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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2025-3-26-32</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-2628</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>Interrelation and mutual influence of mental health and reproductive function in women with infertility undergoing in vitro fertilization therapy</article-title><trans-title-group xml:lang="ru"><trans-title>Взаимосвязь и взаимовлияние психического состояния и репродуктивной функции женщин с бесплодием, проходящих терапию методом экстракорпорального оплодотворения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5150-4765</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаевская</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaevskaya</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ангелина Олеговна Николаевская</p><p>305041, Курск, ул. К. Маркса, 3</p></bio><bio xml:lang="en"><p>Angelina Olegovna Nikolaevskaya</p><p>3, K. Marksa St., Kursk 305041</p></bio><email xlink:type="simple">nikolaevskayaao@kursksmu.net</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5202-1407</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тювина</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tyuvina</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>1119021, Москва, ул. Россолимо, 11, стр. 9</p></bio><bio xml:lang="en"><p>11, Rossolimo St., Build. 9, Moscow 119021</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7420-9585</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балабанова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Balabanova</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>1119021, Москва, ул. Россолимо, 11, стр. 9</p></bio><bio xml:lang="en"><p>11, Rossolimo St., Build. 9, Moscow 119021</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-5829-017X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Василенко</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilenko</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>305041, Курск, ул. К. Маркса, 3</p></bio><bio xml:lang="en"><p>3, K. Marksa St., Kursk 305041</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра психиатрии и психосоматики ФГБОУ ВО «Курский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Psychiatry and Psychosomatics, Kursk State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>кафедра психиатрии и наркологии Института клинической медицины им. Н.В. Склифосовского ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Psychiatry and Narcology, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>24</day><month>06</month><year>2025</year></pub-date><volume>17</volume><issue>3</issue><fpage>26</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Nikolaevskaya A.O., Tyuvina N.A., Balabanova V.V., Vasilenko M.A., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Николаевская А.О., Тювина Н.А., Балабанова В.В., Василенко М.А.</copyright-holder><copyright-holder xml:lang="en">Nikolaevskaya A.O., Tyuvina N.A., Balabanova V.V., Vasilenko M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/2628">https://nnp.ima-press.net/nnp/article/view/2628</self-uri><abstract><p>Infertility, as an emotionally significant and psychologically traumatic factor that threatens the fulfillment of a woman's fundamental biological need for motherhood, has a negative impact on mental health. In vitro fertilization (IVF), while providing a method to overcome infertility, also entails a few neuropsychiatric challenges.</p><sec><title>Objective</title><p>Objective: to assess the dynamics of mental health and reproductive function in women with infertility undergoing IVF treatment, based on longterm follow-up.</p></sec><sec><title>Material and methods</title><p>Material and methods. The study included 190 mentally healthy women with infertility undergoing IVF treatment, observed over a two-year period. During this time, IVF led to 144 pregnancies (75.79%), of which 45 (31.25%) resulted in live births, while the majority (76.32%) remained infertile. Emotional state was assessed using the Hamilton Depression and Anxiety Rating Scales, before and after the IVF procedure.</p></sec><sec><title>Results</title><p>Results. Preexisting depression and anxiety were significant risk factors for unsuccessful IVF outcomes. Initially mild depression (63.6%) and anxiety (65.6%) were more common in women whose IVF procedures failed (p≤0.01), with these rates increasing post-failure to 69.7% and 70.7% respectively (p≤0.01). Among women with successful IVF, preexisting depression and anxiety were present in 26.7% and 33.3% respectively. Successful childbirth led to stabilization of emotional state and depression persisted in 6.7% of women and anxiety in 13.3% (p≤0.01). A successful IVF outcome was also associated with increased marital satisfaction and improved spousal relationships (p≤0.01).</p></sec><sec><title>Conclusion</title><p>Conclusion. Infertility, the burdensome diagnostic procedures and surgeries associated with it, and the psychological strain of IVF-especially after unsuccessful attempts-contribute to the development of depressive and anxiety disorders. These, in turn, negatively affect the chances of conception and pregnancy maintenance, even with assisted reproductive technologies. These psychosomatic interactions must be considered in the diagnosis of infertility and in selecting appropriate treatment strategies.</p></sec></abstract><trans-abstract xml:lang="ru"><p>Бесплодие, являющееся эмоционально значимым психотравмирующим фактором, ставящим под угрозу реализацию ведущей биологической потребности женщины в материнстве, негативно отражается на ее психическом состоянии.</p><p>Применение метода экстракорпорального оплодотворения (ЭКО), с одной стороны, способствует преодолению бесплодия, а с другой – влечет за собой целый ряд нейропсихиатрических проблем.</p><p>Цель исследования – оценить в динамике по результатам катамнеза психическое состояние и репродуктивную функцию женщин с бесплодием, проходящих лечение методом ЭКО.</p><sec><title>Материал и методы</title><p>Материал и методы. В исследование вошли 190 психически здоровых женщин с бесплодием, проходящих лечение методом ЭКО, наблюдение проводилось в течение 2 лет. За этот период в результате ЭКО возникло 144 беременности (75,79%), из которых закончились родами 45 (31,25%), а большинство (76,32%) женщин продолжали страдать бесплодием. Эмоциональное состояние оценивалось в динамике, до проведения процедуры ЭКО и по ее завершении, с использованием шкал депрессии и тревоги Гамильтона. Результаты. Наличие депрессии и тревоги до проведения процедуры ЭКО являлось фактором риска ее неблагоприятного исхода. Изначально наличие легкой депрессии (63,6% случаев) и тревоги (65,6%) чаще наблюдалось у женщин с неудачным ЭКО (p≤0,01), что, в свою очередь, способствовало ухудшению этих показателей до 69,7 и 70,7% соответственно (p≤0,01). В группе женщин с удачным исходом ЭКО изначально депрессия отмечалась у 26,7%, тревога – у 33,3%. Благополучные роды привели к стабилизации эмоционального состояния: депрессия сохранилась у 6,7% женщин, тревога – у 13,3% (p≤0,01). Благоприятный исход ЭКО в целом повышал уровень удовлетворенности браком (p≤0,01) и гармонизировал супружеские отношения.</p></sec><sec><title>Заключение</title><p>Заключение. Бесплодие, связанные с ним длительные и тягостные обследования и оперативные вмешательства, процедура ЭКО и ее неудачный исход способствуют возникновению депрессивных и тревожных нарушений, которые, в свою очередь, оказывают отрицательное влияние на возможность как зачатия, так и вынашивания беременности, в том числе с использованием вспомогательных репродуктивных технологий. Эти психосоматические механизмы необходимо учитывать при диагностике бесплодия и выборе терапевтической тактики.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>бесплодие</kwd><kwd>беременность</kwd><kwd>репродуктивный статус</kwd><kwd>экстракорпоральное оплодотворение</kwd><kwd>тревожно-депрессивные нарушения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infertility</kwd><kwd>pregnancy</kwd><kwd>reproductive status</kwd><kwd>in vitro fertilization</kwd><kwd>anxiety-depressive disorders</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bai CF, Sun JW, Li J, et al. Gender differences in factors associated with depression in infertility patients. J Adv Nurs. 2019 Dec;75(12):3515-24. doi: 10.1111/jan.14171. Epub 2019 Sep 10.</mixed-citation><mixed-citation xml:lang="en">Bai CF, Sun JW, Li J, et al. 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