nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2026-2-85-92nnp-2820Research ArticleREVIEWSОБЗОРЫSulpiride (Eglonil) in the treatment of somatoform and anxiety disorders. A review of the literatureСульпирид (Эглонил) в терапии соматоформных и тревожных расстройств. Обзор литературыhttps://orcid.org/0000-0003-1613-2510ДороженокИ. Ю.DorozhenokI. Yu.

Игорь Юрьевич Дороженок

Институт клинической медицины им. Н.В. Склифосовского

119991; ул. Трубецкая, 8, стр. 2; Москва

Igor Yuryevich Dorozhenok

N.V. Sklifosovsky Institute of Clinical Medicine

119991; 8, Trubetskaya St., Build 2; Moscow

dorozhenok_i_yu@staff.sechenov.ruhttps://orcid.org/0009-0004-3878-5314ЙовичС.JovicS.

Институт клинической медицины им. Н.В. Склифосовского

119991; ул. Трубецкая, 8, стр. 2; Москва

N.V. Sklifosovsky Institute of Clinical Medicine

119991; 8, Trubetskaya St., Build 2; Moscow

https://orcid.org/0000-0003-3619-206XКорякинД. А.KoriakinD. A.

Институт клинической медицины им. Н.В. Склифосовского

119991; ул. Трубецкая, 8, стр. 2; Москва

N.V. Sklifosovsky Institute of Clinical Medicine

119991; 8, Trubetskaya St., Build 2; Moscow

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияFirst Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Russian Federation2026240420261828592Copyright © Dorozhenok I.Y., Jovic S., Koriakin D.A., 20262026Дороженок И.Ю., Йович С., Корякин Д.А.Dorozhenok I.Y., Jovic S., Koriakin D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2820

   Sulpiride (Eglonil), the progenitor of the substituted benzamide class, has retained its clinical relevance for over half a century thanks to its unique combination of a dose-dependent spectrum of action and a high safety profile. At low and medium doses (100–400 mg/day), the drug, alongside mild neuroleptic effects, exhibits a triple anxiolytic, stimulant and somatotropic effects due to selective blockade of presynaptic dopamine D2/D3 receptors, followed by an increase in dopaminergic transmission in the mesolimbic pathways. This pharmacological profile determines sulpiride's leading role in the treatment of somatoform disorders and generalised anxiety disorder with predominant somato-vegetative symptoms, where the primary complaints are cardialgia, dyspepsia, tachycardia, hyperhidrosis and polymorphic bodily sensations without an organic basis. Sulpiride (Eglonil) is the drug of choice for somatised forms of anxiety, comorbidity with somatic diseases, functional disorders of the gastrointestinal tract and somatoform disorders.

   Сульпирид (Эглонил), родоначальник группы замещенных бензамидов, сохраняет клиническую релевантность более полувека благодаря уникальному сочетанию дозозависимого спектра действия и высокого профиля безопасности. В малых и средних дозах (100–400 мг/сут) препарат, наряду с мягким нейролептическим, проявляет тройственный анксиолитический, активирующий и соматотропный эффекты за счет селективной блокады пресинаптических дофаминовых D2/D3-рецепторов с последующим увеличением дофаминергической передачи в мезолимбических путях. Данный фармакологический профиль определяет ведущее место сульпирида в лечении соматоформных расстройств и генерализованного тревожного расстройства с доминированием соматовегетативной симптоматики, когда ведущими жалобами выступают кардиалгии, диспепсия, тахикардия, гипергидроз и полиморфные телесные сенсации без органической основы. Сульпирид (Эглонил) является препаратом выбора при соматизированных формах тревоги, коморбидности с соматическими заболеваниями, функциональных расстройствах желудочно-кишечного тракта и соматоформных расстройствах.

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The authors declare that there are no conflicts of interest present.