nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2009-45nnp-31Research ArticlePHARMACOTHERAPYФАРМАКОТЕРАПИЯB-GROUP VITAMINS IN THE TREATMENT OF NERVOUS SYSTEM DISEASESВитамины группы В в лечении заболеваний нервной системыСтарчинаЮ. А.StarchinaYu. A.yul-starchina@yandex.ruММА им. И.М. СеченоваРоссияI.M. Sechenov Moscow Medical AcademyRussian Federation20091406200912NO2 (2009)8487Copyright © Starchina Y.A., 20092009Старчина Ю.А.Starchina Y.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/31

The paper considers the role of B-group vitamins in nervous system performance and the possibilities of their use in the treatment of nervous system diseases as solo drugs in mono- and polyneuropathies of varying genesis and in pain syndromes. The prospects for using the vitamin complex Neurobin are discussed.

Охарактеризована роль витаминов группы В в деятельности нервной системы, возможности их использования в качестве самостоятельных лекарственных препаратов при лечении заболеваний нервной системы: моно- и полиневропатий различного генеза, болевых синдромов и др. Обсуждаются перспективы применения комплексного витаминного препарата нейробион

тиаминпиридоксинцианокобаламинполиневропатииболевой синдромнейробионthiaminepyridoxinecyancobalaminepolyneuropathypain syndromeNeurobinReferences<div><p>Луцкий И.С., Лютикова Л.В., Луцкий Е.И. Витамины группы В в неврологической практике. Междунар. неврол. журн. 2008; 2:89-93.</p><p>Ba A. Metabolic and structural role of thiamine in nervous tissues. Cell Mol Neurobiol 2008; 28:923-31.</p><p>Bettendorff L., Kolb H.A., Schoffeniels E. Thiamine triphosphate activates anion channels of large unit conductance in neuroblastoma cells. J Membr Biol 1993; 136:281-28.</p><p>Gibson G.E., Blass J.P. Thiamine-dependent processes and treatment strategies in neurode- generation. Antioxid Redox Signal 2007; 9:1605-19.</p><p>Mooney S., Leuendorf J.E., Hendrickson C. et al. Vitamin B6: a long known compound of surprising complexity. Molecules 2009; 14(1):329-51.</p><p>Wilson R.G., Davis R.E. Clinical chemistry of vitamin B6. Adv Clin Chem 1983; 23:1-68.</p><p>Markle H.V. Cobalamin. Crit Rev Clin Lab Sci 1996;33:247-356.</p><p>Ахмеджанова Л.Т., Солоха О.А., Строков И.А. Витамины группы В в лечении неврологических заболеваний. РМЖ 2009; 17(11):776-83.</p><p>Данилов А.Б. Применение витаминов группы В при болях в спине: новые анальгетики? РМЖ 2008; 16:35-9.</p><p>El Otmani H., Moutaouakil F., Midafi N. et al. Cobalamin deficiency: neurological aspects in 27 cases. Rav Neurol (Paris) 2009; 165 (3):263-7.</p><p>Zambelis T., Karandreas N., Tzavellas E. et al. Large and small fiber neuropathy in chronic alcohol-dependent subject. J Periph Nerv Sys 2005; 10:375-8.</p><p>Peters T.J., Kotowicz J.F., Nyka W. et al. Treatment of alcoholic polyneuropathy with vitamin B complex: a randomized controlled trial. Alcohol and Alcoholism 2006; 41:636-42.</p><p>Gadau S., Emanueli C., Van Linthous S. et al. Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and ingibition of apoptosis. Diabetologia 2006; 49:405-20.</p><p>Mehta R., Shangari N., O.Braen P.J. Preventing cell death induced by carbonil stress, oxidative stress or mitochondrial toxins with vitamin B anti-AGE agents. Mol Nutr Food Res 2008; 52(3):379-85.</p><p>Sun Y., Lai M.S., Lu C.J. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan 2005; 14(2):48-54.</p><p>Bromm K., Herrmann W.M., Schulz H. Do the B-vitamins exhibit antinociceptive efficacy in men? Results of a placebo-controlled repeated-measures double-blind study. Neuropsychobiology 1995; 31(3):156-65.</p><p>Dordain G., Aumaitre O., Eschalier A. et al. Vitamin B12, an analgesic vitamin? Critical examination of the literature. Acta Neurol Belg 1984 Jan-Feb; 84(1):5-11.</p><p>Eckert M., Schejbal P. Therapy of neuropathies with a vitamin B combination. Symptomatic treatment of painful diseases of the peripheral nervous system with a combination preparation of thiamine, pyridoxine and cyanocobalamin. Fortschr Med 1992 Oct 20; 110(29):544-8.</p><p>Mauro G.L., Martorana U., Cataldo P. et al. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci 2000 May-Jun;4(3):53-8.</p><p>Jurna I. Analgesic and analgesia-potentiat- ing action of B vitamins. Schmerz 1998 Apr 20; 12(2):136-41.</p><p>Franca D.S., Souza A.L., Almeida K.R. et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol 2001 Jun15; 421(3):157-64.</p><p>Jurna I., Carlsson K.H., Komen W. et al. Acute effects of vitamin B6 and fixed combinations of vitamin B1, B6 and B12 on nociceptive activity evoked in the rat thalamus: doseresponse relationship and combinations with morphine and paracetamol. Klin Wochenschr 1990 Jan19; 68(2):129-35.</p><p>Wang Z.B., Gan Q., Rupert R.L. et al. Thiamine, pyridoxine, cyanocobalamin and their combination inhibit thermal, but not mechanical hyperalgesia in rats with primary sensory neuron injury. Pain 2005 Jul; 116(1-2):168-9.</p><p>Графова В.Н., Данилова Е.И. Витамины группы В (нейробион) в комплексной патогенетической терапии болевых синдромов. Организация медицинской помощи больным с болевыми синдромами. Российская научно-практическая конференция. Тезисы. Новосибирск, 1997.</p><p>Mixcoatl-Zecuatl T., Quinonez-Bastidas G.N., Caram-Salas N.L. et al. Synergistic antiallodinic interaction between gabapentin or carbamazepine and either benfotiamine or cyanocobalamin in neuropathic rats. Methods Find Exp Clin Pharmacol 2008; 30:431-41.</p><p>Kasdan M., Janes C. Carpal tunnel syndrome and vitamin B6. Plast Reconstr Surg 1987; 79:456-8.</p><p>Aufiero E., Stitic T.P., Foye P.M. et al. Pyridoxine hydrochloride treatment of carpal syndrome: a review. Nutr Res 2004; 62:96-104.</p><p>Vetter G., Bruggemann G., Lettko M. et al. Verkurzung der Diclofenac-Therapie durch B-Vitamine. Ergebnisse einer randomisierten Doppelblindstudie, Diclofenac 50 mg gegen Diclofenac 50 mg plus B-Vitamine, bei schmerzhaften Wirbelsaulenerkrankungen mit degenerativen Veranderungen. Z Rheumatol 1988; 47:351-62.</p><p>Schwieger G. Zur Frage der Rezidivprophylaxe von schmerzhaften Wrbewlsaulensyndromen durch B-Vitamine. Ergebnisse einer randomisierten Doppelblindstudie, Neurobion forte (Vitamin Bl, B6, B12) gegen Placebo. In: Klinische Bedeutung von Vitamin Bl, B6, B12 in der Schmerztherapie. N. Zollner et al. (Edtr). Darmstadt: Steinkopff Verlag, 1988; 169-81.</p></div><br /><div><p>Луцкий И.С., Лютикова Л.В., Луцкий Е.И. Витамины группы В в неврологической практике. Междунар. неврол. журн. 2008; 2:89-93.</p><p>Ba A. Metabolic and structural role of thiamine in nervous tissues. Cell Mol Neurobiol 2008; 28:923-31.</p><p>Bettendorff L., Kolb H.A., Schoffeniels E. Thiamine triphosphate activates anion channels of large unit conductance in neuroblastoma cells. J Membr Biol 1993; 136:281-28.</p><p>Gibson G.E., Blass J.P. Thiamine-dependent processes and treatment strategies in neurode- generation. Antioxid Redox Signal 2007; 9:1605-19.</p><p>Mooney S., Leuendorf J.E., Hendrickson C. et al. Vitamin B6: a long known compound of surprising complexity. Molecules 2009; 14(1):329-51.</p><p>Wilson R.G., Davis R.E. Clinical chemistry of vitamin B6. Adv Clin Chem 1983; 23:1-68.</p><p>Markle H.V. Cobalamin. Crit Rev Clin Lab Sci 1996;33:247-356.</p><p>Ахмеджанова Л.Т., Солоха О.А., Строков И.А. Витамины группы В в лечении неврологических заболеваний. РМЖ 2009; 17(11):776-83.</p><p>Данилов А.Б. Применение витаминов группы В при болях в спине: новые анальгетики? РМЖ 2008; 16:35-9.</p><p>El Otmani H., Moutaouakil F., Midafi N. et al. Cobalamin deficiency: neurological aspects in 27 cases. Rav Neurol (Paris) 2009; 165 (3):263-7.</p><p>Zambelis T., Karandreas N., Tzavellas E. et al. Large and small fiber neuropathy in chronic alcohol-dependent subject. J Periph Nerv Sys 2005; 10:375-8.</p><p>Peters T.J., Kotowicz J.F., Nyka W. et al. Treatment of alcoholic polyneuropathy with vitamin B complex: a randomized controlled trial. Alcohol and Alcoholism 2006; 41:636-42.</p><p>Gadau S., Emanueli C., Van Linthous S. et al. Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and ingibition of apoptosis. Diabetologia 2006; 49:405-20.</p><p>Mehta R., Shangari N., O.Braen P.J. Preventing cell death induced by carbonil stress, oxidative stress or mitochondrial toxins with vitamin B anti-AGE agents. Mol Nutr Food Res 2008; 52(3):379-85.</p><p>Sun Y., Lai M.S., Lu C.J. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan 2005; 14(2):48-54.</p><p>Bromm K., Herrmann W.M., Schulz H. Do the B-vitamins exhibit antinociceptive efficacy in men? Results of a placebo-controlled repeated-measures double-blind study. Neuropsychobiology 1995; 31(3):156-65.</p><p>Dordain G., Aumaitre O., Eschalier A. et al. Vitamin B12, an analgesic vitamin? Critical examination of the literature. Acta Neurol Belg 1984 Jan-Feb; 84(1):5-11.</p><p>Eckert M., Schejbal P. Therapy of neuropathies with a vitamin B combination. Symptomatic treatment of painful diseases of the peripheral nervous system with a combination preparation of thiamine, pyridoxine and cyanocobalamin. Fortschr Med 1992 Oct 20; 110(29):544-8.</p><p>Mauro G.L., Martorana U., Cataldo P. et al. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci 2000 May-Jun;4(3):53-8.</p><p>Jurna I. Analgesic and analgesia-potentiat- ing action of B vitamins. Schmerz 1998 Apr 20; 12(2):136-41.</p><p>Franca D.S., Souza A.L., Almeida K.R. et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol 2001 Jun15; 421(3):157-64.</p><p>Jurna I., Carlsson K.H., Komen W. et al. Acute effects of vitamin B6 and fixed combinations of vitamin B1, B6 and B12 on nociceptive activity evoked in the rat thalamus: doseresponse relationship and combinations with morphine and paracetamol. Klin Wochenschr 1990 Jan19; 68(2):129-35.</p><p>Wang Z.B., Gan Q., Rupert R.L. et al. Thiamine, pyridoxine, cyanocobalamin and their combination inhibit thermal, but not mechanical hyperalgesia in rats with primary sensory neuron injury. Pain 2005 Jul; 116(1-2):168-9.</p><p>Графова В.Н., Данилова Е.И. Витамины группы В (нейробион) в комплексной патогенетической терапии болевых синдромов. Организация медицинской помощи больным с болевыми синдромами. Российская научно-практическая конференция. Тезисы. Новосибирск, 1997.</p><p>Mixcoatl-Zecuatl T., Quinonez-Bastidas G.N., Caram-Salas N.L. et al. Synergistic antiallodinic interaction between gabapentin or carbamazepine and either benfotiamine or cyanocobalamin in neuropathic rats. Methods Find Exp Clin Pharmacol 2008; 30:431-41.</p><p>Kasdan M., Janes C. Carpal tunnel syndrome and vitamin B6. Plast Reconstr Surg 1987; 79:456-8.</p><p>Aufiero E., Stitic T.P., Foye P.M. et al. Pyridoxine hydrochloride treatment of carpal syndrome: a review. Nutr Res 2004; 62:96-104.</p><p>Vetter G., Bruggemann G., Lettko M. et al. Verkurzung der Diclofenac-Therapie durch B-Vitamine. Ergebnisse einer randomisierten Doppelblindstudie, Diclofenac 50 mg gegen Diclofenac 50 mg plus B-Vitamine, bei schmerzhaften Wirbelsaulenerkrankungen mit degenerativen Veranderungen. Z Rheumatol 1988; 47:351-62.</p><p>Schwieger G. Zur Frage der Rezidivprophylaxe von schmerzhaften Wrbewlsaulensyndromen durch B-Vitamine. Ergebnisse einer randomisierten Doppelblindstudie, Neurobion forte (Vitamin Bl, B6, B12) gegen Placebo. In: Klinische Bedeutung von Vitamin Bl, B6, B12 in der Schmerztherapie. N. Zollner et al. (Edtr). Darmstadt: Steinkopff Verlag, 1988; 169-81.</p></div><br />

The authors declare that there are no conflicts of interest present.