iguchi Y, et al. Right-toleft shunt and lacunar stroke in patients without hypertension and diabetes. Neurology. 2007 Feb 13;68(7):528–31.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hankey GJ. Stroke. Your Questions Answered. Edinburg: Churchill Livingstone; 2002.</mixed-citation><mixed-citation xml:lang="en">Hankey GJ. Stroke. Your Questions Answered. Edinburg: Churchill Livingstone; 2002.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ay H, Koroshetz WJ, Benner T, et al. Neuroanatomic correlates of stroke-related myocardial injury. Neurology. 2006 May 9;66(9):1325–9. Epub 2006 Mar 8.</mixed-citation><mixed-citation xml:lang="en">Ay H, Koroshetz WJ, Benner T, et al. Neuroanatomic correlates of stroke-related myocardial injury. Neurology. 2006 May 9;66(9):1325–9. Epub 2006 Mar 8.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Bogousslavsky J, Cachin C, Regli F, et al. Cardiac sources of embolism and cerebral infarction – clinical consequences and vascular concomitants. Neurology. 1991 Jun;41(6):855–9.</mixed-citation><mixed-citation xml:lang="en">Bogousslavsky J, Cachin C, Regli F, et al. Cardiac sources of embolism and cerebral infarction – clinical consequences and vascular concomitants. Neurology. 1991 Jun;41(6):855–9.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Wolf PA, Dawber TR, Thomas HE, Kannel WB. Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: the Framingham study. Neurology. 1978 Oct;28(10):973–7.</mixed-citation><mixed-citation xml:lang="en">Wolf PA, Dawber TR, Thomas HE, Kannel WB. Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: the Framingham study. Neurology. 1978 Oct;28(10):973–7.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wright IS, Foley WT. Use of anticoagulants in the treatment of heart disease. Am J Med. 1947 Dec;3(6):718–39.</mixed-citation><mixed-citation xml:lang="en">Wright IS, Foley WT. Use of anticoagulants in the treatment of heart disease. Am J Med. 1947 Dec;3(6):718–39.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Stratton JR, Resnick AD. Increased embolic risk in patients with left ventricular thrombi. Circulation. 1987 May;75(5):1004–11.</mixed-citation><mixed-citation xml:lang="en">Stratton JR, Resnick AD. Increased embolic risk in patients with left ventricular thrombi. Circulation. 1987 May;75(5):1004–11.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ciaccheri M, Castelli G, Cecchi F, et al. Lack of correlation between intracavitary thrombosis detected by cross sectional echocardiography and systemic emboli in patients with dilated cardiomyopathy. Br Heart J. 1989 Jul;62(1):26–9.</mixed-citation><mixed-citation xml:lang="en">Ciaccheri M, Castelli G, Cecchi F, et al. Lack of correlation between intracavitary thrombosis detected by cross sectional echocardiography and systemic emboli in patients with dilated cardiomyopathy. Br Heart J. 1989 Jul;62(1):26–9.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Levine HJ, Pauker SG, Salzman EW. Antithrombotic therapy in valvular heart disease. Chest. 1989 Feb;95(2 Suppl):98S–106S.</mixed-citation><mixed-citation xml:lang="en">Levine HJ, Pauker SG, Salzman EW. Antithrombotic therapy in valvular heart disease. Chest. 1989 Feb;95(2 Suppl):98S–106S.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Морозова ТЕ, Андрущишина ТБ. Профилактика тромбоэмболических осложнений у пациентов с фибрилляцией предсердий. Фарматека. 2014;9(282):81–7. [Morozova TE, Andrushchishina TB. Prevention of thromboembolism in patients with atrial fibrillation. Farmateka. 2014;9(282):81–7. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Морозова ТЕ, Андрущишина ТБ. Профилактика тромбоэмболических осложнений у пациентов с фибрилляцией предсердий. Фарматека. 2014;9(282):81–7. [Morozova TE, Andrushchishina TB. Prevention of thromboembolism in patients with atrial fibrillation. Farmateka. 2014;9(282):81–7. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ашихмин ЯИ, Щекочихин ДЮ. Индивидуализированная антитромботическая терапия при фибрилляции предсердий. Фарматека. 2013;18(271):119–23. [Ashikhmin YaI, Shchekochikhin DYu. Individualized antithrombotic therapy in atrial fibrillation. Farmateka. 2013;18(271):119–23. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Ашихмин ЯИ, Щекочихин ДЮ. Индивидуализированная антитромботическая терапия при фибрилляции предсердий. Фарматека. 2013;18(271):119–23. [Ashikhmin YaI, Shchekochikhin DYu. Individualized antithrombotic therapy in atrial fibrillation. Farmateka. 2013;18(271):119–23. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Явелов ИС, редактор. Диагностика и лечение фибрилляции предсердий. Рекомендации РКО, ВНОА и АССХ, выпуск 2. Москва; 2012. 100 с. [Yavelov IS, editor. Diagnostika i lechenie fibrillyatsii predserdii. Rekomendatsii RKO, VNOA i ASSKh, vypusk 2 [Diagnosis and treatment of atrial fibrillation. Recommendations of RCS, RSAS and CVSA, 2nd issue]. Moscow; 2012. 100 p.].</mixed-citation><mixed-citation xml:lang="en">Явелов ИС, редактор. Диагностика и лечение фибрилляции предсердий. Рекомендации РКО, ВНОА и АССХ, выпуск 2. Москва; 2012. 100 с. [Yavelov IS, editor. Diagnostika i lechenie fibrillyatsii predserdii. Rekomendatsii RKO, VNOA i ASSKh, vypusk 2 [Diagnosis and treatment of atrial fibrillation. Recommendations of RCS, RSAS and CVSA, 2nd issue]. Moscow; 2012. 100 p.].</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Хасанова ДР. Ишемический инсульт. Москва: МИА; 2012. 288 с. [Parfenov VA, Khasanova DR. Ishemicheskii insul't [Ischemic stroke]. Moscow: MIA; 2012. 288 p.].</mixed-citation><mixed-citation xml:lang="en">Парфенов ВА, Хасанова ДР. Ишемический инсульт. Москва: МИА; 2012. 288 с. [Parfenov VA, Khasanova DR. Ishemicheskii insul't [Ischemic stroke]. Moscow: MIA; 2012. 288 p.].</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Вербицкая СВ. Вторичная профилактика инсульта при фибрилляции предсердий, применение апиксабана (исследования ARISTOTLE, AVERROES). Неврология, нейропсихиатрия, психосоматика. 2014; (спецвыпуск 2. Инсульт):7–14. [Parfenov VA, Verbitskaya SV. Secondary prevention of stroke in atrial fibrillation, use of apixaban: ARISTOTLE, AVERROES studies. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2014;(2s):7–14. (In Russ.)]. doi: http://dx.doi.org/10.14412/2074-27112014-2S-7-14</mixed-citation><mixed-citation xml:lang="en">Парфенов ВА, Вербицкая СВ. Вторичная профилактика инсульта при фибрилляции предсердий, применение апиксабана (исследования ARISTOTLE, AVERROES). Неврология, нейропсихиатрия, психосоматика. 2014; (спецвыпуск 2. Инсульт):7–14. [Parfenov VA, Verbitskaya SV. Secondary prevention of stroke in atrial fibrillation, use of apixaban: ARISTOTLE, AVERROES studies. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2014;(2s):7–14. (In Russ.)]. doi: http://dx.doi.org/10.14412/2074-27112014-2S-7-14</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Connolly S, Ezekowitz M, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009 Sep 17;361(12):1139–51. doi: 10.1056/NEJMoa0905561. Epub 2009 Aug 30.</mixed-citation><mixed-citation xml:lang="en">Connolly S, Ezekowitz M, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009 Sep 17;361(12):1139–51. doi: 10.1056/NEJMoa0905561. Epub 2009 Aug 30.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Eikelboom J, Weitz J. Dabigatran and risk of myocardial infarction. Nat Rev Cardiol. 2012 Mar 13;9(5):260–2. doi: 10.1038/nrcardio.2012.34.</mixed-citation><mixed-citation xml:lang="en">Eikelboom J, Weitz J. Dabigatran and risk of myocardial infarction. Nat Rev Cardiol. 2012 Mar 13;9(5):260–2. doi: 10.1038/nrcardio.2012.34.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Connolly S, Eikelboom J, Joyner C, et al. Apixaban in patients with atrial fibrillation. N Engl J Med. 2011 Mar 3;364(9):806–17. doi: 10.1056/NEJMoa1007432. Epub 2011 Feb 10.</mixed-citation><mixed-citation xml:lang="en">Connolly S, Eikelboom J, Joyner C, et al. Apixaban in patients with atrial fibrillation. N Engl J Med. 2011 Mar 3;364(9):806–17. doi: 10.1056/NEJMoa1007432. Epub 2011 Feb 10.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Granger C, Alexander J, McMurray J, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011 Sep 15;365(11):981–92. doi: 10.1056/NEJMoa1107039. Epub 2011 Aug 27.</mixed-citation><mixed-citation xml:lang="en">Granger C, Alexander J, McMurray J, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011 Sep 15;365(11):981–92. doi: 10.1056/NEJMoa1107039. Epub 2011 Aug 27.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Patel M, Mahaffey K, Garg J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011 Sep 8;365(10):883–91. doi: 10.1056/NEJMoa1009638. Epub 2011 Aug 10.</mixed-citation><mixed-citation xml:lang="en">Patel M, Mahaffey K, Garg J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011 Sep 8;365(10):883–91. doi: 10.1056/NEJMoa1009638. Epub 2011 Aug 10.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Diener HC, Connolly J, Ezekowitz M, et al. Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial. Lancet Neurol. 2010 Dec;9(12):1157–63. doi: 10.1016/S14744422(10)70274-X. Epub 2010 Nov 6.</mixed-citation><mixed-citation xml:lang="en">Diener HC, Connolly J, Ezekowitz M, et al. Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial. Lancet Neurol. 2010 Dec;9(12):1157–63. doi: 10.1016/S14744422(10)70274-X. Epub 2010 Nov 6.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Easton J, Lopes R, Bahit M, et al. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial. Lancet Neurol. 2012 Jun;11(6):503–11. doi: 10.1016/S14744422(12)70092-3. Epub 2012 May 8.</mixed-citation><mixed-citation xml:lang="en">Easton J, Lopes R, Bahit M, et al. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial. Lancet Neurol. 2012 Jun;11(6):503–11. doi: 10.1016/S14744422(12)70092-3. Epub 2012 May 8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
