nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2014-2-44-50nnp-394Research ArticleREVIEWSОБЗОРЫDabigatran etexilate for nonvalvular atrial fibrillation in real practice and promises for its use to prevent strokeДабигатрана этексилат при неклапанной фибрилляции предсердий в реальной практике и перспективы его применения для профилактики инсультаФонякинА.В.FonyakinA.V.fonyakin@mail.ruФГБУ «Научный центр неврологии» РАМН, МоскваРоссияNeurology Research Center, Russian Academy of Medical Sciences, MoscowRussian Federation201419062014624450Copyright © Fonyakin A., 20142014Фонякин А.Fonyakin A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/394

The capabilities of antithrombotic therapy to prevent thromboembolic events in nonvalvular atrial fibrillation (AF) are substantially extended after designing and clinically introducing new oral anticoagulants, one of which is dabigatran. A wealth of world clinical experience with dabigatran has confirmed its efficacy and safety provided that all recommendations for dosage regimens are followed. The universal properties of the drug can hope that the indications for its use will be extended and will not be confined to the prevention and treatment of venous and atrial thromboses and thromboembolisms. Whether dabigatran may be used in acute myocardial infarction and coronary stenting in the presence of nonvalvular AF, left ventricular thrombosis, and cardiomyopathies is being considered today.

Возможности антитромботической терапии для профилактики тромбоэмболических осложнений при неклапанной фибрилляции (ФП) существенно расширились после разработки и внедрения в клиническую практику новых оральных антикоагулянтов, одним из которых является дабигатран. Богатый мировой опыт клинического применения дабигатрана подтвердил его эффективность и безопасность при условии соблюдения всех рекомендаций по режиму дозирования. Универсальные качества препарата позволяют надеяться, что показания к его применению будут расширены и не ограничатся профилактикой и лечением венозных и предсердных тромбозов и тромбоэмболий. На сегодняшний день рассматривается возможность применения дабигатрана при остром инфаркте миокарда и коронарном стентировании на фоне неклапанной ФП, при тромбозах левого желудочка, кардиомиопатиях.

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The authors declare that there are no conflicts of interest present.