nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2013-2338nnp-252Research ArticleArticlesСтатьиEmotional disorders in patients with acute ischemic strokeЭмоциональные нарушения у больных в остром периоде ишемического инсультаCharikovaInna AnatolyevnaCharikovaInna Anatolyevnatcharikova.inna@yandex.ruAkhtyamovN NAkhtyamovN Ntcharikova.inna@yandex.ruVolkovaL IVolkovaL Itcharikova.inna@yandex.ruГБОУ ВПО «Уральская государственная медицинская академия» Минздрава России, ЕкатеринбургРоссияUral State Medical Academy, Ministry of Health of Russia, YekaterinburgRussian Federation20130711201353NO3 (2013)3640Copyright © Charikova I.A., Akhtyamov N.N., Volkova L.I., 20132013Charikova I.A., Akhtyamov N.N., Volkova L.I.Charikova I.A., Akhtyamov N.N., Volkova L.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/252

Most patients with prior ischemic stroke are observed to have depressive disorders and as a consequence the loss of usual lifestyle, interests,belief in recovery.Objective: to study emotional disorders within the first 7 days after ischemic stroke and their association with the severity of the disease and the lateralization of an ischemic focus in 72 patients. Results and discussion. Patients with severe stroke were found to have maximum blood cortisol and insulin levels. There was a direct relationship of emotional-volutional disorders to the levels of cortisol and neurospecific enolase

У большинства пациентов, перенесших ишемический инсульт, наблюдаются депрессивные расстройства и, как следствие, утрата привычного образа жизни, интересов, веры в выздоровление.Цель исследования – изучение нарушений эмоциональной сферы в первые 7 дней после ишемического инсульта и их взаимосвязи со степенью тяжести заболевания и латерализацией очага ишемии у 72 пациентов.Результаты исследования и их обсуждение. У пациентов с тяжелой степенью инсульта выявлены максимальные уровни кортизола и инсулина в крови. Обнаружена прямая зависимость эмоционально-волевых расстройств от уровней кортизола и нейроспецифической енолазы.

эмоционально-волевые расстройстваишемический инсульткаротидный бассейнкортизолнейроспецифическая енолазаemotional-volitional disordersischemic strokecarotid bedcortisolneurospecific enolaseReferences<div><p>Снижение заболеваемости, смертности и инвалидности от инсультов в Российской Федерации. Под ред. Скворцовой ВИ. Москва: Литерра; 2007. 192 с. [Snizhenie zabolevaemosti, smertnosti i invalidnosti ot insul'tov v Rossiyskoy Federatsii. Pod red. Skvortsovoy VI. Moscow: Literra; 2007. 192 s.]</p><p>Kufner A, Nolte CH, Galinovic I et al. Smoking-Thrombolysis Paradox : Recanalization and Reperfusion Rates After Intravenous Tissue Plasminogen Activator in Smokers With Ischemic Stroke. Stroke. 2013 Feb;44(2):407–13. DOI: 10.1161/STROKEAHA.112.662148. Epub 2013 Jan 3.</p><p>Doll R, Peto R. Mortality in relation to smoking: 20 years’ observations on male British doctors. Br Med J. 1976;2(6051):1525–36. DOI: 10.1136%2Fbmj.2.6051.1525.</p><p>Klein IF, Lavallée C, Amarenco P Outcomes of Intravenous Recombinant Tissue Plasminogen Activator Therapy According to Gender: A Clinical Registry Study and Systematic Review. Stroke. 2009;40(6):2104–10. DOI: 10.1161/STROKEAHA.108.546325. Epub 2009 Apr 16.</p><p>Di Legge S, Saposnik G, Nilanont Y, Hachinski V. Neglecting the difference: does right or left matter in stroke outcome after thrombolysis? Stroke. 2006;37(8):2066–9. Epub 2006 Jun 22.</p><p>Grines CL, Topol EJ, O’Neill WW et al. Effect of cigarette smoking on outcome after thrombolytic therapy for myocardial infarction. Circulation. 1995;91(2):298–303. DOI: 10.1161%2F01.CIR.91.2.298.</p><p>Kirtane AJ, Martinezclark P, Rahman AM et al. Association of smoking with improved myocardial perfusion and the angiographic characterization of myocardial tissue perfusion after fibrinolytic therapy for ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2005;45(2):321–23. DOI: 10.1016%2Fj.jacc.2004.10.018.</p><p>Purcell IF, Newall N, Farrer M. Lower cardiac mortality in smokers following thrombolysis for acute myocardial infarction may be related to more effective fibrinolysis. QJM. 1999;92(6):327–33. DOI: 10.1093%2Fqjmed%2F92.6.327.</p><p>Barbash GI, White HD, Modan M et al. Significance of smoking in patients receiving thrombolytic therapy for acute myocardial infarction: experience gleaned from the International Tissue Plasminogen Activator/Streptokinase Mortality Trial. Circulation. 1993;87(1):53–8. DOI: 10.1161%2F01.CIR.87.1.53.</p><p>Newby DE, McLeod AL, Uren NG et al. Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosis. Circulation. 2001;103(15):1936–41. DOI: 10.1161%2F01.CIR.103.15.1936.</p><p>Zangerle A, Kiechl S, Spiegel M et al. Recanalization after thrombolysis in stroke patients: predictors and prognostic implications. Neurology. 2007;68(1):39–44. DOI: 10.1212%2F01.wnl.0000250341.38014.d2.</p><p>Vaidyula VR, Rao AK, Mozzoli M et al. Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand. Diabetes. 2006;55(1):202–8. DOI: 10.2337%2Fdiabetes.55.01.06.db05-1026.</p><p>Lemkes BA, Hermanides J, Devries JH et al. Hyperglycemia: a prothrombotic factor? J ThrombHaemost. 2010;8(8):1663–9. DOI: 10.1111/j.1538-7836.2010.03910.x. Epub 2010 May 12.</p><p>Pandolfi A, Giaccari A, Cilli C et al. Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat. Acta Diabetol. 2001;38(2):71–6. DOI: 10.1007%2Fs005920170016.</p><p>Парфенов ВА, Хасанова ДР. Ишемический инсульт. Москва: МИА; 2012. 288 с. [Parfenov VA, Khasanova DR. Ishemicheskiy insul't. Moskva: MIA; 2012. 288 p.]</p></div><br /><div><p>Снижение заболеваемости, смертности и инвалидности от инсультов в Российской Федерации. Под ред. Скворцовой ВИ. Москва: Литерра; 2007. 192 с. [Snizhenie zabolevaemosti, smertnosti i invalidnosti ot insul'tov v Rossiyskoy Federatsii. Pod red. Skvortsovoy VI. Moscow: Literra; 2007. 192 s.]</p><p>Kufner A, Nolte CH, Galinovic I et al. Smoking-Thrombolysis Paradox : Recanalization and Reperfusion Rates After Intravenous Tissue Plasminogen Activator in Smokers With Ischemic Stroke. Stroke. 2013 Feb;44(2):407–13. DOI: 10.1161/STROKEAHA.112.662148. Epub 2013 Jan 3.</p><p>Doll R, Peto R. Mortality in relation to smoking: 20 years’ observations on male British doctors. Br Med J. 1976;2(6051):1525–36. DOI: 10.1136%2Fbmj.2.6051.1525.</p><p>Klein IF, Lavallée C, Amarenco P Outcomes of Intravenous Recombinant Tissue Plasminogen Activator Therapy According to Gender: A Clinical Registry Study and Systematic Review. Stroke. 2009;40(6):2104–10. DOI: 10.1161/STROKEAHA.108.546325. Epub 2009 Apr 16.</p><p>Di Legge S, Saposnik G, Nilanont Y, Hachinski V. Neglecting the difference: does right or left matter in stroke outcome after thrombolysis? Stroke. 2006;37(8):2066–9. Epub 2006 Jun 22.</p><p>Grines CL, Topol EJ, O’Neill WW et al. Effect of cigarette smoking on outcome after thrombolytic therapy for myocardial infarction. Circulation. 1995;91(2):298–303. DOI: 10.1161%2F01.CIR.91.2.298.</p><p>Kirtane AJ, Martinezclark P, Rahman AM et al. Association of smoking with improved myocardial perfusion and the angiographic characterization of myocardial tissue perfusion after fibrinolytic therapy for ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2005;45(2):321–23. DOI: 10.1016%2Fj.jacc.2004.10.018.</p><p>Purcell IF, Newall N, Farrer M. Lower cardiac mortality in smokers following thrombolysis for acute myocardial infarction may be related to more effective fibrinolysis. QJM. 1999;92(6):327–33. DOI: 10.1093%2Fqjmed%2F92.6.327.</p><p>Barbash GI, White HD, Modan M et al. Significance of smoking in patients receiving thrombolytic therapy for acute myocardial infarction: experience gleaned from the International Tissue Plasminogen Activator/Streptokinase Mortality Trial. Circulation. 1993;87(1):53–8. DOI: 10.1161%2F01.CIR.87.1.53.</p><p>Newby DE, McLeod AL, Uren NG et al. Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosis. Circulation. 2001;103(15):1936–41. DOI: 10.1161%2F01.CIR.103.15.1936.</p><p>Zangerle A, Kiechl S, Spiegel M et al. Recanalization after thrombolysis in stroke patients: predictors and prognostic implications. Neurology. 2007;68(1):39–44. DOI: 10.1212%2F01.wnl.0000250341.38014.d2.</p><p>Vaidyula VR, Rao AK, Mozzoli M et al. Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand. Diabetes. 2006;55(1):202–8. DOI: 10.2337%2Fdiabetes.55.01.06.db05-1026.</p><p>Lemkes BA, Hermanides J, Devries JH et al. Hyperglycemia: a prothrombotic factor? J ThrombHaemost. 2010;8(8):1663–9. DOI: 10.1111/j.1538-7836.2010.03910.x. Epub 2010 May 12.</p><p>Pandolfi A, Giaccari A, Cilli C et al. Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat. Acta Diabetol. 2001;38(2):71–6. DOI: 10.1007%2Fs005920170016.</p><p>Парфенов ВА, Хасанова ДР. Ишемический инсульт. Москва: МИА; 2012. 288 с. [Parfenov VA, Khasanova DR. Ishemicheskiy insul't. Moskva: MIA; 2012. 288 p.]</p></div><br />

The authors declare that there are no conflicts of interest present.