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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2014-4-26-30</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-449</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>Benign paroxysmal positional vertigo in outpatient practice: Diagnosis and treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Диагностика и лечение доброкачественного пароксизмального позиционного головокружения в амбулаторной практике</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бестужева</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bestuzheva</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">bestuzheva_nv@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Парфенов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Parfenov</surname><given-names>V. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антоненко</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Antonenko</surname><given-names>L. M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра нервных болезней и нейрохирургии лечебного факультета ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России, Москва, Россия 119435, Москва, ул. Россолимо, 11, стр.1</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Nervous System Diseases and Neurosurgery, Faculty of Therapeutics, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia; 11, Rossolimo St., Build. 1, Moscow 119435</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>10</day><month>12</month><year>2014</year></pub-date><volume>6</volume><issue>4</issue><fpage>26</fpage><lpage>30</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Bestuzheva N.V., Parfenov V.A., Antonenko L.M., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Бестужева Н.В., Парфенов В.А., Антоненко Л.М.</copyright-holder><copyright-holder xml:lang="en">Bestuzheva N.V., Parfenov V.A., Antonenko L.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/449">https://nnp.ima-press.net/nnp/article/view/449</self-uri><abstract><p>Dizziness is one of the common reasons for visits to physicians of various specialties; the data of foreign investigations show that benign paroxysmal positional vertigo (BPPV) is most frequently encountered.</p><sec><title>Objective</title><p>Objective: to study the causes of dizziness, to analyze the frequency of BPPV and the efficiency of its treatment in outpatient practice.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. The investigation enrolled 80 patients, including 55 (68.7%) women and 25 (31.3%) men, aged 18 to 75 years (mean age 53.8±12.8 years), who complained of dizziness and sought for medical advice in the Therapeutic-and-Diagnostic Unit, A.Ya. Kozhevnikov Clinic of Nervous System Diseases, I.M. Sechenov First Moscow State Medical University.</p></sec><sec><title>Results</title><p>Results. The most common causes of dizziness in outpatient practice were BPPV (46.2%) and postural phobic vertigo (35%). The diagnosis of VPPV, if special positional testing (Dix-Hallpike and McClure-Pagnini tests) was carried out, was shown to create no significant difficulties. The diagnosis was not established in the majority (97.5%) of the patients; effective treatment was performed in one of the patients. Combined treatment, by performing the positional tests and using betaserc for 2 months, led to complete resolution of positional vertigo in most (97.3%) patients.</p></sec><sec><title>Discussion</title><p>Discussion. The findings indicate the efficiency of examining patients with complaints of dizziness, by using the special otoneurological tests to detect BPPV. The purposeful questioning of patients with BPPV can suspect this disease in the majority of cases. Our investigation shows the high efficiency of rehabilitation maneuvers for BPPV, which agrees well with the data of other authors. Physicians’ poor awareness of BPPV among physicians and the high efficiency of its treatment in outpatient practice are noted.</p></sec></abstract><trans-abstract xml:lang="ru"><p>Головокружение – одна из наиболее частых причин обращения к врачам различных специальностей; по данным иностранных исследований, чаще всего встречается доброкачественное пароксизмальное позиционное головокружение (ДППГ). Цель исследования – изучение причин головокружения, анализ частоты ДППГ и эффективности его лечения в амбулаторной практике.</p><sec><title>Пациенты и методы</title><p>Пациенты и методы. В исследование было включено 80 пациентов: 55 (68,7%) женщин и 25 (31,3%) мужчин – в возрасте от 18 до 75 лет (средний возраст 53,8±12,8 года) с жалобами на головокружение, обратившихся на консультацию в лечебно-диагностическое отделение клиники нервных болезней им. А.Я. Кожевникова Первого МГМУ им. И.М. Сеченова.</p></sec><sec><title>Результаты</title><p>Результаты. Самыми частыми причинами головокружения в амбулаторной практике оказались ДППГ (46,2%) и головокружение вследствие постуральной фобической неустойчивости (35%). Показано, что диагностика ДППГ при условии выполнения специальных позиционных проб (Дикса–Холлпайка и МакКлюра–Пагнини) не вызывает значительных трудностей. У большинства (97,5%) пациентов с ДППГ не был установлен диагноз, ни одному пациенту не проводилось эффективного лечения. Комбинированное лечение с выполнением позиционных проб и прием бетасерка в течение 2 мес привели к полному регрессу позиционного головокружения у большинства (97,3%) пациентов.</p></sec><sec><title>Обсуждение</title><p>Обсуждение. Результаты проведенного исследования показали эффективность обследования пациентов с жалобами на головокружение с использованием специальных отоневрологических проб, направленных на выявление ДППГ. При целенаправленном расспросе пациентов с ДППГ в большинстве случаев удается заподозрить это заболевание. В нашем исследовании отмечена высокая эффективность реабилитационных маневров при ДППГ, что согласуется с данными других авторов. Отмечаются плохая информированность врачей о ДППГ, высокая эффективность его лечения в амбулаторной практике.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>головокружение</kwd><kwd>системное головокружение</kwd><kwd>вестибулярные расстройства</kwd><kwd>доброкачественное пароксизмальное позиционное головокружение</kwd><kwd>бетасерк</kwd><kwd>лечебный позиционный маневр</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dizziness</kwd><kwd>systemic vertigo</kwd><kwd>vestibular disorders</kwd><kwd>benign paroxysmal positional vertigo</kwd><kwd>betaserc</kwd><kwd>therapeutic positional maneuver</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Brandt T. Vertigo. Its Multicensory Syndromes. 2nd ed. London: Springer; 2000.</mixed-citation><mixed-citation xml:lang="en">Brandt T. Vertigo. Its Multicensory Syndromes. 2nd ed. London: Springer; 2000.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Brandt T, Dieterich M. Vertigo and dizziness: common complains. London: Springer; 2004. 208 p.</mixed-citation><mixed-citation xml:lang="en">Brandt T, Dieterich M. Vertigo and dizziness: common complains. London: Springer; 2004. 208 p.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Yardley L, Owen N, Nazareth I, Luxon L. Prevalence and presentation of dizziness in a general practice community sample of working age people. Br J Gen Pract. 1998;48:1131–5.</mixed-citation><mixed-citation xml:lang="en">Yardley L, Owen N, Nazareth I, Luxon L. Prevalence and presentation of dizziness in a general practice community sample of working age people. Br J Gen Pract. 1998;48:1131–5.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Davis A, Moorjani P. The epidemiology of hearing and balance disorders. In: Textbook of audiological medicine. Luxon L, Furman JM, Martini A, Stephens D, editors. London: Martin Dunitz; 2003. P. 89–99.</mixed-citation><mixed-citation xml:lang="en">Davis A, Moorjani P. The epidemiology of hearing and balance disorders. In: Textbook of audiological medicine. Luxon L, Furman JM, Martini A, Stephens D, editors. London: Martin Dunitz; 2003. P. 89–99.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Neuhauser HK, Lempert T. Vertigo: epidemiologic aspects. Semin Neurol. 2009;29(5):473–81. DOI: http://dx.doi.org/10.1055/s-0029-1241043.</mixed-citation><mixed-citation xml:lang="en">Neuhauser HK, Lempert T. Vertigo: epidemiologic aspects. Semin Neurol. 2009;29(5):473–81. DOI: http://dx.doi.org/10.1055/s-0029-1241043.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Neuhauser HK. Epidemiology of vestibular vertigo. Neurology. 2005;65:898–904. DOI: http://dx.doi.org/10.1212/01.wnl. 0000175987.59991.3d.</mixed-citation><mixed-citation xml:lang="en">Neuhauser HK. Epidemiology of vestibular vertigo. Neurology. 2005;65:898–904. DOI: http://dx.doi.org/10.1212/01.wnl. 0000175987.59991.3d.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Oghalai JS, Manolidis S, Barth JL, et al. Unrecognized benign paroxysmal positional vertigo in elderly patients. J Otolaryngol Head Neck Surg. 2000;122(5):630–4.</mixed-citation><mixed-citation xml:lang="en">Oghalai JS, Manolidis S, Barth JL, et al. Unrecognized benign paroxysmal positional vertigo in elderly patients. J Otolaryngol Head Neck Surg. 2000;122(5):630–4.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Burt CW, Schappert SM. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 1999–2000. Vital Health Stat 13. 2004;(157):1–70.</mixed-citation><mixed-citation xml:lang="en">Burt CW, Schappert SM. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 1999–2000. Vital Health Stat 13. 2004;(157):1–70.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tusa RJ. Dizziness. Med Clin N Am. 2009;93:263–71. DOI: http://dx.doi.org/10. 1016/j.mcna.2008.09.005.</mixed-citation><mixed-citation xml:lang="en">Tusa RJ. Dizziness. Med Clin N Am. 2009;93:263–71. DOI: http://dx.doi.org/10. 1016/j.mcna.2008.09.005.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Brandt T, Bronstein AM. Cervical vertigo. J Neurol Neurosur Psychiatry. 2001;71:8–12. DOI: http://dx.doi.org/10.1136/jnnp.71.1.8.</mixed-citation><mixed-citation xml:lang="en">Brandt T, Bronstein AM. Cervical vertigo. J Neurol Neurosur Psychiatry. 2001;71:8–12. DOI: http://dx.doi.org/10.1136/jnnp.71.1.8.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Fife D, FitzGerald JE. Do patients with benign paroxysmal positional vertigo receive prompt treatment? Analysis of waiting times and human and financial costs associated with current practice. Int J Audiol. 2005;44:50–7. DOI: http://dx.doi.org/10.1080/ 14992020400022629.</mixed-citation><mixed-citation xml:lang="en">Fife D, FitzGerald JE. Do patients with benign paroxysmal positional vertigo receive prompt treatment? Analysis of waiting times and human and financial costs associated with current practice. Int J Audiol. 2005;44:50–7. DOI: http://dx.doi.org/10.1080/ 14992020400022629.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Абдулина ОВ, Замерград МВ. Периферическая вестибулопатия под маской инсульта. Неврологический журнал. 2005;10(6):28–31. [Parfenov VA, Abdulina OV, Zamergrad MV. Peripheral vestibulopathy simulating a stroke. Nevrologicheskii zhurnal. 2005;10(6):28–31. (In Russ.)]</mixed-citation><mixed-citation xml:lang="en">Парфенов ВА, Абдулина ОВ, Замерград МВ. Периферическая вестибулопатия под маской инсульта. Неврологический журнал. 2005;10(6):28–31. [Parfenov VA, Abdulina OV, Zamergrad MV. Peripheral vestibulopathy simulating a stroke. Nevrologicheskii zhurnal. 2005;10(6):28–31. (In Russ.)]</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Абдулина ОВ, Замерград МВ. Дифференциальный диагноз, прогноз и лечение острого вестибулярного головокружения. Неврологический журнал. 2007;12(6):21–5.[ Parfenov VA, Abdulina OV, Zamergrad MV. Differential diagnosis, prognosis and treatment of acute vestibular vertigo.</mixed-citation><mixed-citation xml:lang="en">Парфенов ВА, Абдулина ОВ, Замерград МВ. Дифференциальный диагноз, прогноз и лечение острого вестибулярного головокружения. Неврологический журнал. 2007;12(6):21–5.[ Parfenov VA, Abdulina OV, Zamergrad MV. Differential diagnosis, prognosis and treatment of acute vestibular vertigo.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Nevrologicheskii zhurnal. 2007;12(6):21–5. (In Russ.)]</mixed-citation><mixed-citation xml:lang="en">Nevrologicheskii zhurnal. 2007;12(6):21–5. (In Russ.)]</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Parnes LS, Agrawal SK, Atlas J. Diagnosis and management of benign paroxysmal positional vertigo (BPPV). CMAJ. 2003;169:681–93.</mixed-citation><mixed-citation xml:lang="en">Parnes LS, Agrawal SK, Atlas J. Diagnosis and management of benign paroxysmal positional vertigo (BPPV). CMAJ. 2003;169:681–93.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Nedzelski JM, Barber HO, McIlmoyl L. Diagnoses in a dizziness unit. J Otolaryngol. 1986;15:101–4.</mixed-citation><mixed-citation xml:lang="en">Nedzelski JM, Barber HO, McIlmoyl L. Diagnoses in a dizziness unit. J Otolaryngol. 1986;15:101–4.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Neuhauser HK. Epidemiology of vertigo. Curr Opin Neurol. 2007;20:40–6. DOI: http://dx.doi.org/10.1097/WCO.0b013e328013f432.</mixed-citation><mixed-citation xml:lang="en">Neuhauser HK. Epidemiology of vertigo. Curr Opin Neurol. 2007;20:40–6. DOI: http://dx.doi.org/10.1097/WCO.0b013e328013f432.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Baloh RW, Honrubia V, Jacobson K. Benign positional vertigo: clinical and oculographic features in 240 cases. Neurology. 1987;37:371–8. DOI: http://dx.doi.org/10.1212/WNL.37.3.371.</mixed-citation><mixed-citation xml:lang="en">Baloh RW, Honrubia V, Jacobson K. Benign positional vertigo: clinical and oculographic features in 240 cases. Neurology. 1987;37:371–8. DOI: http://dx.doi.org/10.1212/WNL.37.3.371.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Strupp M, Dieterich M, Brandt T. The treatment and natural course of peripheral and central vertigo. Dtsch Arztebl Int. 2013;110(29–30):505–16. DOI: 10.3238/arztebl.2013.0505.</mixed-citation><mixed-citation xml:lang="en">Strupp M, Dieterich M, Brandt T. The treatment and natural course of peripheral and central vertigo. Dtsch Arztebl Int. 2013;110(29–30):505–16. DOI: 10.3238/arztebl.2013.0505.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Штульман ДР. Головокружение и нарушение равновесия. В кн.: Болезни нервной системы. Под ред. Н.Н. Яхно. Москва; 2007. С. 125–30. [Shtul'man DR. Dizziness and violation of balance. In: Bolezni nervnoi sistemy [Diseases of nervous system]. N.N. Yakhno, editor. Moscow; 2007. P. 125–30.]</mixed-citation><mixed-citation xml:lang="en">Штульман ДР. Головокружение и нарушение равновесия. В кн.: Болезни нервной системы. Под ред. Н.Н. Яхно. Москва; 2007. С. 125–30. [Shtul'man DR. Dizziness and violation of balance. In: Bolezni nervnoi sistemy [Diseases of nervous system]. N.N. Yakhno, editor. Moscow; 2007. P. 125–30.]</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Бронштейн А, Лемперт Т. Головокружение: практический подход к диагностике и лечению. Москва: ГЭОТАР; 2010. 216 с. [Bronshtein A, Lempert T. Golovokruzhenie: prakticheskii podkhod k diagnostike i lecheniyu [Dizziness: practical approach to diagnostics and treatment]. Moscow: GEOTAR; 2010. 216 p.]</mixed-citation><mixed-citation xml:lang="en">Бронштейн А, Лемперт Т. Головокружение: практический подход к диагностике и лечению. Москва: ГЭОТАР; 2010. 216 с. [Bronshtein A, Lempert T. Golovokruzhenie: prakticheskii podkhod k diagnostike i lecheniyu [Dizziness: practical approach to diagnostics and treatment]. Moscow: GEOTAR; 2010. 216 p.]</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Kerber KA, Brown DL, Lisabeth LD, et al. Stroke among patients with dizziness, vertigo, and imbalance in the emergency department: a population-based study. Stroke. 2006;37(10):2484–7. DOI: http://dx.doi.org/10.1161/01.STR.0000240329.48263.0d.</mixed-citation><mixed-citation xml:lang="en">Kerber KA, Brown DL, Lisabeth LD, et al. Stroke among patients with dizziness, vertigo, and imbalance in the emergency department: a population-based study. Stroke. 2006;37(10):2484–7. DOI: http://dx.doi.org/10.1161/01.STR.0000240329.48263.0d.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Замерград МВ. Основные проблемы диагностики и лечения вестибулярного головокружения. Неврология, нейропсихиатрия, психосоматика. 2010;(3):17–21. [Zamergrad MV. Basic problems in the diagnosis and treatment of vestibular vertigo. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2010;(3):17–21. (In Russ.)]. DOI: http://dx.doi.org/10.14412/2074-2711-2010-95.]</mixed-citation><mixed-citation xml:lang="en">Замерград МВ. Основные проблемы диагностики и лечения вестибулярного головокружения. Неврология, нейропсихиатрия, психосоматика. 2010;(3):17–21. [Zamergrad MV. Basic problems in the diagnosis and treatment of vestibular vertigo. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2010;(3):17–21. (In Russ.)]. DOI: http://dx.doi.org/10.14412/2074-2711-2010-95.]</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bhattacharyya N, Baugh RF, Orvidas L, et al. Clinical practice guideline: benign paroxysmal positional vertigo. J Otolaryngol Head Neck Surg. 2008;139(5 Suppl 4):S47–81. DOI: http://dx.doi.org/10.1016/j.otohns.2008.08.022.</mixed-citation><mixed-citation xml:lang="en">Bhattacharyya N, Baugh RF, Orvidas L, et al. Clinical practice guideline: benign paroxysmal positional vertigo. J Otolaryngol Head Neck Surg. 2008;139(5 Suppl 4):S47–81. DOI: http://dx.doi.org/10.1016/j.otohns.2008.08.022.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Epley JM. The canalith repositioning procedure: for treatment of benign paroxysmal positional vertigo. J Otolaryngol Head Neck Surg. 1992 Sep;107(3):399–404.</mixed-citation><mixed-citation xml:lang="en">Epley JM. The canalith repositioning procedure: for treatment of benign paroxysmal positional vertigo. J Otolaryngol Head Neck Surg. 1992 Sep;107(3):399–404.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bisdorff A, von Brevern M, Lempert T, Newman-Toker DE. Classification of vestibular symptoms: towards an international classification of vestibular disorders. J Vestib Res. 2009;19(1–2):1–13.</mixed-citation><mixed-citation xml:lang="en">Bisdorff A, von Brevern M, Lempert T, Newman-Toker DE. Classification of vestibular symptoms: towards an international classification of vestibular disorders. J Vestib Res. 2009;19(1–2):1–13.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Guneri EA, Kustutan O. The effects of betahistine in addition to epley maneuver in posterior canal benign paroxysmal positional vertigo. J Otolaryngol Head Neck Surg. 2012;146(1):104–8. DOI: http://dx.doi.org/10.1177/0194599811419093.</mixed-citation><mixed-citation xml:lang="en">Guneri EA, Kustutan O. The effects of betahistine in addition to epley maneuver in posterior canal benign paroxysmal positional vertigo. J Otolaryngol Head Neck Surg. 2012;146(1):104–8. DOI: http://dx.doi.org/10.1177/0194599811419093.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kulcu DG, Yanik B, Boynukalin S. Efficacy of a home-based exercise program on benign paroxysmal positional vertigo compared with betahistine. J Otolaryngol Head Neck Surg. 2008;37(3):373–9.</mixed-citation><mixed-citation xml:lang="en">Kulcu DG, Yanik B, Boynukalin S. Efficacy of a home-based exercise program on benign paroxysmal positional vertigo compared with betahistine. J Otolaryngol Head Neck Surg. 2008;37(3):373–9.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Mira E, Guidetti G, Ghilardi L, et al. Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo. Eur Arch Otorhinolaryngol. 2003;260:73–7.</mixed-citation><mixed-citation xml:lang="en">Mira E, Guidetti G, Ghilardi L, et al. Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo. Eur Arch Otorhinolaryngol. 2003;260:73–7.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Oosterveld WJ. Betahistine dihydrochloride in the treatment of vertigo of peripheral vestibular origin. A double-blind placebo-controlled study. J Laryngol Otol. 1984;98:37–41. DOI: http://dx.doi.org/10.1017/S0022215100146158.</mixed-citation><mixed-citation xml:lang="en">Oosterveld WJ. Betahistine dihydrochloride in the treatment of vertigo of peripheral vestibular origin. A double-blind placebo-controlled study. J Laryngol Otol. 1984;98:37–41. DOI: http://dx.doi.org/10.1017/S0022215100146158.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Lacour M, Sterkers O. Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action. CNS Drugs. 2001;15(11):853–70. DOI: http://dx.doi.org/10.2165/00023210-200115110-00004.</mixed-citation><mixed-citation xml:lang="en">Lacour M, Sterkers O. Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action. CNS Drugs. 2001;15(11):853–70. DOI: http://dx.doi.org/10.2165/00023210-200115110-00004.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Толмачева ВА, Парфенов ВА. Причины головокружения у пациентов с артериальной гипертензией и его лечение. Врач. 2007;(4):49–53. [Tolmacheva VA, Parfenov VA. The dizziness reasons at patients with arterial hypertension and its treatment. Vrach. 2007;(4):49–53. (In Russ.)]</mixed-citation><mixed-citation xml:lang="en">Толмачева ВА, Парфенов ВА. Причины головокружения у пациентов с артериальной гипертензией и его лечение. Врач. 2007;(4):49–53. [Tolmacheva VA, Parfenov VA. The dizziness reasons at patients with arterial hypertension and its treatment. Vrach. 2007;(4):49–53. (In Russ.)]</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Staab JP. Chronic dizziness: the interface between psychiatry and neurootology. Curr Opin Neurol. 2006;19:41–8. DOI: http://dx.doi.org/10.1097/01.wco. 0000198102.95294.1f.</mixed-citation><mixed-citation xml:lang="en">Staab JP. Chronic dizziness: the interface between psychiatry and neurootology. Curr Opin Neurol. 2006;19:41–8. DOI: http://dx.doi.org/10.1097/01.wco. 0000198102.95294.1f.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Furman JM, Jacob RG. Psychiatric dizziness. Neurology. 1997;48:1161–6. DOI: http://dx.doi.org/10.1212/WNL.48.5.1161.</mixed-citation><mixed-citation xml:lang="en">Furman JM, Jacob RG. Psychiatric dizziness. Neurology. 1997;48:1161–6. DOI: http://dx.doi.org/10.1212/WNL.48.5.1161.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
