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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2025-5-113-120</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-2708</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group></article-categories><title-group><article-title>Individual selection of therapy for post-traumatic stress disorder in the paradigm of partnership with the patient, clinical case study</article-title><trans-title-group xml:lang="ru"><trans-title>Индивидуальный подбор терапии посттравматического стрессового расстройства в парадигме партнерских отношений с пациентом, случаи из практики</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5116-836X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilieva</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анна Владимировна Васильева, кафедра психотерапии, медицинской психологии и сексологии</p><p>192019, Санкт-Петербург, ул. Бехтерева, 3</p><p>191015, Санкт-Петербург, ул. Кирочная, 41</p></bio><bio xml:lang="en"><p>Anna Vladimirovna Vasilieva, Department of Psychotherapy, Medical Psychology and Sexology</p><p>3, Bekhtereva St., St. Petersburg 192019</p><p>41, Kirochnaya St., St. Petersburg 191015</p></bio><email xlink:type="simple">annavdoc@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России; ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology, Ministry of Health of Russia; I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>20</day><month>10</month><year>2025</year></pub-date><volume>17</volume><issue>5</issue><fpage>113</fpage><lpage>120</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Vasilieva A.V., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Васильева А.В.</copyright-holder><copyright-holder xml:lang="en">Vasilieva A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/2708">https://nnp.ima-press.net/nnp/article/view/2708</self-uri><abstract><p>Post-traumatic stress disorder (PTSD) is currently the focus of attention among specialists. Practitioners point to the need for thorough differ- ential diagnosis; to confirm the diagnosis, it is necessary not only to have a history of stressful exposure, but also to meet the necessary diagnostic criteria. Current real-world studies are focused on accumulating large databases of clinical cases for evaluation using machine learning and other innovative methods, as well as creating algorithms for personalized therapy. The article presents two clinical cases of PTSD associated with the death of loved ones. The first case describes the symptoms of re-experiencing associated with the loss of a spouse in a special military operation, identifies triggers that provoke the development of intrusions, and describes symptoms of psychophysiological arousal and avoidance of contact with traumatic stimuli. The process of joint decision-making with the patient on the choice of therapy in the presence of a history of negative experience with antidepressants is presented in detail. The second case is devoted to the development of PTSD due to the fact that the patient was a direct witness to the unexpected death of the important one. A detailed description of the symptoms of re-experiencing is provided, and a low level of social support, which is a significant risk factor for the development of PTSD, is highlighted. The fragmentary nature of mem ories of the traumatic event is demonstrated. Additionally, symptoms of psychophysiological arousal and avoidance are presented. In both cases, data on the dynamics of the condition during subsequent visits are provided. An algorithm for discussing the appropriate therapy with the patient is presented. In real clinical practice, the model of joint decision-making, when therapy is selected taking into account the patient's opinion, helps to significantly increase adherence to treatment.</p></abstract><trans-abstract xml:lang="ru"><p>Посттравматическое стрессовое расстройство (ПТСР) сегодня находится в центре внимания специалистов. Практические специалисты указывают на необходимость проведения тщательной дифференциальной диагностики, для подтверждения диагноза необходимо не только наличие стрессового воздействия в анамнезе, но и соответствие необходимым диагностическим критериям. Современные исследования в реальном мире направлены на аккумуляцию больших баз клинических случаев для их оценки с помощью машинного обучения и других инновационных методов, а также создания алгоритмов персонализированной терапии. В статье представлены два клинических случая ПТСР, связанных со смертью близких людей. В первом случае описываются симптомы репереживания, связанные с потерей супруга на специальной военной операции, выделяются триггеры, провоцирующие развитие интрузий, описываются симптомы психофизиологического возбуждения и избегания контакта с травматическими стимулами. Подробно представлен процесс совместного с пациентом принятия решения о выборе терапии при наличии в анамнезе негативного опыта приема антидепрессантов. Второй случай посвящен развитию ПТСР в связи с тем, что пациент стал непосредственным свидетелем неожиданной смерти значимого для него человека. Представлено подробное описание симптомов репереживания, выделен низкий уровень социальной поддержки, являющийся важным фактором риска развития ПТСР. Продемонстрирован фрагментарный характер воспоминаний о травматическом событии. Дополнительно представлены симптомы психофизиологического возбуждения и избегания. В обоих случаях приводятся данные динамики состояния во время последующих визитов. Приводится алгоритм совместного с пациентом обсуждения подходящей для него терапии. В условиях реальной клинической практики модель совместного принятия решения, когда терапия подбирается с учетом мнения пациента, помогает существенно повысить приверженность лечению.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>посттравматическое стрессовое расстройство</kwd><kwd>тревога</kwd><kwd>психофизиологическое возбуждение</kwd><kwd>клинический случай</kwd><kwd>сетевой анализ</kwd><kwd>исследования в реальном мире</kwd><kwd>клинические рекомендации</kwd><kwd>анксиолитики</kwd><kwd>этифоксин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>post-traumatic stress disorder</kwd><kwd>anxiety</kwd><kwd>psychophysiological arousal</kwd><kwd>clinical case</kwd><kwd>network analysis</kwd><kwd>real-world studies</kwd><kwd>clinical guidelines</kwd><kwd>anxiolytics</kwd><kwd>etifoxine</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья спонсируется компанией «Биокодекс»</funding-statement><funding-statement xml:lang="en">The article is sponsored by Biocodex</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Васильева АВ. 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