nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2025-3-70-76nnp-2632Research ArticleCLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯMultiple sclerosis associated with adalimumab: a case report and systematic reviewРассеянный склероз, ассоциированный с адалимумабом: клиническое наблюдение и систематический обзорhttps://orcid.org/0000-0002-4159-500XТаппаховА. А.TappakhovA. A.

Алексей Алексеевич Таппахов

677000, Якутск, ул. Белинского, 58

Aleksey Alekseyevich Tappakhov

58, Belinskogo St., Yakutsk 677000

dralex89@mail.ruhttps://orcid.org/0000-0002-4201-8570НиколаеваТ. Я.NikolaevaT. Ya.

677000, Якутск, ул. Белинского, 58

58, Belinskogo St., Yakutsk 677000

ГороховаН. Ю.GorokhovaN. Yu.

677010, Якутск, Сергеляхское шоссе, 4

4, Sergelyakhskoye Sh., Yakutsk 677010

ОконешниковаЛ. Т.OkoneshnikovaL. T.

677010, Якутск, Сергеляхское шоссе, 4

4, Sergelyakhskoye Sh., Yakutsk 677010

ЫлаховаА. Н.YlakhovaA. N.

677010, Якутск, Сергеляхское шоссе, 4

4, Sergelyakhskoye Sh., Yakutsk 677010

https://orcid.org/0000-0002-9120-3115КонниковаЭ. Э.KonnikovaE. E.

677000, Якутск, ул. Белинского, 58

58, Belinskogo St., Yakutsk 677000

ФГАОУ ВО «Северо-Восточный федеральный университет им. М.К. Аммосова»РоссияM.K. Ammosov North-Eastern Federal UniversityRussian FederationГАУЗ Республики Саха (Якутия) «Республиканская больница №1 – Национальный центр медицины им. М.Е. Николаева»РоссияRepublican Hospital No. 1 – M.E. Nikolaev National Center of MedicineRussian Federation2025240620251737076Copyright © Tappakhov A.A., Nikolaeva T.Y., Gorokhova N.Y., Okoneshnikova L.T., Ylakhova A.N., Konnikova E.E., 20252025Таппахов А.А., Николаева Т.Я., Горохова Н.Ю., Оконешникова Л.Т., Ылахова А.Н., Конникова Э.Э.Tappakhov A.A., Nikolaeva T.Y., Gorokhova N.Y., Okoneshnikova L.T., Ylakhova A.N., Konnikova E.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2632

Yakutsk 58, Belinskogo St., Yakutsk 677000, Russia; 4, Sergelyakhskoye Sh., Yakutsk 677010, Russia

The role of medications as risk factors for the development of multiple sclerosis (MS) remains controversial, although there is a limited number of studies addressing the influence of immunomodulatory drugs, contraceptives, and antibiotics on the onset of this disease. One group of medications associated with the development of demyelinating disorders (including MS) is tumor necrosis factor alpha (TNF-α) inhibitors. The limited number of reported cases of demyelination associated with this group of drugs (specifically, adalimumab), both in domestic and international medical practice, prompted the writing of this article. It presents a clinical case of a female patient who was prescribed adalimumab for the treatment of ankylosing spondylitis and developed MS in the fourth year of the disease (second year of therapy). In addition, a systematic review is presented including 13 patients described in the literature as well as our own case report.

Роль лекарственных препаратов в качестве факторов риска развития рассеянного склероза (РС) до сих пор остается предметом споров, хотя имеется ограниченное число исследований, посвященных влиянию иммуномодулирующих препаратов, контрацептивов и антибиотиков на развитие этого заболевания. Одной из групп лекарственных препаратов, назначение которых ассоциируется с развитием демиелинизирующих заболеваний (включая РС), являются блокаторы фактора некроза опухоли α. Ограниченное число случаев развития демиелинизации на фоне приема данной группы препаратов (в частности, адалимумаба) не только в отечественной, но и в мировой практике обусловило написание настоящей статьи. В ней представлено клиническое наблюдение пациентки, которой был назначен адалимумаб для лечения анкилозирующего спондилита, а на 4-м году болезни (2-й год терапии) развился РС. Кроме того, в статье проведен систематический обзор с включением 13 пациентов, описанных в зарубежной литературе, и нашего собственного наблюдения.

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The authors declare that there are no conflicts of interest present.