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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2014-2S-62-68</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-426</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Cognitive reserve and cognitive impairments: drug and nondrug treatments</article-title><trans-title-group xml:lang="ru"><trans-title>Когнитивный резерв и когнитивные нарушения: лекарственные и нелекарственные методы коррекции</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дайникова</surname><given-names>Е.И.</given-names></name><name name-style="western" xml:lang="en"><surname>Dainikova</surname><given-names>E.I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пизова</surname><given-names>Н.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pizova</surname><given-names>N.V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра неврологии и медицинской генетики с курсом нейрохирургии, ГБОУ ВПО «Ярославская государственная медицинская академия» Минздрава России, Ярославль; 150000, Ярославль, ул. Революционная, д. 5</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Neurology and Medical Genetics with Course of Neurosurgery, Yaroslavl State Medical Academy, Ministry of Health of Russia, Yaroslavl, Russia; 5, Revolutsionnaya St. Yaroslavl 150000</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>04</day><month>10</month><year>2014</year></pub-date><volume>6</volume><issue>2S</issue><issue-title>Special issue "Stroke"</issue-title><fpage>62</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Dainikova E., Pizova N., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Дайникова Е., Пизова Н.</copyright-holder><copyright-holder xml:lang="en">Dainikova E., Pizova N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/426">https://nnp.ima-press.net/nnp/article/view/426</self-uri><abstract><p>The paper discusses concepts, such as cognitive reserve (CR) and cognitive impairments (CI). It presents the controlled and uncorrectable factors that influence CR and considers the factors of increasing CR and reducing the risk of dementia. The mechanisms responsible for the development of vascular CIs and the role of vascular factor in the occurrence of neurodegenerative disease, primarily Alzheimer's disease and Parkinson's disease, are covered. The issues of correcting CIs in cerebrovascular and neurodegenerative diseases are discussed. The conception of CR is shown to be of value in the planning of management tactics for each patient to prevent dementia by drug and non-drug treatments.</p></abstract><trans-abstract xml:lang="ru"><p>В статье обсуждаются такие понятия, как когнитивный резерв (КР) и когнитивные нарушения (КН). Представлены управляемые и некорригируемые факторы, влияющие на состояние когнитивного резерва. Рассмотрены факторы повышения КР и снижения риска развития деменции. Освещены механизмы развития сосудистых КН и роль сосудистого фактора в возникновении нейродегенеративных заболеваний, в первую очередь болезни Альцгеймера и болезни Паркинсона. Обсуждаются вопросы коррекции КН при цереброваскулярной и нейродегенеративной патологии. Показано значение концепции КР для планирования тактики ведения каждого пациента с целью профилактики деменции с использованием лекарственных и нелекарственных методов.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>когнитивный резерв</kwd><kwd>когнитивные нарушения</kwd><kwd>лекарственные и нелекарственные методы коррекции</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cognitive reserve</kwd><kwd>cognitive impairments</kwd><kwd>drug and nondrug treatments</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. 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