nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2015-1S-22-25nnp-470Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИRisk factors for transition of febrile convulsions to epilepsyФакторы риска трансформации фебрильных судорог в эпилепсиюДолининаА. Ф.DolininaA. F.nevro@odkb74.ruГромоваЛ. Л.GromovaL. L.МухинК. Ю.MukhinK. Yu.ГБУЗ «Челябинская областная детская клиническая больница», Челябинск, Россия; 454076, Челябинск, ул. Блюхера, 42А;РоссияChelyabinsk Regional Children’s Clinical Hospital, Chelyabinsk, Russia; 42A, Blyukher St., Chelyabinsk 454076;Russian FederationГБОУ ВПО «Южно-Уральский государственный медицинский университет» Минздрава России, Челябинск, Россия; 54052, Челябинск, ул. Черкасская, 2;РоссияSouth Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia; 2, Blyukher St., Chelyabinsk 454052;Russian FederationИнститут детской неврологии и эпилепсии имени Святителя Луки, Москва, Россия; 15211, Москва, ул. Борисовские Пруды, 13, корп. 2РоссияSaint Luke’s Institute of Pediatric Neurology and Epilepsy, Moscow, Russia; 13, Borisovskie Prudy, Build. 2, Moscow 115211Russian Federation20151803201571SSpecial issue "Epilepsy"2225Copyright © Dolinina A.F., Gromova L.L., Mukhin K.Y., 20152015Долинина А.Ф., Громова Л.Л., Мухин К.Ю.Dolinina A.F., Gromova L.L., Mukhin K.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/470

Object: to assess a relationship between febrile convulsions (FC) and epilepsy. Patients and methods. The role of perinatal hereditary diseases, a family history of FC and epilepsy, as well as clinical findings and the results of supplementary studies (electroencephalography and brain magnetic resonance imaging) were analyzed in children with a history of FC. One hundred and sixty-three children with a history of FC were followed up for 8 to 12 years. Two groups of children with transition of febrile convulsions to epilepsy (n=24) and with a good outcome (n=139) were compared. Results and discussion. The findings suggest that factors, such as a family history of epilepsy, the focal pattern of FC, and neurologic changes, highly significantly affect the transformation of FC to epilepsy. Changes in epileptiform EEG activity and abnormal structural neuroimaging are markers for the high probability of transition of febrile convulsions to epilepsy.

Цель исследования – оценка взаимосвязи фебрильных судорог (ФС) и эпилепсии. Пациенты и методы. Проанализированы роль перинатальной патологии, наследственной отягощенности по ФС и эпилепсии, клинические данные и результаты дополнительных методов исследования (электроэнцефалография и магнитно-резонансная томография головного мозга) у детей, имеющих ФС в анамнезе. Проведено катамнестическое исследование 163 детей с ФС в анамнезе. Длительность катамнеза составила от 8 до 12 лет. Сопоставлены данные детей двух групп: с исходом ФС в эпилепсию (n=24) и доброкачественным исходом (n=139). Результаты и обсуждение. Полученные результаты свидетельствуют о высокой степени достоверности влияния на трансформацию ФС в эпилепсию следующих факторов: наследственной отягощенности по эпилепсии, фокального характера ФС, изменений неврологического статуса. Изменения на электроэнцефалограммах в виде эпилептиформной активности, структурные нарушения, выявленные при нейровизуализации, являются маркерами повышенной вероятности перехода ФС в эпилепсию. 

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The authors declare that there are no conflicts of interest present.